scholarly journals Antimicrobials associated adverse drug reaction profiling: a four years retrospective study (Pharmacovigilance study)

2021 ◽  
Vol 57 (1) ◽  
pp. 177-187
Author(s):  
Manju Agrawal ◽  
Preeti Singh ◽  
Usha Joshi
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Retrospective Study

scholarly journals Cutaneous adverse drug reaction in Human Immunodeficiency virus patient associated with antiviral therapy: A retrospective study

2019 ◽  
Author(s):  
Vidyani Adiningtyas ◽  
Cita Rosita Sigit Prakoeswa ◽  
Erwin Astha Triyono
Keyword(s):  
Human Immunodeficiency Virus ◽  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Retrospective Study ◽  
Antiviral Therapy ◽  
General Hospital ◽  
Maculopapular Rash ◽  
Clinical Feature ◽  
Hiv Patients ◽  
Immunodeficiency Virus

Drug hypersensitivity reactions specifically cutaenous adverse drug reaction (CADR) occur at higher rate in human immunodeficiency virus (HIV)- positive patients than general population and cause significant morbidity, in early era of antiretroviral therapy (ART), the incidence of skin rashes can reach 50% in HIV patients taking HIV medications. The purpose of this study is to evaluate the pattern of CADR in HIV patients associated with ART. A retrospective study took data from medical record CADR in HIV patients associated with ART at HIV ward, Dr. Soetomo General Hospital Surabaya, since January 2013 until December 2015. During the period of three years, there were 20 CADR patients in at HIV ward, Dr. Soetomo General Hospital Surabaya. The most common patient was male, with the highest age group of 25-44 years old, and the most clinical feature found were maculopapular rash, and Steven Johnson Syndrome (SJS). The most common antiviral therapy were nevirapine. The number of CADR in HIV patient associated with ART cases increased. The most clinical feature were maculopapular rash followed by SJS, only few cases of toxic epidermal necrolysis.

Repeat Adverse Drug Reaction-Related Hospital Admissions in Elderly Australians: A Retrospective Study at the Royal Hobart Hospital

Drugs & Aging ◽  
2017 ◽  
Vol 34 (10) ◽  
pp. 777-783 ◽  
Author(s):  
Nibu Parameswaran Nair ◽  
Leanne Chalmers ◽  
Bonnie J. Bereznicki ◽  
Colin M. Curtain ◽  
Luke R. Bereznicki
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Retrospective Study ◽  
Hospital Admissions

scholarly journals Clinical Interventions of Critical Care Pharmacist in the Therapeutic Management of Critically Ill Patients: a Retrospective Study in Bangladesh

2019 ◽  
Vol 18 (1) ◽  
pp. 113-119
Author(s):  
Md Jahidul Hasan ◽  
Raihan Rabbani ◽  
Sitesh C Bachar
Keyword(s):  
Adverse Drug Reaction ◽  
Critical Care ◽  
Drug Reaction ◽  
Drug Interaction ◽  
Retrospective Study ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Medication Management ◽  
Drug Management ◽  
Effective Medication

Critically ill patients at ICU are treated with poly pharmacy and conservative drug management is necessary for ensuring drugs’ safety and accuracy. The objective of this study was to analyze the qualitative intervention of critical care pharmacists (CCP) in critically ill patients’ effective medication management. This was a 6 months long observational study. All the provided suggestions of CCP were categorized into- A (drug-drug interaction), B (addition of new drug therapies), C (rational dosing of antibiotics), D (acceleration or deceleration of the doses) and E (adverse drug reaction). Out of total CCP’s 650 suggestions, 566 (87.08%) suggestions were accepted by doctors and modified the therapies, accordingly. CCP being a part of ICU’s multi professional team contribute the professional roles in generating safe, appropriate and quality prescriptions, which finally turns into quality pharmacotherapy for critically ill patients at ICU. Dhaka Univ. J. Pharm. Sci. 18(1): 113-119, 2019 (June)

Difficulties in the detection of the culprit drug for an adverse drug reaction in a complicated case

2008 ◽  
Vol 149 (19) ◽  
pp. 883-887 ◽  
Author(s):  
Henriette Kopcsányi ◽  
Julianna Feldmann ◽  
Zsófia Péch ◽  
Ágnes Jurcsik
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Complicated Case ◽  
Erythema Exsudativum Multiforme ◽  
Culprit Drug

Az adverz gyógyszerreakciók különféle klinikai megjelenési formái alapján a kiváltó gyógyszerre nehéz következtetni. A gyanúba vett gyógyszerek elhagyása után fellépő javulás vagy az empirikus tapasztalat, esetleg irodalmi adatok alapján lehet a felelős gyógyszert feltételezni. A gyógyszerérzékenység bizonyítása bonyolult, jól átgondolt orvosi tevékenység útján lehetséges, és azokban az esetekben szükséges, amikor a gyanús gyógyszer más vegyületcsoportba tartozó szerrel nem helyettesíthető, és a betegnek feltétlenül szükséges szednie. A jelen közlemény célja egy eset kapcsán körvonalazni azokat a lehetőségeket és veszélyeket, melyek a kivizsgálás során alkalmazhatók, illetve megjelenhetnek. A kivizsgálás során használt módszerek a gyanúba vett gyógyszerekkel – lamotrigin, risperidon, sertralin – zopiclonum, atorvastatin elvégzett epicutan teszt során egyedül a sertralin adott a multiform tünetekkel azonos pozitív reakciót. A pozitív bőrteszt területéről készült hisztológiai vizsgálat eredménye visszautalt az eredetileg észlelt klinikai formára (erythema exsudativum multiforme Stevens–Johnson-szindróma). A beteg bipoláris affektív zavara miatt a negatív bőrtesztet adó készítményekkel per os provokáció történt, ez azonban a beteg számára kockázatos, de az egyetlen megbízható és biztos módszer. Az elvégzett per os expozíció során a törzsön a lamotrigintől már tört adag bevételét követően három órán belül diffúz erythema, 12 órán belül az alkalmazott szteroid- és antihisztamin-kezelés ellenére scarlatiniform exanthema jelent meg. Az eset érdekessége, hogy a gyanúba vett gyógyszerek során epicutan teszttel egy gyógyszer érzékenysége igazolódott, azonban a másik gyanúba vett készítménnyel végzett pozitív per os expozíciós próba is váratlanul tünetet provokált (scarlatiniform, azonnali reakciót). Megállapítható, hogy csupán egy bizonyos módszer még a klinikai képpel való egyező eredmény alapján sem elegendő adverz gyógyszerreakció provokáló tényezőjének bizonyítására.

1544-P: High Risk of Adverse Drug Reaction (ADR) in Older Adults with Type 1 Diabetes (T1D)

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1544-P ◽  
Author(s):  
ELENA TOSCHI ◽  
CHRISTINE SLYNE ◽  
ASTRID ATAKOV-CASTILLO ◽  
KAYLA SIFRE ◽  
ALYSSA B. DUFOUR ◽  
...  
Keyword(s):  
Older Adults ◽  
Adverse Drug Reaction ◽  
Type 1 Diabetes ◽  
Drug Reaction ◽  
High Risk

scholarly journals Legislation and current developments in adverse drug reaction reporting in Mongolia: how far are we?

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Zuzaan Zulzaga ◽  
Erdenetuya Myagmarsuren ◽  
Herman J. Woerdenbag ◽  
Eugene P. van Puijenbroek
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Drug Safety ◽  
Reporting System ◽  
Adverse Drug Reaction Reporting ◽  
Safety Data ◽  
Regulatory System ◽  
Basic Structure ◽  
Reaction Reporting ◽  
Adr Reporting

AbstractMonitoring adverse drug reactions is a vital issue to ensure drug safety and to protect the general public from medication-related harmful effects. In order to properly monitor drug safety, a regulatory system needs to be in place as well as an infrastructure that allows for analyzing national and international safety data. In Mongolia, adverse drug reaction (ADR) reporting activities have been implemented in the past decade. During this period, the basic structure and legal basis of an adverse drug reaction monitoring system was established. Because of the fragmented but growing healthcare system and the complexity of pharmaceutical issues in Mongolia, a sustainable process for the development of the adverse drug reaction reporting system is a key issue. The aim of this article is to disclose the Mongolian situation for the rest of the world and to share experiences on how an ADR reporting system can be developed towards a higher and more advanced level to contribute to both national and international drug safety issues. In this article, we review the features of the Mongolian health care and pharmaceutical systems, as well as the current development of the adverse drug reaction reporting system.

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