Electrical conductivity spectra of hepatic tumors reflect hepatocellular carcinoma progression in mice

2020 ◽  
Vol 6 (6) ◽  
pp. 065019
Author(s):  
Sachin Shetty ◽  
Anushree U ◽  
Rajesh Kumar ◽  
Sanjay Bharati
Keyword(s):  
Hepatocellular Carcinoma ◽  
Electrical Conductivity ◽  
Hepatic Tumors ◽  
Conductivity Spectra

scholarly journals Targeted enzyme assisted chemotherapy (TEAC) – a novel microRNA-guided and selenium-based regimen to specifically eradicate hepatocellular carcinoma

2021 ◽  
Author(s):  
Arun Kumar Selvam ◽  
Rim Jawad ◽  
Roberto Gramignoli ◽  
Adnane Achour ◽  
Hugh Salter ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Lines ◽  
Human Hepatocytes ◽  
Hepatic Tumors ◽  
Therapeutic Approaches ◽  
Specific Induction ◽  
Specific Cytotoxicity ◽  
Hcc Cells ◽  
Novel Therapeutic ◽  
Target Effects

AbstractDespite progress in the treatment of non-visceral malignancies, the prognosis remains poor for malignancies of visceral organs and novel therapeutic approaches are urgently required. Here we introduce a novel therapeutic regimen by treatment with Se-methylselenocysteine (MSC) and concomitant tumor-specific induction of Kynurenine aminotransferase 1 (KYAT1) in hepatocellular carcinoma (HCC) cell lines, using either vector-based and/or lipid nanoparticle-mediated delivery of mRNA. Supplementation of MSC in KYAT1 overexpressed cells resulted in significantly increased cytotoxicity as compared to MSC alone. Furthermore, microRNA antisense targeted sites for miR122, known to be widely expressed in normal hepatocytes whilst downregulated in hepatocellular carcinoma, were added to specifically limit cytotoxicity in HCC cells, thereby limiting off-target effects. KYAT1 expression was significantly reduced in cells with high levels of miR122 supporting the concept of miR-guided induction of tumor-specific cytotoxicity. The addition of alpha-ketoacid favored the production of methylselenol, enhancing the cytotoxic efficacy of MSC in HCC cells, with no effects on primary human hepatocytes. Altogether, the proposed regimen offers great potential to safely and specifically target hepatic tumors that are currently untreatable.

Influence of Cr substitution on structural, magnetic and electrical conductivity spectra of LaFeO3

2015 ◽  
Vol 646 ◽  
pp. 924-931 ◽  
Author(s):  
A. Paul Blessington Selvadurai ◽  
V. Pazhanivelu ◽  
C. Jagadeeshwaran ◽  
R. Murugaraj ◽  
I. Panneer Muthuselvam ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Cr Substitution ◽  
Conductivity Spectra
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