scholarly journals The Transport of Salt and Water across Isolated Rat Ileum

1967 ◽  
Vol 50 (3) ◽  
pp. 695-727 ◽  
Author(s):  
T. W. Clarkson

The flows of sodium, potassium, and chloride under electrical and chemical gradients and of salt and water in the presence of osmotic pressure gradients are described by phenomenological equations based on the thermodynamics of irreversible processes. The aim was to give the simplest possible description, that is to postulate the least number of active transport processes and the least number of separate pathways across the intestine. On this basis, the results were consistent with the following picture of the intestine: Two channels exist across this tissue, one allowing only passive transport of ions and the other only active. In the passive channel, the predominant resistance to ion flow is friction with the water in the channel. The electroosmotic flow indicates that the passive channel is lined with negative fixed charged groups having a surface charge density of 3000 esu cm-2. The values of the ion-water frictional coefficients, and the relationship between ionic concentrations and flows indicate that the passive channel is extracellular. The active channel behaves as two membranes in series, the first membrane being semipermeable but allowing active transport of sodium, and the second membrane being similar to the passive channel. Friction with the ions in the second "membrane" is the predominant resistance to water flow.

Biological membranes, lipid membranes and organic polymer membranes have some chemical similarities. All can transport water and it is likely that the molecular transport processes have some common features in the three types of system. Polymer membranes, being stable and strong, can be subjected to more varied and intensive study than can either lipid or biological membranes. Furthermore, the structures, dimensions and molecular organization of polymer membranes, which are very simple compared with their biological counterparts, can be characterized in some detail. It is already a reasonable objective to analyse transport phenomena in polymer membranes in terms of the molecular processes likely to occur in media of known structure. If the level of understanding in this area could be improved it might become possible to make some confident deductions about structure in lipid and biological membranes from observations on their transport properties. This review is intended to assess the current situation regarding the interpretation of flux data in structural terms and, perhaps, to encourage further developments. Although observations on transport processes are made by observing changes in the bulk phases in contact with the membrane, it is the processes within the membrane that are under study. The mathematical formulation of membrane transport must be designed to emphasize the role of the membrane as a phase in which irreversible processes are occurring. This requires the determination of diffusion coefficients, concentrations, activity coefficients and their profiles within the membrane. The concentration and activity of water in a membrane are studied through equilibrium absorption isotherms. These vary widely in form with the chemical structure and organization in polymer membranes. Almost nothing detailed is known about sorption by lipid membranes. Most flow processes are studied between pairs of aqueous solutions that contain solutes which may also be able to permeate the membrane. The possibility of several irreversible processes occurring simultaneously in the membrane can best be handled through the formalism of non-equilibrium thermodynamics. This formulation provides also a convenient method of introducing pressure and osmotic pressure as driving forces in addition to that of simple Fickian diffusion flow. A bridge between the phenomenological coefficients of thermodynamics and molecular processes can be built only on a model system. By regarding the membrane as intrinsically homogeneous and isotropic the frictional model can be applied in which steady flow is represented by a balance between thermodynamic driving forces and frictional retarding forces among the various flowing components and the membrane. A case of particular interest arises where the solute is an isotopically labelled species of water. The number of independent frictional coefficients in the two-component system is reduced from three to two. They can be determined from measurements of the tracer diffusion coefficient and the hydrodynamic or osmotic permeability of the membrane. This has been done for two sets of polymer membranes: highly hydrated hydrogels and moderately hydrated cellulose acetates. The membranes were prepared so as to be as nearly homogeneous as possible and it was found that the frictional coefficients observed were consistent with the homogeneous model theory. By applying a form of argument which has several times been used to diagnose the existence of pores in biological and lipid membranes, it was possible to deduce from the data on the synthetic membranes that they too transport water in, sometimes quite large, pores. This conclusion would be at variance with their known structures and shows that the argument is unsound when it is used as a criterion for the presence or absence of pores. It is clear also that the argument is valid only when applied to a homogeneous system and so would not be valid if applied to a system that were truly porous but also transported water through the matrix material supporting the pores.


2021 ◽  
pp. 1-27
Author(s):  
Junichi Hongu ◽  
Ryohei Horita ◽  
Takao Koide

Abstract This study proposes a modification of the Matsumoto equation using a directional parameter of tooth surfaces to adapt various gear finishing processes. The directional parameters of a contact surface, which affect oil film formations, have been discussed in the field of tribology; but this effect has been undetermined on the meshing gear tooth surfaces having directional machining marks. Thus, this paper investigates the relationship between the gear frictional coefficients and the directional parameters (based on ISO25178) of their tooth surfaces with the various finishing processes; and modifies the Matsumoto equation by introducing a new directional parameter to augment the various gear finishing processes. Our findings indicate that through optimizing the coefficient of the correction term the include the new directional parameter, the calculated friction values using the modified Matsumoto equation correlate more highly to the experimental friction values than that using the unmodified Matsumoto equation.


Author(s):  
Kelley C. Stewart ◽  
Rahul Kumar ◽  
John J. Charonko ◽  
Pavlos P. Vlachos ◽  
William C. Little

Left ventricular diastolic dysfunction (LVDD) and diastolic heart failure are conditions that affect the filling dynamics of the heart and affect 36% of patients diagnosed with congestive heart failure [1]. Although this condition is very prevalent, it currently remains difficult to diagnose due to inherent atrio-ventricular compensatory mechanisms including increased heart rate, increased left ventricular (LV) contractility, and increased left atrial pressure (LA). A greater comprehension of the governing flow physics in the left ventricle throughout the introduction of the heart’s compensatory mechanisms has great potential to substantially increase the understanding of the progression of diastolic dysfunction and in turn advance the diagnostic techniques.


2021 ◽  
Author(s):  
Matthew Johnson ◽  
Natasha Dowey ◽  
Rebecca Williams ◽  
Pete Rowley

<p>Pyroclastic density currents (PDCs) are hot, density-driven flows of gas, rock and ash generated during explosive volcanic eruptions, or from the collapse of lava domes (e.g. Fisher, 1979; Branney and Kokelaar, 2002; Cas et al. 2011). They pose a catastrophic geological hazard and have caused >90 000 deaths since 1600AD (Auker et al. 2013). Improved understanding of PDCs will enable us to better understand the explosive eruptions that generate them, improving our preparedness for future volcanic events. However, these deadly hazards are rarely observed up close and are difficult to analyse in real-time. To understand the flow dynamics of density currents we must use models and interpretations of their deposits (e.g. Smith N and Kokelaar, 2013; Rowley et al. 2014, Williams et al. 2014, Sulpizio et al. 2014; Lube et al. 2019, Smith G 2018, 2020).</p><p>The deposits of pyroclastic density currents, known as ‘ignimbrites’ can reveal important clues about how these deadly volcanic hazards behave in time and space Reverse grading in an ignimbrite can be interpreted in different ways (Branney & Kokelaar, 2002). It could record a growing eruption intensity through time - where increasingly larger clasts are introduced into the pyroclastic density current. Alternatively, it could record Kinematic sorting (the ‘muesli effect’) and transport processes within the current where larger particles became increasingly likely to be deposited as the current wanes (Palladino & Valentine,1995). The link between current dynamics and reverse grading is currently untested in aerated granular currents.</p><p>This project seeks to investigate the relationship between current dynamics and deposit architecture, specifically by considering granular sorting mechanisms in unidirectional flow. We will use an analogue flume (following methods in Rowley et. al., 2014, and Smith G et al., 2018, 2020) to explore how reverse grading and lateral grading may be related to changes in grain sizes at source versus kinematic sorting processes. A mix of grain sizes will be incorporated into the current via a hopper which allows for the starting composition of the current to be varied e.g. homogenous mix versus layered. Photographs of the deposit will be taken through the transparent sidewall of the flume and analysed using image analysis software. These experiments will be complimented by static tests of kinematic sorting, where a Perspex column will be sliced to reveal internal 3d architecture. This project will contribute to our understanding of lithofacies architecture in the field, and help to quantity how we interpret the sedimentation of ignimbrites.</p><p><em>References</em></p><p>Auker et al. (2013) https://doi.org/10.1186/2191-5040-2-2</p><p>Branney and Kokelaar (2002) https://doi.org/10.1144/GSL.MEM.2003.027</p><p>Cas et al. (2011) Bulletin of Volcanology 731583 https://doi.org/10.1007/s00445-011-0564-y</p><p>Fisher (1979) https://doi.org/10.1016/0377- 0273(79)90008-8    </p><p>Lube et al. (2019) https://doi.org/10.1038/s41561-019-0338-2</p><p>Palladino & Valentine (1995). https://doi.org/10.1016/0377-0273(95)00036-4</p><p>Rowley et al. (2014) https://doi.org/10.1007/s00445-014-0855-1</p><p>Smith N. and Kokelaar (2013) https://doi.org/10.1007/s00445-013-0768-4</p><p>Smith G. et al. (2018) https://doi.org/10.1007/s00445-018-1241-1</p><p>Smith, G. et al. (2020). https://doi.org/10.1038/s41467-020-16657-z</p>


2019 ◽  
Vol 73 (9) ◽  
pp. 2514
Author(s):  
Marwah Shahid ◽  
Tyler Fick ◽  
Athar Qureshi ◽  
Justin Georgekutty ◽  
Wilson Lam
Keyword(s):  

2014 ◽  
Vol 119 (7) ◽  
pp. 1614-1636 ◽  
Author(s):  
J.-Y. Chaufray ◽  
F Gonzalez-Galindo ◽  
F. Forget ◽  
M. Lopez-Valverde ◽  
F. Leblanc ◽  
...  

1994 ◽  
Vol 428 (2) ◽  
pp. 150-156 ◽  
Author(s):  
S. Dijkstra ◽  
E. Lohrmann ◽  
E. Van Kerkhove ◽  
P. Steels ◽  
R. Greger

2018 ◽  
Vol 19 (11) ◽  
pp. 3481 ◽  
Author(s):  
Philipp Glosse ◽  
Michael Föller

AMP-activated kinase (AMPK) is a serine/threonine kinase that is expressed in most cells and activated by a high cellular AMP/ATP ratio (indicating energy deficiency) or by Ca2+. In general, AMPK turns on energy-generating pathways (e.g., glucose uptake, glycolysis, fatty acid oxidation) and stops energy-consuming processes (e.g., lipogenesis, glycogenesis), thereby helping cells survive low energy states. The functional element of the kidney, the nephron, consists of the glomerulus, where the primary urine is filtered, and the proximal tubule, Henle’s loop, the distal tubule, and the collecting duct. In the tubular system of the kidney, the composition of primary urine is modified by the reabsorption and secretion of ions and molecules to yield final excreted urine. The underlying membrane transport processes are mainly energy-consuming (active transport) and in some cases passive. Since active transport accounts for a large part of the cell’s ATP demands, it is an important target for AMPK. Here, we review the AMPK-dependent regulation of membrane transport along nephron segments and discuss physiological and pathophysiological implications.


1995 ◽  
Vol 46 (1) ◽  
pp. 189 ◽  
Author(s):  
SG Schadlow ◽  
DP Hamilton

A process-based, hydrodynamic model that describes the mixing and transport processes in a stratified lake has been coupled to an ecological model to examine the relationship between the stratification and internal nutrient loading. The ecological model includes descriptions of algal production, nutrient cycling (including sediment release) and oxygen dynamics. An example is presented of the use of the model to examine interactions between stratification, sediment nutrient release and phytoplankton production when there is a major diversion of the inflow to a drinking water reservoir.


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