scholarly journals Relationships Between Iron Status, Cognitive Performance, and Smoking Cessation

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 898-898
Author(s):  
Laili Boozary ◽  
Lisa De Stefano ◽  
Amy Barnett ◽  
Joseph Waring ◽  
Darla Kendzor ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Cognitive Performance ◽  
Iron Status ◽  
Negative Relationship ◽  
Small Sample ◽  
Reward Processing ◽  
Nonlinear Relationship ◽  
Negative Consequences ◽  
Quit Smoking ◽  
Dopaminergic Pathways

Abstract Objectives Smoking cessation research suggests that women are more likely than men to respond to financial incentives to quit smoking, despite having lower rates of smoking cessation overall. Animal models suggest that iron deficiency, which is more prevalent in women, may alter dopaminergic pathways involved in both reward processing and addiction. The present study examines the extent to which iron status impacts ability to quit smoking and performance on a battery of cognitive tasks, including tasks assessing learning and decision-making which depend on the integrity of the dopaminergic pathways. Methods Participants were recruited from a local smoking cessation clinic and followed for 6 months as they received counseling to quit smoking. Visits included a baseline appointment, as well as 1- and 6-month follow up visits. At each appointment, participants performed cognitive tests, including the serial reaction time task (SRT) and probabilistic selection task (PST), with concurrent EEG, then gave a small sample of blood. Smoking behavior was examined using time to relapse (TTR), which was the week (1–26) in which the participant relapsed, if relapse occurred. Iron status variables of interest were hemoglobin (Hb) and percentile of the NHANES III age- and race-adjusted distributions of serum ferritin (sFtP). Correlations examined the associations between iron status variables and reaction times (RTs) on the SRT and PST, choice behavior on PST, and TTR. Results TTR was positively related to sFtP (r = 0.79, P < .005). Regarding the cognitive measures, there was a nonlinear relationship between sFtP and RT for the SRT task: participants with sFtP at or below the 45th percentile had a negative relationship with RT, while those with sFtP above the 55th percentile had a positive one. Hb was negatively correlated with learning from negative consequences in the PST. In addition, RTs for high-conflict choices and correct responses had a nonlinear relationship with sFtP like that found with the SRT. Conclusions Variations in iron affect smoking cessation as well as cognitive performance. Being low in iron may represent an additional burden to a woman who attempts to quit smoking. Funding Sources TSET Health Promotion Research Center - Oklahoma Tobacco Settlement Endowment Trust (TSET; Grant # r21–02) and NCI Support Grant P30CA225520.

scholarly journals 4199 A pilot randomized controlled trial of precision care for smoking cessation in the Southern Community Cohort Study

2020 ◽  
Vol 4 (s1) ◽  
pp. 105-105
Author(s):  
Nicole Senft ◽  
Maureen Sanderson ◽  
Rebecca Selove ◽  
William J. Blot ◽  
Rachel F. Tyndale ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Smoking Cessation ◽  
Cohort Study ◽  
Conflicts Of Interest ◽  
Controlled Trial ◽  
Small Sample ◽  
Future Research ◽  
Polygenic Risk Score ◽  
Nicotine Replacement ◽  
Quit Smoking

OBJECTIVES/GOALS: Precision care may engage smokers and providers in treatment but is understudied in the community. We piloted guideline-based care (GBC) alone or with Respiragene, a lung cancer polygenic risk score (PRS, 1-10), or metabolism-informed choice of medication using the nicotine metabolite ratio (NMR). METHODS/STUDY POPULATION: Daily smokers (n = 58) with stored biospecimens in the Southern Community Cohort Study were randomized 1:1:1 to GBC, PRS, or NMR, counseled to quit smoking, and co-selected FDA-approved cessation medication (nicotine replacement, varenicline) with a tobacco counselor. In PRS, precision motivational counseling was guided by PRS (i.e., lung cancer risk 10-40-fold that of never-smokers). In NMR, precision medication recommendations consisted of varenicline for faster metabolizers (NMR≥0.31) and nicotine replacement for slow metabolizers (NMR<0.31). Feasibility was defined as achieving at least 50% provider engagement (med prescription) and at least 50% patient engagement (self-reported med use). RESULTS/ANTICIPATED RESULTS: Participants were median age 59, 72% female, 81% Black, 60% with incomes <$15,000; median cigarettes/day was 15 (IQR 8-20) and 52% reported time-to-first cigarette <5 minutes, illustrating moderate nicotine dependence. Providers confirmed medication prescriptions for 40% of patients (32% GBC, 50% PRS, 37% NMR) and 83% of patients reported using medication (prescribed or unprescribed) during the study (90% GBC, 80% PRS, 79% NMR). At 6-month follow-up, 27% (n = 15) reported cessation (39% GBC, 16% PRS, 26% NMR). Among persistent smokers, 46% reported smoking at least 50% fewer cigarettes/day compared to baseline (45% GBC, 38% PRS, 57% NMR). Small sample size precluded statistical comparisons. DISCUSSION/SIGNIFICANCE OF IMPACT: Precision interventions to quit smoking are feasible for community smokers, who engaged at high rates. However, only 40% of providers supported patients’ quit attempts with medication prescriptions. Future research should test strategies to raise provider engagement in precision smoking treatment. CONFLICT OF INTEREST DESCRIPTION: R.F.T. has consulted for Quinn Emmanual and Apotex on unrelated topics. H.A.T. reported providing input on design for a phase 3 trial of cytisine proposed by Achieve Life Sciences and being a principal investigator of National Institutes of Health–sponsored studies for smoking cessation that include medications donated by the manufacturers. Other authors declare no potential conflicts of interest.

scholarly journals Perioperative digital behaviour change interventions for reducing alcohol consumption, improving dietary intake, increasing physical activity and smoking cessation: a scoping review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Katarina Åsberg ◽  
Marcus Bendtsen
Keyword(s):  
Physical Activity ◽  
Smoking Cessation ◽  
Behaviour Change ◽  
Scoping Review ◽  
Text Messaging ◽  
Text Message ◽  
Feasibility Studies ◽  
Small Sample ◽  
Small Sample Sizes ◽  
Randomised Controlled

Abstract Background Evidence suggests that unhealthy lifestyle behaviours are modifiable risk factors for postoperative complications. Digital behaviour change interventions (DBCIs), for instance text messaging programs and smartphone apps, have shown promise in achieving lifestyle behaviour change in a wide range of clinical populations, and it may therefore be possible to reduce postoperative complications by supporting behaviour change perioperatively using digital interventions. This scoping review was conducted in order to identify existing research done in the area of perioperative DBCIs for reducing alcohol consumption, improving dietary intake, increasing physical activity and smoking cessation. Main text This scoping review included eleven studies covering a range of surgeries: bariatric, orthopaedic, cancer, transplantation and elective surgery. The studies were both randomised controlled trials and feasibility studies and investigated a diverse set of interventions: one game, three smartphone apps, one web-based program and five text message interventions. Feasibility studies reported user acceptability and satisfaction with the behaviour change support. Engagement data showed participation rates ranged from 40 to 90%, with more participants being actively engaged early in the intervention period. In conclusion, the only full-scale randomised controlled trial (RCT), text messaging ahead of bariatric surgery did not reveal any benefits with respect to adherence to preoperative exercise advice when compared to a control group. Two of the pilot studies, one text message intervention, one game, indicated change in a positive direction with respect to alcohol and tobacco outcomes, but between group comparisons were not done due to small sample sizes. The third pilot-study, a smartphone app, found between group changes for physical activity and alcohol, but not with respect to smoking cessation outcomes. Conclusion This review found high participant satisfaction, but shows recruitment and timing-delivery issues, as well as low retention to interventions post-surgery. Small sample sizes and the use of a variety of feasibility outcome measures prevent the synthesis of results and makes generalisation difficult. Future research should focus on defining standardised outcome measures, enhancing patient engagement and improving adherence to behaviour change prior to scheduled surgery.

scholarly journals Caffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
E. Aidman ◽  
M. Balin ◽  
K. Johnson ◽  
S. Jackson ◽  
G. M. Paech ◽  
...  
Keyword(s):  
Real Time ◽  
Cognitive Performance ◽  
Small Sample ◽  
Night Time ◽  
Double Blind ◽  
Infra Red ◽  
Procedural Decisions ◽  
Performance Gains ◽  
The Impact ◽  
Modest Reduction

AbstractCaffeine is widely used to promote alertness and cognitive performance under challenging conditions, such as sleep loss. Non-digestive modes of delivery typically reduce variability of its effect. In a placebo-controlled, 50-h total sleep deprivation (TSD) protocol we administered four 200 mg doses of caffeine-infused chewing-gum during night-time circadian trough and monitored participants' drowsiness during task performance with infra-red oculography. In addition to the expected reduction of sleepiness, caffeine was found to disrupt its degrading impact on performance errors in tasks ranging from standard cognitive tests to simulated driving. Real-time drowsiness data showed that caffeine produced only a modest reduction in sleepiness (compared to our placebo group) but substantial performance gains in vigilance and procedural decisions, that were largely independent of the actual alertness dynamics achieved. The magnitude of this disrupting effect was greater for more complex cognitive tasks.

Internet-based intervention compared to brief intervention for smoking cessation in Brazil: a pilot study (Preprint)

2021 ◽  
Author(s):  
Nathalia Machado ◽  
Henrique Gomide ◽  
Heder Bernardino ◽  
Telmo Ronzani
Keyword(s):  
Smoking Cessation ◽  
Brief Intervention ◽  
Small Sample Size ◽  
Statistical Significance ◽  
Healthcare Providers ◽  
Intervention Group ◽  
Small Sample ◽  
The Internet ◽  
Intention To Treat ◽  
Internet Based Intervention

BACKGROUND Smoking is still the leading cause of preventable death. Governments and healthcare providers should make available more and accessible resources to help tobacco users stop. OBJECTIVE This study describes a pilot longitudinal study that evaluated the efficacy of a computerized intervention compared to the brief intervention for smoking cessation among Brazilians. METHODS Smokers were recruited and randomly assigned to one of the two intervention groups. RESULTS The results showed similar rates of cessation and reduction for both intervention groups. The internet-based intervention was a little more effective for smoking cessation, while the brief intervention was more effective in reducing the number of cigarettes smoked per day. Despite this, this difference was small and had no statistical significance even after adjusting for intention-to-treat analysis. These results should be interpreted with caution, especially due to the small sample size. CONCLUSIONS Forty-nine smokers were enrolled in this study (25 in the brief intervention group; 24 in the internet-based intervention group). The mean age was 44.46 years old; most were male (59.2%), had elementary school (44.9%), smoked an average of 14.5 cigarettes per day, had a mean score of 4.65 for nicotine dependence, and score of 5.7 for motivation to quit. Measures were drawn from comparing cessation rate, motivation score and sought treatment between groups. Thirty-five participants answered the follow up 1 and 19 answered to the second.

Alliance network size, partner diversity, and knowledge creation in small biotech firms

2015 ◽  
Vol 21 (5) ◽  
pp. 614-626 ◽  
Author(s):  
Woojin Yoon ◽  
Diane Y. Lee ◽  
Jaeyong Song
Keyword(s):  
Knowledge Creation ◽  
Negative Relationship ◽  
Network Size ◽  
Negative Consequences ◽  
Alliance Networks ◽  
Organizational Type ◽  
Alliance Network ◽  
Biotech Industry ◽  
Insight Into ◽  
Balanced Network

AbstractThis paper investigates the effects on knowledge creation of network size and partner diversity formed through alliance relationships. These effects are tested empirically in the biotech industry setting, which is representative of industries that emphasize external collaboration. Using patent count as a proxy of knowledge creation, Poisson regression was employed to test our predictions empirically. The statistical results show an inverted U-shaped relationship between network size and knowledge creation. In addition, a negative relationship was observed between partner diversity and knowledge creation. This research suggests that small biotech firms should strive to achieve a balanced network size. Knowledge creation is better promoted in these firms through alliances with firms of similar organizational type. The value of this research lies in the fact that it provides new insight into properties of alliance networks by highlighting potentially negative consequences of having an oversized alliance network and partner diversity.

scholarly journals Associations between Practitioner Personality and Client Quit Rates in Smoking Cessation Behavioural Support Interventions

2017 ◽  
Vol 13 (2) ◽  
pp. 103-109 ◽  
Author(s):  
Heather L. Gainforth ◽  
Sarita Y. Aujla ◽  
Emma Beard ◽  
Emma Croghan ◽  
Robert West
Keyword(s):  
Smoking Cessation ◽  
Outcome Measure ◽  
Success Rates ◽  
Specific Training ◽  
Five Dimensions ◽  
Quit Smoking ◽  
Stop Smoking ◽  
Random Intercept ◽  
Stop Smoking Services ◽  
Multi Level

Introduction:There is wide variation in the success rates of practitioners employed to help smokers to stop, even once a range of potential confounding factors has been taken into account.Aim:This paper examined whether personality characteristics of practitioners might play a role success rates.Methods:Data from 1,958 stop-smoking treatment episodes in two stop-smoking services (SSS) involving 19 stop-smoking practitioners were used in the analysis. The outcome measure was clients’ biochemically verified quit status 4 weeks after the target quit date. The five dimensions of personality, as assessed by the Ten-Item Personality Inventory, were included as predictor variables: openness, conscientiousness, agreeableness, extraversion, and neuroticism. A range of client and other practitioner characteristics were used as covariates. A sensitivity analysis was conducted to determine if managers' ratings of practitioner personality were also associated with clients’ quit status.Results:Multi-level random intercept models indicated that clients of practitioners with a higher extraversion score had greater odds of being abstinent at four weeks (self-assessed: OR = 1.10, 95% CI = 1.01–1.19; manager-assessed: OR = 1.32, 95% CI = 1.21–1.44).Conclusions:More extraverted stop smoking practitioners appear to have greater success in advising their clients to quit smoking. Findings need to be confirmed in larger practitioner populations, other SSS, and in different smoking cessation contexts. If confirmed, specific training may be needed to assist more introverted stop smoking practitioners.

Stress Spillover in Policing and Negative Relationship Functioning for Law Enforcement Marriages

2018 ◽  
Vol 26 (2) ◽  
pp. 246-252 ◽  
Author(s):  
Brooke McQuerrey Tuttle ◽  
Zachary Giano ◽  
Michael J. Merten
Keyword(s):  
Law Enforcement ◽  
Occupational Stress ◽  
Work Stress ◽  
Police Officers ◽  
Negative Relationship ◽  
Well Being ◽  
Relationship Functioning ◽  
Negative Consequences ◽  
Marital Functioning ◽  
Unique Type

The nature of police work includes toxic work environments and uncertain danger which imparts a unique type of occupational stress spillover or the transfer of stress from work life to home life for law enforcement officers. Work stress places officers at risk for negative health and psychosocial outcomes. While it has been shown that occupational stress can compromise the well-being of police officers, little is known about how spillover can effect other areas of life for officers such as marital relationships. This study investigates the association between work demands, emotional stress spillover, and marital functioning in a law enforcement sample. Data from 1,180 married law enforcement respondents to the Police Officer Questionnaire which included 148 items assessing work stress, health, family, and support were examined. Responses were analyzed using regression analyses. Results showed that career demands and emotional spillover were statistically significant predictors of the variance in marital functioning. Social and emotional spillover of work-related stress carries negative consequences for communication and emotion regulation within law enforcement marriages.

scholarly journals Smoking Cessation Services by Community Pharmacists: Real-World Practice in Thailand

2021 ◽  
Vol 18 (22) ◽  
pp. 11890
Author(s):  
Sunee Lertsinudom ◽  
Pentipa Kaewketthong ◽  
Tamonwan Chankaew ◽  
Dujrudee Chinwong ◽  
Surarong Chinwong
Keyword(s):  
Smoking Cessation ◽  
Community Pharmacy ◽  
Real World ◽  
Community Pharmacists ◽  
Self Report ◽  
P Value ◽  
Quit Smoking ◽  
Smoking Cessation Services ◽  
Before And After ◽  
Exhaled Carbon Monoxide

This study aimed to report the effectiveness of community pharmacy smoking cessation services in 13 health regions in Thailand using a retrospective data-collecting method from the Foundation of Community Pharmacy database. The participants were smokers aged at least 18 years. The outcomes were the abstinence of smoking at least 30 consecutive days by self-report only and self-report with exhaled CO level <7 ppm (if available), the number of cigarettes smoked daily, exhaled carbon monoxide (exhaled CO), and % peak expiratory flow rate (%PEFR); smokers measured these outcomes before and after receiving the smoking cessation services. Of 58 community pharmacies, 532 smokers (93% male, mean age of 42.4 ± 14.9 years) received smoking cessation services from community pharmacists. Of 235 smokers with complete data, 153 (28.8%, 153/532) smokers reported smoking abstinence by self-report. The mean number of cigarettes smoked daily reduced from 15.3 ± 8.7 to 1.9 ± 3.8 cigarettes, p-value < 0.001. The exhaled CO levels of smokers significantly reduced from 11.7 ± 5.9 ppm to 7.2 ± 4.4 ppm, p-value < 0.001. The %PEFR also significantly increased from 84.2 ± 19.4 to 89.5 ± 19.5, p-value < 0.001. In conclusion, Thai community pharmacy smoking cessation services could aid smokers to quit smoking. This study is the outcome of the real-world community pharmacy smoking cessation service; policymakers should consider this service to be included in the national healthcare policy.

scholarly journals Characteristics and Predictors of Abstinence Among Smokers of a Smoking Cessation Clinic in Hunan China

2021 ◽  
Vol 9 ◽  
Author(s):  
Yina Hu ◽  
Jianghua Xie ◽  
Xiaochang Chang ◽  
Jianhua Chen ◽  
Wei Wang ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Statistical Significance ◽  
Operational Experience ◽  
Individual Counseling ◽  
Quit Smoking ◽  
Binary Regression Analysis ◽  
Counseling And Assessment ◽  
Cessation Clinic ◽  
Smoking Cessation Clinic

Background: More than 300 million smokers make China the largest cigarette consumer globally, which is a huge economic burden. Smoking cessation (SC) clinics can offer counseling and follow-up services. The operational experience of SC clinics in China needs to be summarized and improved based on research evidence.Purpose: The objectives of this study were to describe quit rates among attendees of SC clinics in Hunan and assess predictors of successful SC.Methods: The participants in this study were smokers who visited the SC clinic of Hunan Cancer Hospital from February 1, 2015 to September 30, 2018. Individuals who received individual counseling and assessment from the SC clinic staff and were willing to quit smoking were eligible for inclusion. Those with critical illness or cancer were excluded. Application of smoking cessation clinic registration form (unified by Chinese Center for Disease Control and Prevention) was used to assess participants at the consultation. Follow-ups and counseling were performed over telephone at 1 week, 1 month, and 3 months after the initial cessation consultation or in times of need. Successful SC was checked for at 3 months after the start of SC.Results: A total of 328 smokers (mean age 45.67 ± 12.38 years) had participated. The abstinence rate at 3 months was 28.4%. Binary regression analysis revealed significant independent predictors to be the total numbers of SC follow up sessions, previous SC attempts, and participants' decision on when to quit smoking (The relative to quit immediately group, quit within 30 days, quit after 30 days, and undecided quit were less likely to succeed in quitting. while quit within seven days had no statistical significance.Conclusion: SC clinics can achieve a desirably high quit rate. Participant's previous attempts at quitting, three or more follow-ups, and the decision to quit immediately or within seven days were factors helpful in predicting the success of SC.

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