Antioxidant and Anticancer Activity Tests of “Pasote” Leaf Water Extracts (Dysphania ambrosioides L.) by In Vitro Method in Leukemia Cancer Cells

Abstract In this study, ultrasonically driven biosynthesis of zinc oxide nanoparticles (ZnO NPs) using Swietenia macrophylla seed ethyl acetate fraction (SMEAF) has been reported. X-ray powder diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) analyses confirmed the presence of a pure hexagonal wurtzite structure of ZnO. Field emission scanning electron microscope images revealed the formation of uniquely identifiable uniform rice-shaped biologically synthesized ZnOSMEAF particles. The particle sizes of the biosynthesized NPs ranged from 262 to 311 nm. The underlying mechanisms for the biosynthesis of ZnOSMEAF under ultrasound have been proposed based on FTIR and XRD results. The anticancer activity of the as-prepared ZnOSMEAF was investigated against HCT-116 human colon cancer cell lines via methyl thiazolyl tetrazolium assay. ZnOSMEAF exhibited significant anticancer activity against colon cancer cells with higher potency than ZnO particles prepared using the chemical method and SMEAF alone. Exposure of HCT-116 colon cancer cells to ZnOSMEAF promoted a remarkable reduction in cell viability in all the tested concentrations. This study suggests that green sonochemically induced ZnO NPs using medicinal plant extract could be a potential anticancer agent for biomedical applications.

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Easily Available, Amphiphilic Diiron Cyclopentadienyl Complexes Exhibit in Vitro Anticancer Activity in 2D and 3D Human Cancer Cells through Redox Modulation Triggered by CO Release

Chemistry - A European Journal ◽

10.1002/chem.202101048 ◽

2021 ◽

Author(s):

Lorenzo Biancalana ◽

Michele De Franco ◽

Gianluca Ciancaleoni ◽

Stefano Zacchini ◽

Guido Pampaloni ◽

...

Keyword(s):

Anticancer Activity ◽

Cancer Cells ◽

Human Cancer ◽

Redox Modulation ◽

Human Cancer Cells ◽

Cyclopentadienyl Complexes ◽

2D And 3D

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NBM-HD-1: A Novel Histone Deacetylase Inhibitor with Anticancer Activity

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/781417 ◽

2012 ◽

Vol 2012 ◽

pp. 1-11 ◽

Cited By ~ 8

Author(s):

Wei-Jan Huang ◽

Yu-Chih Liang ◽

Shuang-En Chuang ◽

Li-Ling Chi ◽

Chi-Yun Lee ◽

...

Keyword(s):

Anticancer Activity ◽

Cancer Cells ◽

Anticancer Agents ◽

Xenograft Model ◽

Cyclin B1 ◽

Dependent Manner ◽

Cell Cycle Regulators ◽

Anticancer Activities ◽

Gene Expressions

HDAC inhibitors (HDACis) have been developed as promising anticancer agents in recent years. In this study, we synthesized and characterized a novel HDACi, termed NBM-HD-1. This agent was derived from the semisynthesis of propolin G, isolated from Taiwanese green propolis (TGP), and was shown to be a potent suppressor of tumor cell growth in human breast cancer cells (MCF-7 and MDA-MB-231) and rat glioma cells (C6), with an IC50ranging from 8.5 to 10.3 μM. Western blot demonstrated that levels of p21(Waf1/Cip1), gelsolin, Ac-histone 4, and Ac-tubulin markedly increased after treatment of cancer cells with NBM-HD-1. After NBM-HD-1 treatment for 1–4 h, p-PTEN and p-AKT levels were markedly decreased. Furthermore, we also found the anticancer activities of NBM-HD-1 in regulating cell cycle regulators. Treatment with NBM-HD-1,p21(Waf1/Cip1)gene expression had markedly increased whilecyclin B1andD1gene expressions had markedly decreased. On the other hand, we found that NBM-HD-1 increased the expressions of tumor-suppressor genep53in a dose-dependent manner. Finally, we showed that NBM-HD-1 exhibited potent antitumor activity in a xenograft model. In conclusion, this study demonstrated that this compound, NBM-HD-1, is a novel and potent HDACi with anticancer activityin vitroandin vivo.

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Lemongrass Extract Possesses Potent Anticancer Activity Against Human Colon Cancers, Inhibits Tumorigenesis, Enhances Efficacy of FOLFOX, and Reduces Its Adverse Effects

Integrative Cancer Therapies ◽

10.1177/1534735419889150 ◽

2019 ◽

Vol 18 ◽

pp. 153473541988915 ◽

Cited By ~ 2

Author(s):

Ivan Ruvinov ◽

Christopher Nguyen ◽

Benjamin Scaria ◽

Caleb Vegh ◽

Ola Zaitoon ◽

...

Keyword(s):

Colorectal Cancer ◽

Colon Cancer ◽

Anticancer Activity ◽

Cancer Cells ◽

Human Colon ◽

Dependent Manner ◽

Anticancer Efficacy ◽

Colon Cancers ◽

Induced Apoptosis

Current chemotherapeutics for metastatic colorectal cancers have limited success and are extremely toxic due to nonselective targeting. Some natural extracts have been traditionally taken and have shown anticancer activity. These extracts have multiple phytochemicals that can target different pathways selectively in cancer cells. We have shown previously that lemongrass ( Cymbopogon citratus) extract is effective at inducing cell death in human lymphomas. However, the efficacy of lemongrass extract on human colorectal cancer has not been investigated. Furthermore, its interactions with current chemotherapies for colon cancer is unknown. In this article, we report the anticancer effects of ethanolic lemongrass extract in colorectal cancer models, and importantly, its interactions with FOLFOX and Taxol. Lemongrass extract induced apoptosis in colon cancer cells in a time and dose-dependent manner without harming healthy cells in vitro. Oral administration of lemongrass extract was well tolerated and effective at inhibiting colon cancer xenograft growth in mice. It enhanced the anticancer efficacy of FOLFOX and, interestingly, inhibited FOLFOX-related weight loss in animals given the combination treatment. Furthermore, feeding lemongrass extract to APCmin/+ transgenic mice led to the reduction of intestinal tumors, indicating its preventative potential. Therefore, this natural extract has potential to be developed as a supplemental treatment for colorectal cancer.

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Anticancer Activity of Cynomorium coccineum

Cancers ◽

10.3390/cancers10100354 ◽

2018 ◽

Vol 10 (10) ◽

pp. 354 ◽

Cited By ~ 7

Author(s):

Mouna Sdiri ◽

Xiangmin Li ◽

William Du ◽

Safia El-Bok ◽

Yi-Zhen Xie ◽

...

Keyword(s):

Cell Cycle ◽

Cell Death ◽

Anticancer Activity ◽

Cancer Cells ◽

Cell Lines ◽

Cancer Cell ◽

Cell Cycle Progression ◽

Cycle Progression

The extensive applications of Cynomorium species and their rich bioactive secondary metabolites have inspired many pharmacological investigations. Previous research has been conducted to examine the biological activities and numerous interesting pharmaceutical activities have been reported. However, the antitumor activities of these species are unclear. To understand the potential anticancer activity, we screened Cynomorium coccineum and Cynomorium songaricum using three different extracts of each species. In this study, the selected extracts were evaluated for their ability to decrease survival rates of five different cancer cell lines. We compared the cytotoxicity of the three different extracts to the anticancer drug vinblastine and one of the most well-known medicinal mushrooms Amaurederma rude. We found that the water and alcohol extracts of C. coccineum at the very low concentrations possessed very high capacity in decreasing the cancer cells viability with a potential inhibition of tumorigenesis. Based on these primitive data, we subsequently tested the ethanol and the water extracts of C. coccineum, respectively in in vitro and in vivo assays. Cell cycle progression and induction of programmed cell death were investigated at both biological and molecular levels to understand the mechanism of the antitumor inhibitory action of the C. coccineum. The in vitro experiments showed that the treated cancer cells formed fewer and smaller colonies than the untreated cells. Cell cycle progression was inhibited, and the ethanol extract of C. coccineum at a low concentration induced accumulation of cells in the G1 phase. We also found that the C. coccineum’s extracts suppressed viability of two murine cancer cell lines. In the in vivo experiments, we injected mice with murine cancer cell line B16, followed by peritoneal injection of the water extract. The treatment prolonged mouse survival significantly. The tumors grew at a slower rate than the control. Down-regulation of c-myc expression appeared to be associated with these effects. Further investigation showed that treatment with C. coccineum induced the overexpression of the tumor suppressor Foxo3 and other molecules involved in inducing autophagy. These results showed that the C. coccineum extract exerts its antiproliferative activity through the induction of cell death pathway. Thus, the Cynomorium plants appear to be a promising source of new antineoplastic compounds.

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Incorporation of Zataria multiflora essential oil into chitosan biopolymer nanoparticles: A nanoemulsion based delivery system to improve the in-vitro efficacy, stability and anticancer activity of ZEO against breast cancer cells

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2019.12.058 ◽

2020 ◽

Vol 143 ◽

pp. 382-392 ◽

Cited By ~ 9

Author(s):

Fahimeh Salehi ◽

Hossein Behboudi ◽

Gholamreza Kavoosi ◽

Sussan K. Ardestani

Keyword(s):

Breast Cancer ◽

Essential Oil ◽

Anticancer Activity ◽

Cancer Cells ◽

Delivery System ◽

Breast Cancer Cells ◽

Zataria Multiflora ◽

Chitosan Biopolymer

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In vitro anticancer activity of AIEgens

Biomaterials Science ◽

10.1039/c9bm00881k ◽

2019 ◽

Vol 7 (9) ◽

pp. 3855-3865

Author(s):

Feng Yin ◽

Bobo Gu ◽

Jingxu Li ◽

Nishtha Panwar ◽

Yong Liu ◽

...

Keyword(s):

Stem Cells ◽

Cancer Stem Cells ◽

Anticancer Activity ◽

Cancer Cells ◽

Tumor Invasion ◽

Structural Modifications ◽

Image Guided ◽

Chemotherapy Agents

AIEgens possess superior cytotoxicity, tumor invasion, and hemolysis against cancer cells and cancer stem cells. Simple structural modifications enable them as highly biocompatible, image-guided chemotherapy agents.

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