O181 SERUM C-REACTIVE PROTEIN CAN BE AN EARLY PREDICTOR OF LENGHT OF HOSPITAL STAY AFTER MINIMALLY INVASIVE OESOPHAGECTOMY

2019 ◽  
Vol 32 (Supplement_2) ◽  
Author(s):  
Gabriele Corsi ◽  
Krashna Patel ◽  
Omar Abbassi ◽  
Zobia Gudkalli ◽  
David O’Hara ◽  
...  
Keyword(s):  
Length Of Stay ◽  
Minimally Invasive ◽  
Hospital Stay ◽  
Acute Phase Protein ◽  
C Reactive Protein ◽  
Operative Morbidity ◽  
Reactive Protein ◽  
Operative Recovery ◽  
Minimally Invasive Oesophagectomy ◽  
Overall Mortality

Abstract Aim Oesophagectomy is associated with a significant number of potential complications affecting the lenght of the post-operative recovery. Serum C-reactive protein (CRP) is an acute phase protein which has been linked to early detection of post-operative complications, including but not limited to anastomotic leak. The aim of this retrospective study was to investigate the value of CRP elevation in the early post-operative days as a predictor of lenght of Hospital stay after minimally invasive oesophagectomy for cancer. Background and Methods The study group included 88 patients undergoing minimally invasive oesophagectomy for cancer from September 2017 to April 2019. CRP values on post-operative day 1,3,5 and 7 were retrieved and correlated to overall lenght of stay. Post-operative morbidity and mortality were also recorded. Results The approach was fully minimally invasive in 65 patients (74%) and hybrid in the remaining 23 (26%). The median length of stay was 11 days (IQR, 6-105 days) with overall mortality of 3.4% (n=3). Gastro-intestinal complications occurred in 15 patients (17%). The overall surgical or endoscopic re-intervention rate was 13.6% (n=12). The median CRP value was 54.8, 167, 143 and 134 mg/L, respectively on day 1,3,5 and 7. There was a positive correlation between CRP and length of stay on day 1, 3 and 7. A cut-off value of 167 mg/L on day 3 appeared to be a significant predictor of increased lenght of stay (12.8 vs 23.3 days, p=0.008). Conclusion CRP levels above 167mg/L on post-operative day 3 were associated with a prolonged lenght of hospital stay in our group of patients. Elevated CRP in the early post-operative period could represent a useful tool to predict lenght of stay after minimally invasive oesophagectomy.

scholarly journals C-reactive protein as predictor of anastomotic complications after minimally invasive oesophagectomy

2019 ◽  
Vol 15 (1) ◽  
pp. 46 ◽  
Author(s):  
Lumir Kunovsky ◽  
Vladimir Prochazka ◽  
Filip Marek ◽  
Roman Svaton ◽  
Martina Farkasova ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
C Reactive Protein ◽  
Anastomotic Complications ◽  
Reactive Protein ◽  
Minimally Invasive Oesophagectomy

scholarly journals Effects of statins on clinical outcomes in hospitalized patients with community-acquired pneumonia

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052093858
Author(s):  
Rony M. Zeenny ◽  
Hanine Mansour ◽  
Wissam K Kabbara ◽  
Nibal Chamoun ◽  
Myriam Audi ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Length Of Stay ◽  
Hospital Length ◽  
Community Acquired Pneumonia ◽  
Hospital Length Of Stay ◽  
Comorbid Conditions ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Significant Difference ◽  
Chronic Use

Objective We evaluated the effect of chronic use of statins based on C-reactive protein (CRP) levels and hospital length of stay (LOS) in patients admitted with community-acquired pneumonia (CAP). Methods We conducted a retrospective study over 12 months at a teaching hospital in Lebanon comparing patients with CAP taking chronic statins with patients not taking statins. Included patients with CAP were older than age 18 years and had two CRP level measures during hospitalization. CURB-65 criteria were used to assess the severity of pneumonia. A decrease in CRP levels on days 1 and 3, LOS, and normalization of fever were used to assess the response to antibiotics. Results Sixty-one patients were taking statins and 90 patients were not taking statins. Patients on statins had significantly more comorbid conditions; both groups had comparable CURB-65 scores. In both groups, no statistically significant difference was seen for the decrease in CRP level on days 1 and 3 and LOS. No difference in days to normalization of fever was detected in either group. Conclusion No association was found between the chronic use of statins and CRP levels, LOS, or days to fever normalization in patients with CAP.

scholarly journals Clinical practice of mininally invasive gynaecological surgeries

2018 ◽  
Vol 21 (2) ◽  
pp. 19-23
Author(s):  
Binaya Raj Bhandari ◽  
Ranjana Shrestha ◽  
Binita Pradhan
Keyword(s):  
Clinical Practice ◽  
Minimally Invasive ◽  
Hospital Stay ◽  
Laparoscopic Hysterectomy ◽  
Descriptive Study ◽  
Routine Practice ◽  
Gynaecological Surgery ◽  
Patient Demographics ◽  
Common Operation ◽  
Operative Recovery

Introduction: Endoscopic gynaecological surgery which is a routine practice in outer world since last 40 years, is still at earlier phase in Nepal. This study was done to know the clinical practice of minimally invasive gynaecological surgeries in Minimally Invasive Diagnostic and Therapeutic (MIDAT) hospital. Methods: A hospital based descriptive study was conducted in gynaecological department of MIDAT hospital over 16 months period from 1st Bhadra 2071 to 30th Poush 2072 (17th August 2014 to 14th January 2016) among 115 women who underwent minimally invasive gynaecological surgeries (MIGS). Patient demographics, types of surgeries, indications of laparoscopy and hysteroscopy, reason for laparoscopic conversion, complications of surgeries and hospital stay were analyzed. Results: There were total 115 minimally invasive gynaecological surgeries done in MIDAT hospital during study period. Laparoscopic gynaecological surgeries and hysteroscopy were performed in 86 (75%) and in 29 (25%) women respectively. Among laparoscopy, laparoscopic hysterectomy {31 (36%)} was the more common operation. During laparoscopy, conversion to open was done in nine (10.5%) patients. Complications of MIGS were seen in three (3.5%) women. Conclusions: MIGS has acceptable morbidity, smooth post operative recovery and shorter hospital stay. In recent time, MIGS is gradually becoming popular in Nepal.   

scholarly journals Acute phase proteins in bitches subjected to conventional and minimally invasive ovariohysterectomy

2018 ◽  
Vol 38 (11) ◽  
pp. 2124-2128 ◽  
Author(s):  
Elizabeth M.S. Schmidt ◽  
Camila P. Rubio ◽  
Funmilola Thomas ◽  
João C.P. Ferreira ◽  
David P. Eckersall
Keyword(s):  
Minimally Invasive ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Serum Haptoglobin ◽  
Hemoglobin Binding ◽  
Mixed Breed ◽  
Significant Difference ◽  
Haptoglobin Concentration

ABSTRACT: The aim of this study was to evaluate and to compare the possible inflammatory changes by screening acute phase proteins concentrations in healthy bitches subjected to ovariohysterectomy. Minimally invasive and conventional (laparotomy) ovariohysterectomies were performed in 17 client-owned adult female mixed breed dogs. Nine animals were subjected to minimally invasive and eight animals to conventional ovariohysterectomy. Blood samples were taken before surgery, 24, 48 hours, and seven days postoperatively. Serum C-reactive concentration was determined by a commercial ELISA kit and serum haptoglobin concentration was measured via hemoglobin binding assay, both previously validated for use in dogs. As the data did not meet the normal distribution criteria, the nonparametric Kruskall-Wallis was performed to compare quantitative variables between groups. One-way ANOVA and the Friedman test were used for multiple comparisons between time points, with a P<0.05 considered significant. C-reactive protein concentration was significantly different (P<0.0001) at 24 hours postoperatively between groups. There was no significant difference in haptoglobin concentration between groups. C-reactive protein and haptoglobin concentrations were significantly different at 24 and 48 hours postoperatively for minimally invasive and conventional ovariohisterectomies. These findings provided an overview of the short-term inflammatory effects produced by minimally invasive and conventional ovariohysterectomies.

scholarly journals THE LIVER AS THE SITE OF C-REACTIVE PROTEIN FORMATION

1966 ◽  
Vol 123 (2) ◽  
pp. 365-378 ◽  
Author(s):  
J. Hurlimann ◽  
G. J. Thorbecke ◽  
G. M. Hochwald
Keyword(s):  
Amino Acid ◽  
Serum Proteins ◽  
Acute Phase Protein ◽  
Human Beings ◽  
C Reactive Protein ◽  
Amino Acid Incorporation ◽  
Reactive Protein ◽  
Acid Incorporation ◽  
Phase Protein

The site of formation of C-reactive protein (CxRP, CRP) has been studied with tissues from rabbits, monkeys, and human beings. Rabbits and monkeys were stimulated to produce the acute phase protein by injection of turpentine, croton oil, endotoxin, paratyphoid-typhoid vaccine, or pneumococci. C14-amino acid incorporation in vitro was demonstrated by means of autoradiography of immunoelectrophoretic patterns made with culture fluids. It was found that among many different tissues tested liver was the only tissue which incorporated C14-lysine and isoleucine into CxRP or CRP. Only livers taken 16 to 24 hr after various stimuli were active; livers from normal animals or from animals killed 3 to 9 hr after stimulation did not produce detectable amounts of CxRP. Inflamed muscle from the injection site did not show C14-amino acid incorporation into CxRP. Several human tissues were also cultured, and a few liver cultures found to contain labeled CRP. The formation of CxRP or CRP by the liver was always accompanied by enhanced C14-amino acid incorporation into other serum proteins, but the reverse was not always found.

Serum Amyloid A and C-Reactive Protein Concentrations Are Differently Associated with Markers of Autoimmunity in Patients with Primary Sjögren’s Syndrome

2009 ◽  
Vol 36 (11) ◽  
pp. 2487-2490 ◽  
Author(s):  
MARJA PERTOVAARA ◽  
JUULIA JYLHÄVÄ ◽  
HANNU UUSITALO ◽  
JUHANI PUKANDER ◽  
HEIKKI HELIN ◽  
...  
Keyword(s):  
Acute Phase ◽  
Serum Amyloid A ◽  
Acute Phase Protein ◽  
Inverse Correlation ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Amyloid A ◽  
Phase Protein ◽  
Sicca Symptoms ◽  
Protein Serum

Objective.Primary Sjögren’s syndrome (pSS) is an autoimmune disease in which the concentration of the acute-phase protein serum C-reactive protein (CRP) is low. We investigated whether levels of another acute-phase protein, serum amyloid A (SAA), are increased in patients with pSS and whether the immunological markers in patients with pSS are associated with variation in SAA levels.Methods.Serum SAA concentrations were measured by ELISA in 74 patients with pSS and in 56 control subjects with sicca symptoms.Results.Median SAA levels did not differ significantly between patients with pSS and subjects with sicca symptoms. In patients with pSS SAA concentrations correlated significantly with age, leukocyte count, CRP, interleukin 6, and C4. Unlike CRP, there was a significant inverse correlation between SAA and serum IgG levels and anti-SSA antibody titers, as well as a trend towards an inverse correlation between SAA and antinuclear antibody and rheumatoid factor titers.Conclusion.Our data imply that high SAA production could constitute a protective element in pSS: high SAA levels inhibit in particular various signs of B cell hyperreactivity, i.e., IgG and autoantibody production.

Utility of C-reactive protein as predictive biomarker of anastomotic leak after minimally invasive esophagectomy

2018 ◽  
Vol 403 (2) ◽  
pp. 235-244 ◽  
Author(s):  
Emanuele Asti ◽  
Gianluca Bonitta ◽  
Matteo Melloni ◽  
Stefania Tornese ◽  
Pamela Milito ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Anastomotic Leak ◽  
Minimally Invasive Esophagectomy ◽  
Predictive Biomarker ◽  
C Reactive Protein ◽  
Invasive Esophagectomy ◽  
Reactive Protein

scholarly journals Blockage of interleukin-1β with canakinumab in patients with Covid-19

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Lorenza Landi ◽  
Claudia Ravaglia ◽  
Emanuele Russo ◽  
Pierluigi Cataleta ◽  
Maurizio Fusari ◽  
...  
Keyword(s):  
Overall Survival ◽  
Prospective Study ◽  
Controlled Trials ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Randomized Controlled ◽  
Duration Of Hospitalization ◽  
Observational Cohort ◽  
Absolute Lymphocyte Counts ◽  
Overall Mortality

AbstractThere is the urgent need to study the effects of immunomodulating agents as therapy for Covid-19. An observational, cohort, prospective study with 30 days of observation was carried out to assess clinical outcomes in 88 patients hospitalized for Covid-19 pneumonia and treated with canakinumab (300 mg sc). Median time from diagnosis of Covid-19 by viral swab to administration of canakinumab was 7.5 days (range 0–30, IQR 4–11). Median PaO2/FiO2 increased from 160 (range 53–409, IQR 122–210) at baseline to 237 (range 72–533, IQR 158–331) at day 7 after treatment with canakinumab (p < 0.0001). Improvement of oxygen support category was observed in 61.4% of cases. Median duration of hospitalization following administration of canakinumab was 6 days (range 0–30, IQR 4–11). At 7 days, 58% of patients had been discharged and 12 (13.6%) had died. Significant differences between baseline and 7 days were observed for absolute lymphocyte counts (mean 0.60 vs 1.11 × 109/L, respectively, p < 0.0001) and C-reactive protein (mean 31.5 vs 5.8 mg/L, respectively, p < 0.0001).Overall survival at 1 month was 79.5% (95% CI 68.7–90.3). Oxygen-support requirements improved and overall mortality was 13.6%. Confirmation of the efficacy of canakinumab for Covid-19 warrants further study in randomized controlled trials.

C-reactive protein quantification in porcine saliva: A minimally invasive test for pig health monitoring

2009 ◽  
Vol 181 (3) ◽  
pp. 261-265 ◽  
Author(s):  
A.M. Gutiérrez ◽  
S. Martínez-Subiela ◽  
P.D. Eckersall ◽  
J.J. Cerón
Keyword(s):  
Minimally Invasive ◽  
Health Monitoring ◽  
Protein Quantification ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Invasive Test ◽  
Pig Health
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