Novel biomarkers for prediction of outcome and therapeutic response in juvenile idiopathic arthritis

2021 ◽  
Author(s):  
Silvia Rosina ◽  
Valentina Natoli ◽  
Stefania Santaniello ◽  
Chiara Trincianti ◽  
Alessandro Consolaro ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Therapeutic Response ◽  
Prediction Of Outcome ◽  
Novel Biomarkers

scholarly journals Evaluation of anti-TNF therapeutic response in patients with inflammatory bowel disease: Current and novel biomarkers

EBioMedicine ◽  
2021 ◽  
Vol 66 ◽  
pp. 103329
Author(s):  
Guanglin Cui ◽  
Qingbo Fan ◽  
Zhenfeng Li ◽  
Rasmus Goll ◽  
Jon Florholmen
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Therapeutic Response ◽  
Novel Biomarkers ◽  
Inflammatory Bowel

scholarly journals Salivary proteomics in monitoring the therapeutic response of canine oral melanoma

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256167
Author(s):  
Sekkarin Ploypetch ◽  
Sittiruk Roytrakul ◽  
Janthima Jaresitthikunchai ◽  
Narumon Phaonakrop ◽  
Patharakrit Teewasutrakul ◽  
...  
Keyword(s):  
Therapeutic Response ◽  
Cost Effective ◽  
Term Survival ◽  
Non Invasive ◽  
Oral Melanoma ◽  
Liquid Chromatography Tandem Mass ◽  
Novel Biomarkers ◽  
Saliva Collection ◽  
Short Term Survival

Saliva biomarkers are suitable for monitoring the therapeutic response of canine oral melanoma (COM), because saliva directly contacts the tumor, and saliva collection is non-invasive, convenient and cost effective. The present study aimed to investigate novel biomarkers from the salivary proteome of COM treated with surgery and a chemotherapy drug, carboplatin, 1–6 times, using a liquid chromatography–tandem mass spectrometry approach. The expression of a potential salivary biomarker, ubiquitin D (UBD), was observed and verified by western blot analysis. A significantly increased ratio of free UBD (fUBD) to conjugated UBD (cUBD) was shown in the pre-surgery stage (PreS) in OM dogs with short-term survival (STS) (less than 12 months after surgery) compared with that with long-term survival (more than 12 months after surgery). In dogs with STS, the ratio was also shown to be augmented in PreS compared with that after surgery, followed by treatment with carboplatin twice, 4 and 5 times [After treatment (AT)2, AT4 and AT5]. In addition, the expression of fUBD was enhanced in PreS compared with that of AT2 in the STS group. In conclusion, this study revealed that a ratio of fUBD to cUBD in PreS was plausibly shown to be a potential prognostic biomarker for survival in dogs with OM.

scholarly journals Assessment of EN-RAGE, sRAGE and EN-RAGE/sRAGE as potential biomarkers in patients with autoimmune hepatitis

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Rui Wu ◽  
Yan Liu ◽  
Ruyu Yan ◽  
Xiaoyu Liu ◽  
Liang Duan
Keyword(s):  
Autoimmune Hepatitis ◽  
Therapeutic Response ◽  
Healthy Controls ◽  
Predictive Values ◽  
Diagnosis And Prognosis ◽  
Natural Behaviour ◽  
Gender And Age ◽  
Novel Biomarkers ◽  
Inflammatory Immune Response ◽  
Normal Alt

Abstract Background Autoimmune hepatitis (AIH) is a liver disease characterized by the autoimmune-induced injury of hepatocytes which can lead to cirrhosis and hepatic failure. The diagnosis and disease management of AIH patients remain challenging due to the diversity of clinical phenotypes and the presence of confounders such as alcohol and viruses. Recently, EN-RAGE and sRAGEs have been implicated in inflammatory-immune response. Nonetheless, their natural behaviour and relationship to disease activity as well as clinical predictive values in AIH development or therapy-induced remission have not been reported. Methods Sixty-seven AIH patients and thirty gender- and age-matched healthy controls (HC) were enrolled. The serum concentrations of EN-RAGE, sRAGE and their ratio (EN-RAGE/sRAGE) in these subjects were measured by ELISA. Besides, the correlations of three parameters with clinical features and therapeutic response were analyzed, respectively. Furthermore, their potential predictive values for monitoring the AIH progression and therapeutic response were also evaluated. Results Higher serum EN-RAGE, lower sRAGE and higher EN-RAGE/sRAGE value were observed in AIH patients. EN-RAGE and sRAGE as well as EN-RAGE/sRAGE were correlated with liver necroinflammation parameters, cirrhosis occurrence and therapeutic response. In addition, we identified that EN-RAGE/sRAGE, EN-RAGE and sRAGE had valuable predicting power for AIH patients, AIH patients with normal ALT and cirrhosis incidence, respectively. More importantly, EN-RAGE/sRAGE also exerted predicting power for the remission in AIH patients. Conclusions AIH patients rendered distinct patterns of serum EN-RAGE, sRAGE or EN-RAGE/sRAGE compared to healthy controls. Moreover, these three parameters exhibited potentials as novel biomarkers for AIH diagnosis and prognosis evaluation.

Imaging in juvenile idiopathic arthritis (JIA): an update with particular emphasis on MRI

2013 ◽  
Vol 54 (9) ◽  
pp. 1015-1023 ◽  
Author(s):  
Maria Beatrice Damasio ◽  
L Tantum de Horatio ◽  
P Boavida ◽  
K Lambot-Juhan ◽  
K Rosendahl ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Disease Activity ◽  
Structural Damage ◽  
Therapeutic Response ◽  
Unknown Origin ◽  
Therapeutic Agents ◽  
Chronic Arthritis ◽  
Present Knowledge ◽  
Radiographic Assessment ◽  
Future Challenges

Juvenile idiopathic arthritis (JIA) is a heterogeneous condition encompassing all forms of chronic arthritis of unknown origin and with onset before 16 years of age. During the last decade new, potent therapeutic agents have become available, underscoring the need for accurate monitoring of therapeutic response on both disease activity and structural damage to the joint. However, so far, treatment efficacy is based on clinical ground only, although clinical parameters are poor markers for disease activity and progression of structural damage. Not so for rheumatoid arthritis patients where the inclusion of radiographic assessment has been required by FDA to test the disease-modifying potential of new anti-rheumatic drugs. In imaging of children with JIA there has been a shift from traditional radiography towards newer techniques such as ultrasound and MRI, however without proper evaluation of their accuracy and validity. We here summarize present knowledge and discuss future challenges in imaging children with JIA.

FRI0504 TNF-Alpha Gene Polymorphisms and Juvenile Idiopathic Arthritis: Influence on Disease Outcome and Therapeutic Response

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 611.2-612
Author(s):  
A. Scardapane ◽  
R. Ferrante ◽  
M. Nozzi ◽  
V. Marzetti ◽  
M. Lucantoni ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Gene Polymorphisms ◽  
Therapeutic Response ◽  
Disease Outcome ◽  
Tnf Alpha ◽  
Alpha Gene

scholarly journals Novel biomarkers for early targeted and individualized treatment in Juvenile Idiopathic Arthritis

2020 ◽  
Vol 31 (2) ◽  
pp. 230
Author(s):  
Artemis Koutsonikoli ◽  
Anna Taparkou ◽  
Polyxeni Pratsidou-Gkertsi ◽  
Vassiliki Sgouropoulou ◽  
Theodoros Dimitroulas ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Individualized Treatment ◽  
Novel Biomarkers
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