In the current global scenario, in which mobility has been strongly impacted, it is relevant to highlight certain mobility experiences of Indigenous Latin American peoples, in which new cultural and geographical elements justify revisiting this phenomenon. In this context, the mobility of the Aymara ethnic group offers an opportunity for such a second look. Although the subject has been approached from the perspectives of internal migration processes and physical movement, as in other Latin American cases, studies have omitted some important aspects for its analysis, such as the practices, meanings, and political implications associated with mobility. Based on the new mobility paradigm, this article seeks to strengthen the perspective on mobility by researching rural-urban mobility practices and their meaning regarding the experiences of Aymara people who migrated from the rural municipality of Putre to settle in the city of Arica from the 1950s. At the same time, it is shown that these Aymara mobility practices imply spatiotemporal dynamics that are key for the construction of place, and allow for a widening of base elements that should be considered in the new mobility paradigm. This research is based on five years of ethnography, including mobile accompaniment and semi-structured interviews. This methodological approach has allowed researchers to explore how elements related to physical and symbolic mobility have constantly constructed relational spaces within the Arica and Parinacota region over time. This shows that mobility does not only refer to physical movement, but to politics, emotions, culture, and memory as well. From these results, the article examines and discusses key elements related to physical and symbolic mobility, and their implications in political and intercultural terms.