scholarly journals Persistence of Immunoglobulin M or Immunoglobulin G Antibody Responses toBorrelia burgdorferi10–20 Years after Active Lyme Disease

2001 ◽  
Vol 33 (6) ◽  
pp. 780-785 ◽  
Author(s):  
Robert A. Kalish ◽  
Gail McHugh ◽  
John Granquist ◽  
Barry Shea ◽  
Robin Ruthazer ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Immunoglobulin G ◽  
Immunoglobulin M ◽  
Antibody Responses

scholarly journals Detection of antibodies to decorin-binding protein A (DbpA) and DbpB after infection of dogs with Borrelia burgdorferi by tick challenge

2020 ◽  
Vol 32 (3) ◽  
pp. 481-485
Author(s):  
Darby G. Oldenburg ◽  
Dean A. Jobe ◽  
Steven D. Lovrich ◽  
Rhonda L. LaFleur ◽  
Douglas W. White ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Ixodes Scapularis ◽  
Binding Protein ◽  
Protein A ◽  
Immune Serum ◽  
Immunoglobulin M ◽  
Antibody Responses ◽  
Igg Antibodies ◽  
Serum Samples

We characterized the antibody response to decorin-binding protein A (DbpA) or DbpB from immune serum samples collected from 27 dogs infected with Borrelia burgdorferi by Ixodes scapularis ticks. Immunoglobulin M (IgM) antibodies to DbpA or DbpB were rarely detected, but high levels of IgG antibodies to DbpA were detected in 16 of 27 of the immune sera collected 1 mo after infection, 20 of 25 of the sera collected after 2 mo, and each of the 23, 17, or 11 serum samples evaluated after 3, 4, or 5 mo, respectively. In addition, IgG antibodies to DbpB were detected in 22 of 27 ( p = 0.005) tested dogs after 1 mo, and the frequency of detecting the antibodies thereafter closely mimicked the antibody responses to DbpA. Moreover, antibodies to DbpA or DbpB were not produced by dogs vaccinated with a whole-cell B. burgdorferi bacterin; removing the antibodies to DbpA by adsorption to recombinant DbpA (rDbpA) did not affect the reactivity detected by a rDbpB ELISA. Therefore, the findings from our preliminary study showed that antigenically distinct antibodies to DbpA or DbpB are produced reliably during canine infection with B. burgdorferi, and the response is not confounded by vaccination with a Lyme disease bacterin. Larger studies are warranted to more critically evaluate whether detecting the antibody responses can improve serodiagnostic confirmation of canine Lyme disease.

scholarly journals Immunoglobulin G and immunoglobulin M antibody responses of patients with malignancies to the O antigens of bacteria causing bacteremia.

1980 ◽  
Vol 12 (1) ◽  
pp. 60-62 ◽  
Author(s):  
P J Gannon ◽  
M J Surgalla ◽  
J E Fitzpatrick ◽  
E Neter
Keyword(s):  
Immunoglobulin G ◽  
Immunoglobulin M ◽  
Antibody Responses ◽  
O Antigens

scholarly journals Recognition of Multiple Antibody Epitopes throughout Borrelia burgdorferi p66, a Candidate Adhesin, in Patients with Early or Late Manifestations of Lyme Disease

2001 ◽  
Vol 69 (3) ◽  
pp. 1953-1956 ◽  
Author(s):  
Hyacinthe Ntchobo ◽  
Holly Rothermel ◽  
Wambui Chege ◽  
Allen C. Steere ◽  
Jenifer Coburn
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Disease Patient ◽  
Immunoglobulin M ◽  
Antibody Responses ◽  
Central Portion ◽  
Terminal Portion ◽  
Specific Recognition ◽  
Integrin Ligand ◽  
Antibody Epitopes

ABSTRACT Antibody responses to p66, a candidate integrin ligand ofBorrelia burgdorferi, were studied in 79 patients with early or late manifestations of Lyme disease. The central portion of p66 was previously shown to contain all of the information required for specific recognition of β3-chain integrins, but work by others had suggested that the C-terminal portion of the protein contains a single surface-exposed, immunodominant loop. In examining antibody responses to full-length p66 and to three overlapping fragments of the protein, we found that the majority of Lyme disease patients had immunoglobulin M (IgM) and/or IgG responses to p66 and that, particularly early in the disease, epitopes throughout p66 were recognized. Among patients with later manifestations of the illness, antibody responses to the C-terminal portion of the protein were more prominent. These results demonstrate that Lyme disease patient sera recognize epitopes throughout p66.

Immunoglobulin M and Immunoglobulin G Subclass Distribution of Anti-galactose-Alpha-1,3-Galactose and Anti-N-Glycolylneuraminic Acid Antibodies in Healthy Korean Adults

2021 ◽  
Author(s):  
Eun Jin Lee ◽  
Haneulnari Lee ◽  
Eun Mi Park ◽  
Hee Jung Kang ◽  
Sang Joon Kim ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Immunoglobulin M ◽  
Korean Adults ◽  
Immunoglobulin G Subclass

Detection of Immunoglobulin M and Immunoglobulin G Antibodies Against Orientia tsutsugamushi for Scrub Typhus Diagnosis and Serosurvey in Endemic Regions

2020 ◽  
Vol 57 (12) ◽  
pp. 1131-1134
Author(s):  
Mohan D. Gupte ◽  
Manish Gupte ◽  
Suchit Kamble ◽  
Arati Mane ◽  
Suvarna Sane ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Scrub Typhus ◽  
Immunoglobulin M ◽  
Orientia Tsutsugamushi

scholarly journals 2‐Tiered Antibody Testing for Early and Late Lyme Disease Using Only an Immunoglobulin G Blot with the Addition of a VlsE Band as the Second‐Tier Test

2010 ◽  
Vol 50 (1) ◽  
pp. 20-26 ◽  
Author(s):  
John A. Branda ◽  
Maria E. Aguero‐Rosenfeld ◽  
Mary Jane Ferraro ◽  
Barbara J. B. Johnson ◽  
Gary P. Wormser ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Immunoglobulin G ◽  
Antibody Testing ◽  
Second Tier

scholarly journals Age-Specific Immunoglobulin G (IgG) and IgA to Pneumococcal Protein Antigens in a Population in Coastal Kenya

2004 ◽  
Vol 72 (6) ◽  
pp. 3331-3335 ◽  
Author(s):  
Catherine Laine ◽  
Tabitha Mwangi ◽  
Claudette M. Thompson ◽  
Jacktone Obiero ◽  
Marc Lipsitch ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Protein A ◽  
Age Groups ◽  
Surface Protein ◽  
The Elderly ◽  
Antibody Responses ◽  
Sub Saharan Africa ◽  
Protein Antigens ◽  
Coastal Kenya ◽  
Iga Antibody

ABSTRACT Streptococcus pneumoniae is the primary etiological agent of community-acquired pneumonia and a major cause of meningitis and bacteremia. Three conserved pneumococcal proteins—pneumolysin, pneumococcal surface adhesin A (PsaA), and pneumococcal surface protein A (PspA)—are currently being investigated as vaccine candidates. Such protein-based vaccines, if proven effective, could provide a cheaper alternative to conjugate vaccine formulae. Few data from sub-Saharan Africa exist concerning the development of natural antibody to these antigens, however. To investigate the age-specific development of antiprotein immunoglobulin G (IgG) and IgA antibody responses, the sera of 220 persons 2 weeks to 84 years of age from coastal Kenya were assayed using enzyme-linked immunosorbent assays. IgG and IgA antibody responses to each antigen were observed in all age groups. Serum concentrations of IgG and IgA antibody responses to PspA and PdB (a recombinant toxoid derivative of pneumolysin), but not to PsaA, increased significantly with age (P < 0.001). No decline was observed in the sera of the elderly. Anti-protein IgG concentrations were only weakly correlated (0.30 < r < 0.56; P < 0.0001), as were IgA concentrations (0.24 < r < 0.54; P < 0.0001).

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