Experimental determination of modulation power of lung tissue for particle therapy

2021 ◽  
Author(s):  
Jan Michael Burg ◽  
Veronika Flatten ◽  
Matthias Witt ◽  
Larissa Derksen ◽  
Uli Weber ◽  
...  
Keyword(s):  
Lung Tissue ◽  
Ex Vivo ◽  
Ion Beam ◽  
Particle Beam ◽  
Particle Therapy ◽  
New Material ◽  
Carbon Ion Beam ◽  
Porcine Lungs ◽  
Micro Structures

Abstract In particle therapy of lung tumors, modulating effects on the particle beam may occur due to the microscopic structure of the lung tissue. These effects are caused by the heterogeneous nature of the lung tissue and cannot be completely taken into account during treatment planning, because these micro structures are too small to be fully resolved in the planning CT. In several publications, a new material parameter called modulation power (P mod ) was introduced to characterize the effect. For various artificial lung surrogates, this parameter was measured and published by other groups and ranges up to approximately 1000 µm. Studies investigating the influence of the modulation power on the dose distribution during irradiation are using this parameter in the rang of 100 to 800 µm. More precise measurements for P mod on real lung tissue have not yet been published. In this work, the modulation power of real lung tissue was measured using porcine lungs in order to produce more reliable data of P mod for real lung tissue. For this purpose, ex-vivo porcine lungs were frozen in a ventilated state and measurements in a carbon ion beam were performed. Due to the way the lungs were prepared and transferred to a solid state, the lung structures that modulate the beam could also be examined in detail using micro CT imaging. An optimization of the established methods of measuring the modulation power, which takes better account of the typical structures within lung tissue, was developed as well.

scholarly journals FLUKA particle therapy tool for Monte Carlo independent calculation of scanned proton and carbon ion beam therapy

2019 ◽  
Vol 64 (7) ◽  
pp. 075012 ◽  
Author(s):  
Wioletta S Kozłowska ◽  
Till T Böhlen ◽  
Caterina Cuccagna ◽  
Alfredo Ferrari ◽  
Francesco Fracchiolla ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Ion Beam ◽  
Particle Therapy ◽  
Carbon Ion ◽  
Ion Beam Therapy ◽  
Carbon Ion Beam ◽  
Independent Calculation

Determination of water absorbed dose in a carbon ion beam using thimble ionization chambers

1999 ◽  
Vol 44 (5) ◽  
pp. 1193-1206 ◽  
Author(s):  
G H Hartmann ◽  
O Jäkel ◽  
P Heeg ◽  
C P Karger ◽  
A Krießbach
Keyword(s):  
Ion Beam ◽  
Absorbed Dose ◽  
Ionization Chambers ◽  
Carbon Ion ◽  
Carbon Ion Beam

scholarly journals Particle Beam Therapy for Cancer of the Skull Base, Nasal Cavity, and Paranasal Sinus

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Nobuyoshi Fukumitsu
Keyword(s):  
Nasal Cavity ◽  
Skull Base ◽  
Paranasal Sinus ◽  
Ion Beam ◽  
Particle Beam ◽  
Ion Beams ◽  
Carbon Ion ◽  
Carbon Ion Beam ◽  
Future Direction ◽  
Particle Beam Therapy

Particle beam therapy has been rapidly developed in these several decades. Proton and carbon ion beams are most frequently used in particle beam therapy. Proton and carbon ion beam radiotherapy have physical and biological advantage to the conventional photon radiotherapy. Cancers of the skull base, nasal cavity, and paranasal sinus are rare; however these diseases can receive the benefits of particle beam radiotherapy. This paper describes the clinical review of the cancer of the skull base, nasal cavity, and paranasal sinus treated with proton and carbon ion beams, adding some information of feature and future direction of proton and carbon ion beam radiotherapy.

scholarly journals A Critical Review of Radiation Therapy: From Particle Beam Therapy (Proton, Carbon, and BNCT) to Beyond

2021 ◽  
Vol 11 (8) ◽  
pp. 825
Author(s):  
Yoshitaka Matsumoto ◽  
Nobuyoshi Fukumitsu ◽  
Hitoshi Ishikawa ◽  
Kei Nakai ◽  
Hideyuki Sakurai
Keyword(s):  
Radiation Therapy ◽  
Nuclear Reactions ◽  
Ion Beam ◽  
Multidisciplinary Treatment ◽  
Treatment Strategies ◽  
Particle Beam ◽  
Particle Therapy ◽  
High Dose ◽  
Therapeutic Effects ◽  
Particle Beam Therapy

In this paper, we discuss the role of particle therapy—a novel radiation therapy (RT) that has shown rapid progress and widespread use in recent years—in multidisciplinary treatment. Three types of particle therapies are currently used for cancer treatment: proton beam therapy (PBT), carbon-ion beam therapy (CIBT), and boron neutron capture therapy (BNCT). PBT and CIBT have been reported to have excellent therapeutic results owing to the physical characteristics of their Bragg peaks. Variable drug therapies, such as chemotherapy, hormone therapy, and immunotherapy, are combined in various treatment strategies, and treatment effects have been improved. BNCT has a high dose concentration for cancer in terms of nuclear reactions with boron. BNCT is a next-generation RT that can achieve cancer cell-selective therapeutic effects, and its effectiveness strongly depends on the selective 10B accumulation in cancer cells by concomitant boron preparation. Therefore, drug delivery research, including nanoparticles, is highly desirable. In this review, we introduce both clinical and basic aspects of particle beam therapy from the perspective of multidisciplinary treatment, which is expected to expand further in the future.

scholarly journals Stopping-power ratio of mouthpiece materials for charged-particle therapy in head and neck cancer

2021 ◽  
Author(s):  
Hiroaki Ikawa ◽  
Taku Inaniwa ◽  
Masashi Koto ◽  
Tapesh Bhattacharyya ◽  
Takashi Kaneko ◽  
...  
Keyword(s):  
Ion Beam ◽  
Acrylic Resin ◽  
Ethylene Vinyl Acetate ◽  
Peak Shift ◽  
Particle Therapy ◽  
Stopping Power ◽  
Conversion Table ◽  
Charged Particle Therapy ◽  
Carbon Ion Beam ◽  
The Difference

AbstractIn this study, the stopping-power ratios (SPRs) of mouthpiece materials were measured and the errors in the predicted SPRs based on conversion table values were further investigated. The SPRs of the five mouthpiece materials were predicted from their computed tomography (CT) numbers using a calibrated conversion table. Independently, the SPRs of the materials were measured from the Bragg peak shift of a carbon-ion beam passing through the materials. The errors in the SPRs of the materials were determined as the difference between the predicted and measured values. The measured SPRs (errors) of the Nipoflex 710™ and Bioplast™ ethylene–vinyl acetate copolymers (EVAs) were 0.997 (0.023) and 0.982 (0.007), respectively. The SPRs of the vinyl silicon impression material, light-curable resin, and bis-acrylic resin were 1.517 (0.134), 1.161 (0.068), and 1.26 (0.101), respectively. Among the five tested materials, the EVAs had the lowest SPR errors, indicating the highest human-tissue equivalency.

Structural and electrochemical characterization of carbon ion beam irradiated reduced graphene oxide and its application in voltammetric determination of norepinephrine

RSC Advances ◽  
2015 ◽  
Vol 5 (106) ◽  
pp. 87504-87511 ◽  
Author(s):  
Rosy Rosy ◽  
Fouran Singh ◽  
Rajendra N. Goyal
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Ion Beam ◽  
High Energy ◽  
Carbon Ion ◽  
Reduced Graphene ◽  
Sensitive Determination ◽  
Carbon Ion Beam

A high energy carbon ion beam irradiated sensor has been used for the sensitive determination of norepinephrine.

scholarly journals PV-0422: Direct determination of kQ in a clinical carbon ion beam using water calorimetry

2017 ◽  
Vol 123 ◽  
pp. S223
Author(s):  
J.M. Osinga-Blättermann ◽  
U. Ankerhold ◽  
S. Brons ◽  
S. Greilich ◽  
O. Jäkel ◽  
...  
Keyword(s):  
Ion Beam ◽  
Direct Determination ◽  
Carbon Ion ◽  
Carbon Ion Beam

scholarly journals Study of an Online Plan Verification Method and the Sensitivity of Plan Delivery Accuracy to Different Beam Parameter Errors in Proton and Carbon Ion Radiotherapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Jun Zhao ◽  
Zhi Chen ◽  
Xianwei Wu ◽  
Ying Xing ◽  
Yongqiang Li
Keyword(s):  
Particle Number ◽  
Ion Beam ◽  
Reconstruction Algorithm ◽  
Spot Size ◽  
Particle Therapy ◽  
Beam Parameter ◽  
Carbon Ion ◽  
Carbon Ion Beam ◽  
Beam Parameters ◽  
Delivery Accuracy

For scanning beam particle therapy, the plan delivery accuracy is affected by spot size deviation, position deviation and particle number deviation. Until now, all plan verification systems available for particle therapy have been designed for pretreatment verification. The purpose of this study is to introduce a method for online plan delivery accuracy checks and to evaluate the sensitivity of plan delivery accuracy to different beam parameter errors. A program was developed using MATLAB to reconstruct doses from beam parameters recorded in log files and to compare them with the doses calculated by treatment planning system (TPS). Both carbon ion plans and proton plans were evaluated in this study. The dose reconstruction algorithm is verified by comparing the dose from the TPS with the reconstructed dose under the same beam parameters. The sensitivity of plan delivery accuracy to different beam parameter errors was analyzed by comparing the dose reconstructed from the pseudo plans that manually added errors with the original plan dose. For the validation of dose reconstruction algorithm, mean dose difference between the reconstructed dose and the plan dose were 0.70% ± 0.24% and 0.51% ± 0.25% for carbon ion beam and proton beam, respectively. According to our simulation, the delivery accuracy of the carbon ion plan is more sensitive to spot position deviation and particle number deviation, and the delivery accuracy of the proton plan is more sensitive to spot size deviation. To achieve a 90% gamma pass rate with 3 mm/3% criteria, the average spot size deviation, position deviation, particle number deviation should be within 23%, 1.9 mm, and 1.5% and 20%, 2.1 mm, and 1.6% for carbon ion beam and proton beam, respectively. In conclusion, the method that we introduced for online plan delivery verification is feasible and reliable. The sensitivity of plan delivery accuracy to different errors was clarified for our system. The methods used in this study can be easily repeated in other particle therapy centers.

scholarly journals Air leaks: stapling affects porcine lungs biomechanics

2021 ◽  
Author(s):  
Benedicte Bonnet ◽  
Ilyass Tabiai ◽  
George Rakovich ◽  
Frederick P Gosselin ◽  
Isabelle Villemure
Keyword(s):  
Lung Tissue ◽  
Ex Vivo ◽  
Lower Lobe ◽  
Image Correlation ◽  
In Vivo Studies ◽  
P Value ◽  
Maximum Shear Strain ◽  
Air Leaks ◽  
Volume Curve ◽  
Porcine Lungs

During thoracic operations, surgical staplers resect cancerous tumors and seal the spared lung. However, post-operative air leaks are undesirable clinical consequences: staple legs wound lung tissue. Subsequent to this trauma, air leaks from lung tissue into the pleural space. This affects the lung's physiology and patients' recovery. The objective is to biomechanically and visually characterize porcine lung tissue with and without staples in order to gain knowledge on air leakage following pulmonary resection. Therefore, a syringe pump filled with air inflates and deflates eleven porcine lungs cyclically without exceeding 10 cmH2O of pressure. Cameras capture stereo-images of the deformed lung surface at regular intervals while a microcontroller simultaneously records the alveolar pressure and the volume of air pumped. The raw images are then used to compute tri-dimensional displacements and strains with the Digital Image Correlation method (DIC). Air bubbles originated at staple holes of inner row from exposed porcine lung tissue due to torn pleural on costal surface. Compared during inflation, left upper or lower lobe resections have similar compliance (slope of the pressure vs volume curve), which are 9% lower than healthy lung compliance. However, lower lobes statistically burst at lower pressures than upper lobes (p-value<0.046) in ex vivo conditions confirming previous clinical in vivo studies. In parallel, the lung deformed mostly in the vicinity of staple holes and presented maximum shear strain near the observed leak location. To conclude, a novel technique DIC provided concrete evidence of the post-operative air leaks biomechanics. Further studies could investigate causal relationships between the mechanical parameters and the development of an air leak.

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