The current status and future directions of hepatitis B antiviral drug discovery

Most aspects of glycobiology play important roles in the ‘life’ of viruses, for example in the correct folding of their envelope glycoproteins as well as in immune representation and escape. The pathogenicity of three major human pathogens, HCV (hepatitis C virus), HBV (hepatitis B virus) and HIV, which collectively infect more than 560 million people worldwide, is dependent on their glycoproteins. As the sugars (or glycans) that the viruses rely on are supplied by the host cell, we can exploit our knowledge of glycobiology to target this apparent Achilles' heel of these viruses.

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Current status, problems, and future directions of bioinformatics for drug discovery

Folia Pharmacologica Japonica ◽

10.1254/fpj.129.51 ◽

2007 ◽

Vol 129 (1) ◽

pp. 51-55

Author(s):

Hiroki Shirai ◽

Masato Kobori

Keyword(s):

Drug Discovery ◽

Current Status ◽

Future Directions

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Current status and future directions of high-throughput ADME screening in drug discovery

Journal of Pharmaceutical Analysis ◽

10.1016/j.jpha.2020.05.004 ◽

2020 ◽

Vol 10 (3) ◽

pp. 201-208 ◽

Cited By ~ 2

Author(s):

Wilson Z. Shou

Keyword(s):

Drug Discovery ◽

High Throughput ◽

Current Status ◽

Future Directions

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Lignans and Their Derivatives from Plants as Antivirals

Molecules ◽

10.3390/molecules25010183 ◽

2020 ◽

Vol 25 (1) ◽

pp. 183 ◽

Cited By ~ 10

Author(s):

Qinghua Cui ◽

Ruikun Du ◽

Miaomiao Liu ◽

Lijun Rong

Keyword(s):

Natural Products ◽

Chronic Hepatitis ◽

Drug Discovery ◽

Hepatitis B ◽

Antiviral Drug ◽

Structural Similarity ◽

Pharmacological Properties ◽

Structural Classification ◽

Antiviral Activities ◽

Venereal Warts

Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans—podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals—are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed.

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