Lignans and Their Derivatives from Plants as Antivirals

Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans—podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals—are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed.

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Antiviral drug discovery: broad-spectrum drugs from nature

Natural Product Reports ◽

10.1039/c4np00085d ◽

2015 ◽

Vol 32 (1) ◽

pp. 29-48 ◽

Cited By ~ 77

Author(s):

J. P. Martinez ◽

F. Sasse ◽

M. Brönstrup ◽

J. Diez ◽

A. Meyerhans

Keyword(s):

Natural Products ◽

Drug Discovery ◽

Broad Spectrum ◽

Viral Infections ◽

Antiviral Drug ◽

Marine Organisms ◽

Antiviral Activities

Exploiting the power of nature to fight viral infections. This review describes the concept of direct- and host-acting natural products with broad-spectrum antiviral activities and provides promising examples derived from plants, fungi, bacteria and marine organisms.

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Antiviral Natural Products for Arbovirus Infections

Molecules ◽

10.3390/molecules25122796 ◽

2020 ◽

Vol 25 (12) ◽

pp. 2796 ◽

Cited By ~ 4

Author(s):

Vanessa Shi Li Goh ◽

Chee-Keng Mok ◽

Justin Jang Hann Chu

Keyword(s):

Natural Products ◽

Side Effects ◽

Plant Extracts ◽

Antiviral Drug ◽

Good Tolerability ◽

Antiviral Compounds ◽

Potential Source ◽

Herbal Plants ◽

Antiviral Activities ◽

Arboviral Diseases

Over the course of the last 50 years, the emergence of several arboviruses have resulted in countless outbreaks globally. With a high proportion of infections occurring in tropical and subtropical regions where arthropods tend to be abundant, Asia in particular is a region that is heavily affected by arboviral diseases caused by dengue, Japanese encephalitis, West Nile, Zika, and chikungunya viruses. Major gaps in protection against the most significant emerging arboviruses remains as there are currently no antivirals available, and vaccines are only available for some. A potential source of antiviral compounds could be discovered in natural products—such as vegetables, fruits, flowers, herbal plants, marine organisms and microorganisms—from which various compounds have been documented to exhibit antiviral activities and are expected to have good tolerability and minimal side effects. Polyphenols and plant extracts have been extensively studied for their antiviral properties against arboviruses and have demonstrated promising results. With an abundance of natural products to screen for new antiviral compounds, it is highly optimistic that natural products will continue to play an important role in contributing to antiviral drug development and in reducing the global infection burden of arboviruses.

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Drug discovery and development of antiviral agents for the treatment of chronic hepatitis B virus infection

Antiviral Agents ◽

10.1007/978-3-0348-7784-8_4 ◽

2001 ◽

pp. 111-183 ◽

Cited By ~ 4

Author(s):

Kirk A. Staschke ◽

Joseph M. Colacino

Keyword(s):

Chronic Hepatitis ◽

Drug Discovery ◽

Hepatitis B Virus ◽

Virus Infection ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Antiviral Agents ◽

Hepatitis B Virus Infection ◽

Chronic Hepatitis B Virus ◽

B Virus

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Ostenomalacia Caused by Antiviral Drug for Chronic Hepatitis B: A Case Report

Orthopedics & Traumatology ◽

10.5035/nishiseisai.60.148 ◽

2011 ◽

Vol 60 (1) ◽

pp. 148-151 ◽

Cited By ~ 3

Author(s):

Yuji Kishimoto ◽

Toru Okano ◽

Ryota Teshima

Keyword(s):

Chronic Hepatitis ◽

Case Report ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Antiviral Drug

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COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B

Diagnostics ◽

10.3390/diagnostics10070491 ◽

2020 ◽

Vol 10 (7) ◽

pp. 491

Author(s):

Thuy Thi Bich Phung ◽

Son Van Chu ◽

Son Thien Vu ◽

Hanh Thi Pham ◽

Hang Minh Nguyen ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Single Point ◽

Antiviral Drug ◽

Multiple Point ◽

Resistance Mutations ◽

Hbv Genotypes ◽

Treatment Naïve ◽

Pcr Method

We investigated Nucleos(t)ide-analogue (NA)-resistance mutations (mt) in 142 treatment-naive children with Chronic Hepatitis B (CHB), using a sensitive co-amplification at lower denaturation temperature (COLD)-PCR with Sanger DNA sequencing. An NA resistance-associated mt in the hepatitis B virus (HBV) reverse transcriptase (RT) was found in 66.2% of the patients, with nonclassical mt contributing the most (64.8%). Significantly higher frequencies of Lamivudine (LMV) and Adefovir dipivoxil (ADF) resistance-associated mt were found in genotypes B and C, respectively (ORLMV/ADF: 1495.000; 95% CI: 89.800–24,889.032; p < 0.001). Single-point mt associated to LMV and ADF resistance were detected in 59.9% of the tested children with rtV207M (38.0%) and rtN238T (9.9%) being the most frequent. Multiple-point mt were found only in 8 cases (5.6%): 6 children carried double mt (rtV207M + rtL229V; rtV207M + rtI233V; rtV207I + rtV207M × 2 cases; rtV207M + rtS213T; rtN238A + rtS256G) relating to LMV or/and ADF resistance and 3 children carried triple mt (rtL180M + rtM204I + rtN238T; rtV207M + rtS213T + rtS256G) or quadruple mt (rtL180M + rtM204V + rtV207I/M) for LMV-ADF resistance and Entecavir-reduced susceptibility. Our data indicate that significantly higher frequencies of LMV and ADF-associated mutations were found in treatment-naïve children infected with HBV genotypes B and C, respectively. The developed COLD-PCR method and obtained data may contribute to the development of suitable treatments for children with CHB.

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