scholarly journals Omega-3 supplementation improves isometric strength but not muscle anabolic and catabolic signaling in response to resistance exercise in healthy older adults

2020 ◽  
Author(s):  
Sebastiaan Dalle ◽  
Evelien Van Roie ◽  
Charlotte Hiroux ◽  
Mathias Vanmunster ◽  
Walter Coudyzer ◽  
...  
Keyword(s):  
Older Adults ◽  
Resistance Exercise ◽  
Corn Oil ◽  
Knee Extensor ◽  
Muscle Volume ◽  
Isometric Strength ◽  
Muscle Quality ◽  
Omega 3 ◽  
Muscle Inflammation ◽  
Before And After

Abstract Old skeletal muscle exhibits decreased anabolic sensitivity, eventually contributing to muscle wasting. Besides anabolism, also muscle inflammation and catabolism are critical players in regulating the old skeletal muscle’s sensitivity. Omega-3 fatty acids (ω-3) are an interesting candidate to reverse anabolic insensitivity via anabolic actions. Yet, it remains unknown whether ω-3 also attenuates muscle inflammation and catabolism. The present study investigates the effect of ω-3 supplementation on muscle inflammation and metabolism (anabolism/catabolism) upon resistance exercise (RE). Twenty-three older adults (OA) (65-84yr;8♀) were randomized to receive ω-3 (~3g·d -1) or corn oil (PLAC) and engaged in a 12-wk RE program (3x·wk -1). Before and after intervention, muscle volume, strength and systemic inflammation were assessed, and muscle biopsies were analysed for markers of anabolism, catabolism and inflammation. Isometric knee-extensor strength increased in ω-3 (+12.2%), but not in PLAC (-1.4%; pinteraction=0.015), whereas leg press strength improved in both conditions (+27.1%; ptime<0.001). RE, but not ω-3, decreased inflammatory (p65NF-κB) and catabolic (FOXO1, LC3b) markers, and improved muscle quality. Yet, muscle volume remained unaffected by RE and ω-3. Accordingly, muscle anabolism (mTORC1) and plasma CRP remained unchanged by RE and ω-3, whereas serum IL-6 tended to decrease in ω-3 (pinteraction=0.07). These results show that, despite no changes in muscle volume, RE-induced gains in isometric strength can be further enhanced by ω-3. However, ω-3 did not improve RE-induced beneficial catabolic or inflammatory adaptations. Irrespective of muscle volume, gains in strength (primary criterion for sarcopenia) might be explained by changes in muscle quality due to muscle inflammatory or catabolic signaling.

Muscle quality. II. Effects of strength training in 65- to 75-yr-old men and women

1999 ◽  
Vol 86 (1) ◽  
pp. 195-201 ◽  
Author(s):  
B. L. Tracy ◽  
F. M. Ivey ◽  
D. Hurlbut ◽  
G. F. Martel ◽  
J. T. Lemmer ◽  
...  
Keyword(s):  
Strength Training ◽  
Older Women ◽  
Knee Extensor ◽  
Older Men ◽  
Quadriceps Muscle ◽  
Muscle Volume ◽  
Muscle Quality ◽  
Men And Women ◽  
Leg Extension ◽  
Before And After

To determine the effects of strength training (ST) on muscle quality (MQ, strength/muscle volume of the trained muscle group), 12 healthy older men (69 ± 3 yr, range 65–75 yr) and 11 healthy older women (68 ± 3 yr, range 65–73 yr) were studied before and after a unilateral leg ST program. After a warm-up set, four sets of heavy-resistance knee extensor ST exercise were performed 3 days/wk for 9 wk on the Keiser K-300 leg extension machine. The men exhibited greater absolute increases in the knee extension one-repetition maximum (1-RM) strength test (75 ± 2 and 94 ± 3 kg before and after training, respectively) and in quadriceps muscle volume measured by magnetic resonance imaging (1,753 ± 44 and 1,955 ± 43 cm3) than the women (42 ± 2 and 55 ± 3 kg for the 1-RM test and 1,125 ± 53 vs. 1,261 ± 65 cm3 for quadriceps muscle volume before and after training, respectively, in women; both P < 0.05). However, percent increases were similar for men and women in the 1-RM test (27 and 29% for men and women, respectively), muscle volume (12% for both), and MQ (14 and 16% for men and women, respectively). Significant increases in MQ were observed in both groups in the trained leg (both P < 0.05) and in the 1-RM test for the untrained leg (both P < 0.05), but no significant differences were observed between groups, suggesting neuromuscular adaptations in both gender groups. Thus, although older men appear to have a greater capacity for absolute strength and muscle mass gains than older women in response to ST, the relative contribution of neuromuscular and hypertrophic factors to the increase in strength appears to be similar between genders.

scholarly journals LOW-LOAD RESISTANCE EXERCISE IMPROVES COGNITIVE FUNCTION IN OLDER ADULTS

2018 ◽  
Vol 24 (2) ◽  
pp. 125-129 ◽  
Author(s):  
Amanda Veiga Sardeli ◽  
Marina Lívia Venturini Ferreira ◽  
Lucas do Carmo Santos ◽  
Marília de Souza Rodrigues ◽  
Alfredo Damasceno ◽  
...  
Keyword(s):  
Older Adults ◽  
Response Time ◽  
Resistance Exercise ◽  
Load Resistance ◽  
Level Of Evidence ◽  
Healthy Older Adults ◽  
Results Of Treatment ◽  
Low Load ◽  
Before And After ◽  
Exercise Induced

ABSTRACT Introduction: Resistance exercise (RE) training is widely recommended for increasing muscle strength and mass in older adults. RE is also a potential stimulus to improve cognitive functions (CF), but the best protocol for this purpose is unknown. Objective: To compare the effects of different RE protocols on CF in the same group of individuals. Methods: Twenty-four older adults were randomized (cross over) to control (CON) and lower limb RE protocols with high load (HL - 80% of 1RM), low load (LL - 30% of 1RM) and LL with blood flow restriction (LL-BFR - 30% of 1RM and 50% BFR). For CF assessment, participants underwent the Stroop test before and after each RE protocol. Results: Reduction in response time for Stroop neutral stimuli was greater after LL (effect size (ES) = -0.92) compared to CON (ES = -0.18) and HL (ES = -0.03), but was not different from LL-BFR (ES = -0.24). The reduced response time was associated with reduced parasympathetic modulation and increased cardiac output across protocols. Conclusion: LL was the most effective RE protocol to improve CF of older adults and a potential beneficial effect of LL-BFR on CF (non-significant) was identified. Therefore, LL resistance exercise appears to stimulate acute cognitive improvements in healthy older adults, probably through exercise-induced optimal autonomic modulation changes. Level of Evidence I; Therapeutic studies-Investigating the results of treatment.

scholarly journals Regional and muscle-specific adaptations in knee extensor hypertrophy using flywheel versus conventional weight-stack resistance exercise

2019 ◽  
Vol 44 (8) ◽  
pp. 827-833 ◽  
Author(s):  
Tommy R. Lundberg ◽  
Maria T. García-Gutiérrez ◽  
Mirko Mandić ◽  
Mats Lilja ◽  
Rodrigo Fernandez-Gonzalo
Keyword(s):  
Resistance Exercise ◽  
Muscle Hypertrophy ◽  
Vastus Lateralis ◽  
Knee Extensor ◽  
Rectus Femoris ◽  
Knee Extension ◽  
Knee Extensors ◽  
Cross Sectional ◽  
Proximal Site ◽  
Before And After

This study compared the effects of the most frequently employed protocols of flywheel (FW) versus weight-stack (WS) resistance exercise (RE) on regional and muscle-specific adaptations of the knee extensors. Sixteen men (n = 8) and women (n = 8) performed 8 weeks (2–3 days/week) of knee extension RE employing FW technology on 1 leg (4 × 7 repetitions), while the contralateral leg performed regular WS training (4 × 8–12 repetitions). Maximal strength (1-repetition maximum (1RM) in WS) and peak FW power were determined before and after training for both legs. Partial muscle volume of vastus lateralis (VL), vastus medialis (VM), vastus intermedius (VI), and rectus femoris (RF) were measured using magnetic resonance imaging. Additionally, quadriceps cross-sectional area was assessed at a proximal and a distal site. There were no differences (P > 0.05) between FW versus WS in muscle hypertrophy of the quadriceps femoris (8% vs. 9%), VL (10% vs. 11%), VM (6% vs. 8%), VI (5% vs. 5%), or RF (17% vs. 17%). Muscle hypertrophy tended (P = 0.09) to be greater at the distal compared with the proximal site, but there was no interaction with exercise method. Increases in 1RM and FW peak power were similar across legs, yet the increase in 1RM was greater in men (31%) than in women (20%). These findings suggest that FW and WS training induces comparable muscle-specific hypertrophy of the knee extensors. Given that these robust muscular adaptations were brought about with markedly fewer repetitions in the FW compared with WS, it seems FW training can be recommended as a particularly time-efficient exercise paradigm.

scholarly journals Effects of strength training and detraining on knee extensor strength, muscle volume and muscle quality in elderly women

AGE ◽  
2012 ◽  
Vol 35 (5) ◽  
pp. 1899-1904 ◽  
Author(s):  
Cleiton Silva Correa ◽  
Bruno Manfredini Baroni ◽  
Régis Radaelli ◽  
Fábio Juner Lanferdini ◽  
Giovani Dos Santos Cunha ◽  
...  
Keyword(s):  
Strength Training ◽  
Elderly Women ◽  
Knee Extensor ◽  
Muscle Volume ◽  
Muscle Quality ◽  
Knee Extensor Strength ◽  
Training And Detraining

Muscle quality index improves with resistance exercise training in older adults

2014 ◽  
Vol 53 ◽  
pp. 1-6 ◽  
Author(s):  
Maren S. Fragala ◽  
David H. Fukuda ◽  
Jeffrey R. Stout ◽  
Jeremy R. Townsend ◽  
Nadia S. Emerson ◽  
...  
Keyword(s):  
Older Adults ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Quality Index ◽  
Muscle Quality ◽  
Resistance Exercise Training

Muscle-Power Quality: Does Sex or Race Affect Movement Velocity in Older Adults?

2006 ◽  
Vol 14 (4) ◽  
pp. 411-422 ◽  
Author(s):  
Neil A. Doldo ◽  
Matthew J. Delmonico ◽  
Jason A. Bailey ◽  
Brian D. Hand ◽  
Matthew C. Kostek ◽  
...  
Keyword(s):  
Older Adults ◽  
African Americans ◽  
Muscle Power ◽  
Knee Extensor ◽  
Knee Extension ◽  
Relative Strength ◽  
Extensor Muscle ◽  
Muscle Volume ◽  
Movement Velocity ◽  
Knee Extensor Strength

To determine sex and race differences in muscle power per unit of muscle contraction, knee-extensor muscle power normalized for knee-extensor muscle volume was measured in 79 middle-aged and older adults (30 men and 49 women, age range 50–85 years). Results revealed that women displayed a 38% faster peak movement velocity than men and African Americans had a 14% lower peak movement velocity than Whites of a similar age when expressed per unit of involved muscle (p< .001). As expected, men exhibited greater knee-extensor strength and peak power per unit of muscle than women, but women had a faster knee-extension movement velocity per unit of muscle than men at the same relative strength level. Moreover, African Americans had greater knee-extensor muscle volume than Whites but exhibited lower knee-extensor strength and lower movement velocity per unit of muscle when tested at the same relative strength levels.

Aerobic exercise does not compromise muscle hypertrophy response to short-term resistance training

2013 ◽  
Vol 114 (1) ◽  
pp. 81-89 ◽  
Author(s):  
Tommy R. Lundberg ◽  
Rodrigo Fernandez-Gonzalo ◽  
Thomas Gustafsson ◽  
Per A. Tesch
Keyword(s):  
Resistance Exercise ◽  
Muscle Hypertrophy ◽  
Citrate Synthase ◽  
Vastus Lateralis ◽  
Knee Extensor ◽  
Muscle Size ◽  
Mrna Levels ◽  
Cross Sectional ◽  
Before And After

This study tested the hypothesis that chronic aerobic and resistance exercise (AE+RE) would elicit greater muscle hypertrophy than resistance exercise only (RE). Ten men (25 ± 4 yr) performed 5 wk unilateral knee extensor AE+RE. The opposing limb was subjected to RE. AE completed 6 hr prior to RE consisted of ∼45 min one-legged cycle ergometry. RE comprised 4 × 7 maximal concentric-eccentric knee extensions. Various indexes of in vivo knee extensor function were measured before and after training. Magnetic resonance imaging (MRI) assessed m. quadricep femoris (QF) cross-sectional area (CSA), volume, and signal intensity (SI). Biopsies obtained from m. vastus lateralis determined fiber CSA, enzyme levels, and gene expression of myostatin, atrogin-1, MuRF-1, PGC-1α, and VEGF. Increases ( P < 0.05) in isometric strength and peak power, respectively, were comparable in AE+RE (9 and 29%) and RE (11 and 24%). AE+RE showed greater increase (14%; P < 0.05) in QF volume than RE (8%). Muscle fiber CSA increased 17% after AE+RE ( P < 0.05) and 9% after RE ( P > 0.05). QF SI increased (12%; P < 0.05) after AE+RE, but not RE. Neither AE+RE nor RE showed altered mRNA levels. Citrate synthase activity increased ( P < 0.05) after AE+RE. The results suggest that the increased aerobic capacity shown with AE+RE was accompanied by a more robust increase in muscle size compared with RE. Although this response was not carried over to greater improvement in muscle function, it remains that intense AE can be executed prior to RE without compromising performance outcome.

scholarly journals Muscle quality index and isometric strength in older adults with hip osteoarthritis

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7471 ◽  
Author(s):  
Daniel Jerez-Mayorga ◽  
Luis Javier Chirosa Ríos ◽  
Alvaro Reyes ◽  
Pedro Delgado-Floody ◽  
Ramon Machado Payer ◽  
...  
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Quality Index ◽  
External Rotation ◽  
Hip Osteoarthritis ◽  
Peak Force ◽  
Isometric Strength ◽  
Muscle Quality ◽  
Stand Test ◽  
Sit To Stand

Background Older adults with hip osteoarthritis (OA) suffer a progressive loss of muscle quality and strength, affecting their daily activities and quality of life. The purpose of this study is to compare the levels of isometric strength among older adults with and without hip OA and healthy young adults, and to determine the relationship between muscle quality index (MQI) and isometric strength. Methods Fourteen subjects with hip OA (65.6 ± 3.0 years), 18 healthy older adults (66.6 ± 6.5 years) and 32 young adults (20.7 ± 2.0 years) participated in the study. MQI, isometric muscle strength of the hip, ten time sit-to-stand tests, and body composition were measured. Results The MQI was lower in subjects with hip OA, with no significant differences between groups (p > 0.054). Subjects with OA produced significantly less isometric strength in hip extension (p < 0.001), flexion (p < 0.001), abduction (p < 0.05), adduction (p < 0.001), external (p < 0.05) and internal rotation (p < 0.05). Subjects with OA demonstrated longer time in the execution of the sit-to-stand test (p < 0.001) in comparison with healthy older and young adults. High correlations between MQI, sit-to-stand (r =  − 0.76, p < 0.01) and peak force during hip abduction (r = 0.78, p < 0.01) where found in subjects with OA. Moderate correlation between MQI and peak force during hip flexion (r = 0.55, p < 0.05) and external rotation (r = 0.61, p < 0.05) were found in the OA group. Conclusions Subjects with OA have lower MQI than old and young healthy controls. In subjects with OA, there was a significant relationship between isometric strength of hip muscles and performance on the sit-to-stand test and the MQI.

Sign in / Sign up

Export Citation Format

Share Document