The combined effects of noise and vibration stress on sex hormone levels, fertility capacity, and the protective role of cinnamon extract in rats: an experimental study

2022 ◽  
pp. 1-10
Author(s):  
Hamideh Pirami ◽  
Ali Khavanin ◽  
Farshad Nadri ◽  
Ali Tajpoor ◽  
Younes Mehrifar ◽  
...  
Keyword(s):  
Experimental Study ◽  
Protective Role ◽  
Sex Hormone ◽  
Combined Effects ◽  
Noise And Vibration ◽  
Hormone Levels ◽  
Cinnamon Extract ◽  
Vibration Stress

scholarly journals Assessment of the toxicity effects of nicotine on sperm and IVF and the potential protective role of silymarin—an experimental study in mice

2020 ◽  
Vol 25 (1) ◽  
Author(s):  
Mohammad Rahimi-Madiseh ◽  
Mohsen Mohammadi ◽  
Amin Hassanvand ◽  
Reza Ahmadi ◽  
Maasume Shahmohammadi ◽  
...  
Keyword(s):  
Experimental Study ◽  
Protective Role ◽  
Toxicity Effects

Individual and combined effects of Fusarium toxins on apoptosis in PK15 cells and the protective role of N -acetylcysteine

2018 ◽  
Vol 111 ◽  
pp. 27-43 ◽  
Author(s):  
Wei Zhang ◽  
Shihua Zhang ◽  
Meiling Zhang ◽  
Lige Yang ◽  
Baojing Cheng ◽  
...  
Keyword(s):  
Protective Role ◽  
Combined Effects ◽  
Fusarium Toxins

scholarly journals Role of Flutamide on Testosterone Induced Prostatic Hyperplasia in Long Evans Rats

1970 ◽  
Vol 8 (1) ◽  
pp. 16-20
Author(s):  
Md Atiar Rahman ◽  
Humaira Naushaba ◽  
Jesmin Akter ◽  
Uttam Kumar Paul ◽  
Nahid Ahmed Khan
Keyword(s):  
Treated Group ◽  
Protective Role ◽  
Prostatic Hyperplasia ◽  
Sex Hormone ◽  
Control Group ◽  
Medical College ◽  
Male Sex ◽  
Long Evans ◽  
Group B

Context: Testosterone is the male sex hormone responsible for growth of secondary sexual character and accessory sex organs. Despite the effectiveness as a male sex hormone, testosterone causes Benign Prostatic Hyperplasia (BPH) resulting in urinary dysfunction. On the other hand, flutamide is a pure antitestosterone, which blocks the effects of Dihydro testosterone (DHT) at the testosterone receptor and prevents BPH. Therefore the present study was designed to observe the protective role of flutamide on testosterone induced prostatic hyperplasia. Objective: To observe the effects of flutamide on testosterone induced prostatic hyperplasia in Long Evans rats. Study design: An experimental study. Place and period of study: The study was carried out in the Department of Anatomy, Sir Salimullah Medical College, Dhaka during the period of July 2006 to June 2007. Materials & Methods: Forty five matured male long Evans rats of age 8-10 weeks and weighing 200-300 gms were used in this study. They were divided into three equal groups. Group A was vehicle (olive oil) control group, Group B was testosterone treated group and Group C was testosterone & flutamide treated group. Comparative study in different groups were done microscopically. Results: There was significant reduction (P<0.001) in prostatic hyperplasia. The mean percentage volume of stroma in flutamide treated rats was lower than the testosterone treated rats. Conclusion: It can be concluded from this study that flutamide is an effective drug against testosterone induced prostatic hyperplasia. Key words: Prostate; Testosterone; Flutamide. DOI: 10.3329/bja.v8i1.6104 Bangladesh Journal of Anatomy January 2010, Vol. 8 No. 1 pp. 16-20

Methyl Gallate Mitigates Doxorubicin-Induced Peripheral Cytopenias: A Preclinical Experimental Study

2021 ◽  
pp. 4529-4534
Author(s):  
Akheruz Z. Ahmed ◽  
Prakashchandra Shetty ◽  
Shakta M. Satyam ◽  
Melanie Rose D’Souza ◽  
Archana M Herle ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Experimental Study ◽  
Single Dose ◽  
Wistar Rats ◽  
Protective Role ◽  
Methyl Gallate ◽  
Life Threatening ◽  
Complete Blood Counts ◽  
Different Doses

Myelosuppression by doxorubicin is a life-threatening adverse effect in cancer patients undergoing chemotherapy. Methyl gallate is an antioxidant found in a variety of plant species. The study aimed to demonstrate the protective role of methyl gallate on doxorubicin-induced cytopenias in Wistar rats. The animals were prophylactically treated with two different doses of methyl gallate (150mg/kg/day and 300mg/kg/day) orally for seven days. Doxorubicin (25mg/kg; single dose) was administered through intraperitoneal route on the seventh day to induce cytopenias. Blood was collected 24 hours after the administration of doxorubicin and complete blood counts were estimated. There was significant (p≤0.05) development of peripheral cytopenias in doxorubicin treated control rats compared to normal saline treated control rats. Methyl gallate at both the doses significantly (p≤0.05) mitigated doxorubicin induced cytopenias compared to doxorubicin treated control rats. The findings of the present study revealed that methyl gallate has protective role in doxorubicin-induced cytopenias in Wistar rats. Following clinical studies, methyl gallate may serve as a viable alternative to growth factors in patients undergoing chemotherapy.

scholarly journals The effects of myricitrin and vitamin E against reproductive changes induced by D-galactose as an aging model in female mice: An experimental study

2019 ◽  
Author(s):  
Mina Omidi ◽  
Akram Ahangarpour ◽  
Seyed Ali Mard ◽  
Layasadat Khorsandi
Keyword(s):  
Experimental Study ◽  
Vitamin E ◽  
Ovarian Tissue ◽  
Colorimetric Method ◽  
Sex Hormone ◽  
Enzyme Linked Immunosorbent Assay ◽  
General Function ◽  
Key Words Aging ◽  
Hormone Levels ◽  
Total Antioxidant

Background: Aging is accompanied by decreasing general function in the cells and tissues. D-galactose (D-gal) induces aging and plays a role in the pathogenesis of it. Myricitrin is a plant-derived antioxidant. Objective: The present study was performed to evaluate the effects of myricitrin on antioxidant defense, sex hormone levels, uterus, and ovarian histology in D-galinduced aging female mouse model. Materials and Methods: In this experimental study, 72 female adult NMRI mice, weighing 30-35 gr, 3-4 months old, were randomly divided into six groups (n = 12/each): (I) Control (vehicle; normal saline), (II) D-gal at 500 mg/kg/d for 45 days, (III-V) D-gal + myricitrin-treated groups (these groups received myricitrin at 5, 10, and 20 mg/kg/d, and (VI) D-gal + 100 mg/kg/d vitamin E orally for the last 28 days. The antioxidant indices were done on the basis of colorimetric method, and sex hormone levels were measured by using enzyme-linked immunosorbent assay kits. Histological assessment of the uterus and ovaries were also evaluated. Results: D-gal impaired the estrous cycle, also degenerative changes occur in the ovarian follicles and damage to the uterus and ovarian tissue occurrs. In D-gal group, the level of sex hormones (p = 0.03) and the total antioxidant capacity (p = 0.002) decreased, while the level of malondialdehyde and gonadotropins increased (p = 0.03). Myricitrin at lower doses and vitamin E ameliorated the D-gal effects. Conclusion: These findings suggest that myricitrin can effectively prevent D-galinduced oxidation and aging in mice. The effect of myricitrin was equivalent and sometimes better than vitamin E. Key words: Aging, D-galactose, Mice, Myricitrin, Vitamin E.

Changes in anti mullerian hormone levels and follicle counts after tubal sterilization and the possible protective role of curcumin in a female rat model

2013 ◽  
Vol 100 (3) ◽  
pp. S314
Author(s):  
G. Destici Isgoren ◽  
O.L. Tapisiz ◽  
B. Dilbaz ◽  
S. Kiykac Altinbas ◽  
G. Simsek ◽  
...  
Keyword(s):  
Rat Model ◽  
Protective Role ◽  
Female Rat ◽  
Tubal Sterilization ◽  
Hormone Levels

scholarly journals Role of Sex Hormone Levels and Psychological Stress in the Pathogenesis of Autoimmune Diseases

Cureus ◽  
2017 ◽  
Author(s):  
Salman Assad ◽  
Hamza H Khan ◽  
Haider Ghazanfar ◽  
Zarak H Khan ◽  
Salman Mansoor ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Psychological Stress ◽  
Sex Hormone ◽  
Hormone Levels

scholarly journals Evidence against protective role of sex hormone estrogen in cisplatin-induced nephrotoxicity in ovarectomized rat model

2013 ◽  
Vol 20 (1) ◽  
pp. 43 ◽  
Author(s):  
Mehdi Nematbakhsh ◽  
Hamid Nasri ◽  
Ardeshir Talebi ◽  
Ali-Asghar Pilehvarian ◽  
Tahereh Safari ◽  
...  
Keyword(s):  
Rat Model ◽  
Protective Role ◽  
Sex Hormone
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