Oral delivery of solid lipid nanoparticles: underlining the physicochemical characteristics and physiological condition affecting the lipolysis rate

2021 ◽  
pp. 1-16
Author(s):  
Mohammad Mahmoudian ◽  
Solmaz Maleki Dizaj ◽  
Sara Salatin ◽  
Raimar Löbenberg ◽  
Maryam Saadat ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Delivery ◽  
Physiological Condition ◽  
Physicochemical Characteristics ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Solid lipid nanoparticles for oral delivery of curcumin

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
C Righeschi ◽  
M Bergonzi ◽  
B Isacchi ◽  
A Bilia
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Delivery ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Preparation, Characterization and Optimization of Irbesartan Loaded Solid Lipid Nanoparticles for Oral Delivery

2021 ◽  
pp. 97-104
Author(s):  
Kumara Swamy S ◽  
Ramesh Alli
Keyword(s):  
Drug Release ◽  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Oral Delivery ◽  
Entrapment Efficiency ◽  
Lipid Nanoparticles ◽  
Sustained Drug Release ◽  
Bioavailability Enhancement ◽  
Solid Lipid

The purpose of this study was to develop and evaluate irbesartan (IS) loaded solid lipid nanoparticles (SLNs; IS-SLNs) that might enhance the oral bioavailability of IS. IS, an angiotensin-receptor antagonist, used to treat hypertension. However, poor aqueous solubility and poor oral bioavailability has limited therapeutic applications of IS. Components of the SLNs include either of trimyristin/tripalmitin/tristearin/trilaurate/stearic acid/beeswax, and surfactants (Poloxamer 188 and soylecithin). The IS-SLNs were prepared by hot homogenization followed by ultrasonication method and evaluated for particle size, poly dispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE), drug content and in vitro drug release. The physical stability of optimized formulation was studied at refrigerated and room temperature for two months. The optimized IS-SLN formulation (F4) had a mean diameter of about 217.6±3.62 nm, PDI of 0.163±0.032, ZP of -28.5±4.12, assay of 99.8±0.51 and EE of 93.68±2.47%. The formulation showed sustained drug release compared with control formulation over 24 h. Optimized formulation was found to be stable over two months. IS-SLN showed nearly spherical in shape using and converted to amorphous form by DSC. Thus, the results conclusively demonstrated SLNs could be considered as an alternative delivery system for the oral bioavailability enhancement of IS.

Fermentation of bioactive solid lipid nanoparticles by human gut microflora

2016 ◽  
Vol 7 (1) ◽  
pp. 516-529 ◽  
Author(s):  
Ana Raquel Madureira ◽  
Débora Campos ◽  
Beatriz Gullon ◽  
Cláudia Marques ◽  
Luís M. Rodríguez-Alcalá ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Intestinal Epithelium ◽  
Solid Lipid Nanoparticles ◽  
Oral Delivery ◽  
Lipid Nanoparticles ◽  
Gut Microflora ◽  
Human Gut ◽  
Solid Lipid ◽  
Harsh Conditions

Solid lipid nanoparticles (SLNs) can be used for oral delivery of phenolic compounds in order to protect them from the harsh conditions of digestion and improve their bioavailability in the intestinal epithelium.

scholarly journals Preparation and Optimization of Triptolide-Loaded Solid Lipid Nanoparticles for Oral Delivery with Reduced Gastric Irritation

Molecules ◽  
2013 ◽  
Vol 18 (11) ◽  
pp. 13340-13356 ◽  
Author(s):  
Cong Zhang ◽  
Conghui Gu ◽  
Fan Peng ◽  
Wei Liu ◽  
Jiangling Wan ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Delivery ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Gastric Irritation

Characterization of solid lipid nanoparticles produced with carnauba wax for rosmarinic acid oral delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (29) ◽  
pp. 22665-22673 ◽  
Author(s):  
Ana Raquel Madureira ◽  
Débora A. Campos ◽  
Pedro Fonte ◽  
Sara Nunes ◽  
Flávio Reis ◽  
...  
Keyword(s):  
Solid State ◽  
Solid Lipid Nanoparticles ◽  
Rosmarinic Acid ◽  
Oral Delivery ◽  
Lipid Nanoparticles ◽  
Carnauba Wax ◽  
Solid Lipid

Illustration of the final product of solid carnauba nanoparticles loaded with rosmarinic acid in the dried solid state suitable for food incorporation.

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