scholarly journals Using the Olfactory System as an In Vivo Model To Study Traumatic Brain Injury and Repair

2014 ◽  
Vol 31 (14) ◽  
pp. 1277-1291 ◽  
Author(s):  
Elizabeth Steuer ◽  
Michele L. Schaefer ◽  
Leonardo Belluscio
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Olfactory System ◽  
In Vivo Model ◽  
Injury And Repair

scholarly journals Xenon Improves Neurologic Outcome and Reduces Secondary Injury Following Trauma in an In Vivo Model of Traumatic Brain Injury*

2015 ◽  
Vol 43 (1) ◽  
pp. 149-158 ◽  
Author(s):  
Rita Campos-Pires ◽  
Scott P. Armstrong ◽  
Anne Sebastiani ◽  
Clara Luh ◽  
Marco Gruss ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Neurologic Outcome ◽  
In Vivo Model ◽  
Secondary Injury

Behavioral effect of dipeptide NGF mimetic GK-2 in an in vivo model of rat traumatic brain injury and its neuroprotective and regenerative properties in vitro

2014 ◽  
Vol 125 (5) ◽  
pp. 375-379 ◽  
Author(s):  
Elena V. Stelmashook ◽  
Elisaveta E. Genrikhs ◽  
Svetlana V. Novikova ◽  
Igor V. Barskov ◽  
Tatyana A. Gudasheva ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Behavioral Effect ◽  
In Vivo Model

scholarly journals Neurodegeneration and Sensorimotor Deficits in the Mouse Model of Traumatic Brain Injury

2017 ◽  
Author(s):  
Saurav Bhowmick ◽  
Veera D'Mello ◽  
Nizmi Ponery ◽  
P.M. Abdul-Muneer
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Caspase 3 ◽  
Annexin V ◽  
Screen Test ◽  
In Vivo Model ◽  
Tunel Staining ◽  
Sensorimotor Deficits ◽  
Fluid Percussion Injury

Traumatic brain injury (TBI) can result in persistent sensorimotor and cognitive deficits, which occur through a cascade of deleterious pathophysiological events over time. In this study, we investigated the hypothesis that neurodegeneration caused by TBI leads to impairments in sensorimotor function. TBI induces the activation of the caspase-3 enzyme, which triggers cell apoptosis in an in vivo model of fluid percussion injury (FPI). We analyzed caspase-3 mediated apoptosis by TUNEL staining and PARP and annexin V western blotting. We correlated the neurodegeneration with sensorimotor deficits by conducting the animal behavioral tests including grid walk, balance beam, inverted screen test, and climb test. Our study demonstrated that the excess cell death or neurodegeneration correlated with the neuronal dysfunction and sensorimotor impairments associated with TBI.

scholarly journals Co-Ultra PEALut Enhances Endogenous Repair Response Following Moderate Traumatic Brain Injury

2021 ◽  
Vol 22 (16) ◽  
pp. 8717
Author(s):  
Michela Campolo ◽  
Rosalia Crupi ◽  
Marika Cordaro ◽  
Salvatore Massimo Cardali ◽  
Alessio Ardizzone ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Neurotrophic Factors ◽  
Therapeutic Agent ◽  
In Vivo Model ◽  
Memory Recall ◽  
Behavioral Testing ◽  
Moderate Traumatic Brain Injury ◽  
Mature Neurons

This study aimed to assess the neuro-regenerative properties of co-ultramicronized PEALut (Glialia®), composed of palmitoylethanolamide (PEA) and the flavonoid luteolin (Lut), in an in vivo model of traumatic brain injury (TBI) and patients affected by moderate TBI. An increase in neurogenesis was seen in the mice at 72 h and 7 days after TBI. The co-ultra PEALut treatment helped the neuronal reconstitution process to restore the basal level of both novel and mature neurons; moreover, it induced a significant upregulation of the neurotrophic factors, which ultimately led to progress in terms of memory recall during behavioral testing. Moreover, our preliminary findings in a clinical trial suggested that Glialia® treatment facilitated neural recovery on working memory. Thus, co-ultra PEALut (Glialia®) could represent a valuable therapeutic agent for intensifying the endogenous repair response in order to better treat TBI.

An Activatable NIR‐II Nanoprobe for In Vivo Early Real‐Time Diagnosis of Traumatic Brain Injury

2019 ◽  
Vol 59 (1) ◽  
pp. 247-252 ◽  
Author(s):  
Chunyan Li ◽  
Wanfei Li ◽  
Huanhuan Liu ◽  
Yejun Zhang ◽  
Guangcun Chen ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Real Time ◽  
Time Diagnosis

scholarly journals In vivo imaging of rapid deformation and strain in an animal model of traumatic brain injury

2006 ◽  
Vol 39 (6) ◽  
pp. 1086-1095 ◽  
Author(s):  
Philip V. Bayly ◽  
Erin E. Black ◽  
Rachel C. Pedersen ◽  
Elizabeth P. Leister ◽  
Guy M. Genin
Keyword(s):  
Traumatic Brain Injury ◽  
Animal Model ◽  
Brain Injury ◽  
In Vivo Imaging ◽  
Rapid Deformation
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