Potential use of transrenal DNA for non-invasive monitoring and prognosis of colorectal cancer

Biomarkers ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 524-529
Author(s):  
Wei Chen ◽  
Yingying Liao ◽  
Chunxia Yang ◽  
Zhicheng Fang ◽  
Boyi Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Invasive Monitoring ◽  
Non Invasive ◽  
Potential Use

scholarly journals Parvimonas micra as a putative non-invasive faecal biomarker for colorectal cancer

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Thyra Löwenmark ◽  
Anna Löfgren-Burström ◽  
Carl Zingmark ◽  
Vincy Eklöf ◽  
Michael Dahlberg ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Population Based ◽  
Non Invasive ◽  
Test Sensitivity ◽  
Parvimonas Micra ◽  
Increased Risk ◽  
Microbial Biomarkers ◽  
Faecal Samples ◽  
Potential Use

Abstract The use of faecal microbial markers as non-invasive biomarkers for colorectal cancer (CRC) has been suggested, but not fully elucidated. Here, we have evaluated the importance of Parvimonas micra as a potential non-invasive faecal biomarker in CRC and its relation to other microbial biomarkers. The levels of P. micra, F. nucleatum and clbA + bacteria were quantified using qPCR in faecal samples from a population-based cohort of patients undergoing colonoscopy due to symptoms from the large bowel. The study included 38 CRC patients, 128 patients with dysplasia and 63 controls. The results were validated in a second consecutive CRC cohort including faecal samples from 238 CRC patients and 94 controls. We found significantly higher levels of P. micra in faecal samples from CRC patients compared to controls. A test for P. micra could detect CRC with a specificity of 87.3% and a sensitivity of 60.5%. In addition, we found that combining P. micra with other microbial markers, could further enhance test sensitivity. Our findings support the potential use of P. micra as a non-invasive biomarker for CRC. Together with other microbial faecal markers, P. micra may identify patients with “high risk” microbial patterns, indicating increased risk and incidence of cancer.

Is non-invasive monitoring for detection of heart transplant rejection and cardiac vasculopathy reliable?

2005 ◽  
Vol 53 (S 01) ◽  
Author(s):  
E Usta ◽  
C Burgstahler ◽  
S Schröder ◽  
A Küttner ◽  
A Kopp ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Transplant Rejection ◽  
Invasive Monitoring ◽  
Non Invasive ◽  
Heart Transplant Rejection

Fecal microRNAs as non-invasive biomarkers for the detection of colorectal cancer: a systematic review

2019 ◽  
Vol 31 (1) ◽  
Author(s):  
Antonio Francavilla ◽  
Sonia Tarallo ◽  
Barbara Pardini ◽  
Alessio Naccarati
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Non Invasive

Role of Cardiac MRI in Detecting Familial Hypertrophic Cardiomyopathy: Review

2016 ◽  
Vol 1 (1) ◽  
pp. 4
Author(s):  
Marymol Koshy ◽  
Bushra Johari ◽  
Mohd Farhan Hamdan ◽  
Mohammad Hanafiah
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Magnetic Resonance ◽  
Genetic Disorder ◽  
Familial Hypertrophic Cardiomyopathy ◽  
Non Invasive ◽  
Wide Range ◽  
Proper Diagnosis ◽  
Magnetic Resonance Imaging Mri ◽  
Potential Use

Hypertrophic cardiomyopathy (HCM) is a global disease affecting people of various ethnic origins and both genders. HCM is a genetic disorder with a wide range of symptoms, including the catastrophic presentation of sudden cardiac death. Proper diagnosis and treatment of this disorder can relieve symptoms and prolong life. Non-invasive imaging is essential in diagnosing HCM. We present a review to deliberate the potential use of cardiac magnetic resonance (CMR) imaging in HCM assessment and also identify the risk factors entailed with risk stratification of HCM based on Magnetic Resonance Imaging (MRI).

Sign in / Sign up

Export Citation Format

Share Document