scholarly journals 1148Determinants of adherence to clinic appointments among Tuberculosis and HIV co-infected individuals, Johannesburg, South Africa

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Ruvimbo Nhandara ◽  
Birhanu Ayele ◽  
Lovelyn Ozougwu ◽  
Lovemore Sigwadhi ◽  
Peter Nyasulu

Abstract Background Tuberculosis (TB) is one of the leading cause of morbidity and mortality among people living with HIV/AIDS. The growing burden of TB/HIV co-infection continues to strain the healthcare system due to association with long duration of treatment. This is a catalyst for poor treatment adherence, which is a major public health challenge due to its propensity to drive drug resistance. This study evaluated the effects of treatment duration on adherence to treatment among TB/HIV co-infected patients. Method This was a cross sectional study that involved 10427 patients’ ≥18 years of age with HIV infection and co-infected with TB. We measure adherence to clinic appointments as ’good’ if ≥ 90% and poor if < 90%. We used multivariate logistic regression to evaluate factors associated with adherence to clinic appointments. Results 1528 patients were co-infected with TB, of these 17.4% of them attained good adherence to clinic appointments. Patients with TB/HIV co-infection who were on treatment for a longer period were less likely to adhere to clinic appointments (AOR: 0.98 95% CI: 0.97, 0.99). This confirms the notion that advanced disease has a negative impact on adherence to clinic attendance for follow up reviews. Conclusions Duration on treatment among TB/HIV co-infected patients is associated with treatment adherence. It is therefore vital to reinforce public health intervention that would enhance sustained treatment adherence and mitigate its impact on development of drug resistance.

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sophaphan Intahphuak ◽  
Tawatchai Apidechkul ◽  
Patita Kuipiaphum

Abstract Background Antibiotic resistance is often reported and great concerned as one of public health problems especially people living with poverty in developing countries including Thailand. The hill tribe people is defined as vulnerable population for antibiotic resistance in Thailand due to poor economic and education status particularly the Lahu people who is the second greatest group of the hill tribe people in Thailand. The study aimed to estimate the prevalence, factors associated with, and typing major species of bacteria with antibiotic drugs resistance among the Lahu hill tribe people in northern Thailand. Methods A cross-sectional study was conducted to gather the information from the participants. A validated questionnaire was used for data collection. Participants who presented an illness related to infectious diseases were eligible to participate the study and were asked to obtain specific specimen; sputum, urine or stool. Antibiotic susceptibility was tested by Kirbey Bauer’s disc diffusion test. Chi-square and logistic regression were used to detect the associations between variables at the significant level of α = 0.05. Results A total of 240 participants were recruited into the study. The majority had urinary tract infection (67.9%) with two major pathogenic species of the infection; Escherichia coli (12.8%), and Enterobacter cloacae (8.0%). The prevalence of antibiotic resistance was 16.0%. Escherichia coli and Klebsiella pneumoniae species were found to have multidrug resistance that was greater than that of other species, while ampicillin was found to have the greatest drug resistance. It was found that those who had poor knowledge of antibiotic use had a 2.56-fold greater chance (95% CI = 1.09–5.32) of having antibiotic resistance than did those who had good knowledge of antibiotic use, and those who had poor antibiotic use behaviors had a 1.79-fold greater chance (95% CI = 1.06–4.80) of having antibiotic resistance than did those who had good antibiotic use behaviors. Conclusion Effective public health interventions are urgently needed to reduce antibiotic drug resistance among the Lahu people by improving their knowledge and skills regarding the proper use of antibiotics and eventually minimizing antibiotic resistance. Moreover, health care professionals should strictly follow the standard guideline to prescribe antibiotics.


2020 ◽  
Author(s):  
SOPHAPHAN INTAHPHUAK ◽  
TAWATCHAI APIDECHKUL ◽  
PATITA KUIPIAPHUM

Abstract Background Antibiotic resistance is often reported and is of major concern as a public health problem. The hill tribe people in Thailand are considered populations vulnerable to antibiotic resistance due to their poor economic and educational status. The study aimed to estimate the prevalence of, the factors associated with, and the major species of bacteria involved in antibiotic drug resistance among the Lahu hill tribe people in northern Thailand. Methods A cross-sectional study was conducted to gather information from participants between March and September 2019. A validated questionnaire was used for data collection. Participants who presented an illness related to infectious diseases were eligible to participate in the study and were asked to obtain specific specimens. Antibiotic susceptibility was tested by the Kirbey-Bauer disk diffusion test. Chi-square tests and logistic regression were used to detect the associations between variables at the significance level of α = 0.05. Results A total of 240 participants were recruited into the study; 70.4% were females, 25.4% were aged 30–40 years. More than half worked in the agricultural sector (55.4%) and had an education level of less than primary school (45.8%). The majority had urinary tract infections (67.9%) with two major pathogenic species of the infection: Escherichia coli (12.8%) and Enterobacter cloacae (8.0%). The prevalence of antibiotic resistance was 16.0%. Escherichia coli and Klebsiella pneumoniae species were found to have multidrug resistance that was greater than that of other species, while ampicillin was found to have the greatest drug resistance. In the multivariate model, it was found that those who had poor knowledge of antibiotic use had a 2.56-fold greater chance (95% CI = 1.09–5.32) of having antibiotic resistance than did those who had good knowledge of antibiotic use, and those who had poor antibiotic use behaviors had a 1.79-fold greater chance (95% CI = 1.06–4.80) of having antibiotic resistance than did those who had good antibiotic use behaviors. Conclusion Effective public health interventions are urgently needed to reduce antibiotic drug resistance among the Lahu people by improving their knowledge and skills regarding the proper use of antibiotics and eventually minimizing antibiotic resistance.


2021 ◽  
Vol 9 ◽  
pp. 205031212110384
Author(s):  
Shewangizaw Hailemariam ◽  
Besufekad Mekonnen ◽  
Nigusie Shifera ◽  
Biruk Endalkachew ◽  
Molla Asnake ◽  
...  

Objective: Ethiopia is planning to vaccinate 20% of its population against the coronavirus disease 2019 pandemic by the end of 2021—however, there is no single piece of evidence regarding pregnant women’s intention to be vaccinated against coronavirus disease 2019; hence, the objective of this study was to investigate predicting factors of intention to be vaccinated against coronavirus disease 2019 among pregnant women in Bench-Sheko Zone, southwest Ethiopia. Methods: Facility-based cross-sectional study was undertaken from 1 February to 1 March 2021 in southwest Ethiopia. The study was carried out among pregnant women who came for antenatal care service in the selected public health facilities. Interviewer-administered structured tool was used to collect the data. Data were entered into EpiData (version 3.1) and then analyzed using SPSS (version 20). Results: The study revealed that only 31.3% (95% confidence interval: 26.7–35.2) of the participants had an intention to be vaccinated against coronavirus disease 2019 when the vaccine will be made available in Ethiopia. Participants’ intention to be vaccinated against coronavirus disease 2019 was significantly associated with attaining secondary school and above (adjusted odds ratio = 4.24, 95% confidence interval: 2.23–9.32), residing in urban areas (adjusted odds ratio = 2.57, 95% confidence interval: 1.22–5.40), being compliant with coronavirus disease 2019 guidelines (adjusted odds ratio = 5.86, 95% confidence interval: 3.40–10.09), and having good perception toward coronavirus disease 2019 vaccine (adjusted odds ratio = 3.04, 95% confidence interval: 1.64–5.62). Conclusion: Above all, in this study, pregnant women’s intention to vaccinate against coronavirus disease 2019 was very low when compared with previous studies. Hence, before commencing the coronavirus disease 2019 vaccination program in Ethiopia, it is essential to launch a widespread public health education campaign that could improve people’s perception of the vaccine. Besides, the upcoming public health intervention programs better put special emphasis on community members with lower educational attainment backgrounds and rural residents.


Author(s):  
Baliram Ghodke ◽  
Amit Mohite ◽  
Swapnil Shinkar

Background: AIDS mainly affects people aged 15-40 years. The co-infection of HIV/AIDS with other infectious diseases is an escalating public health problem. Public health intervention tools are effective only when knowledge needs are ably assessed. The objective of this study was to assess knowledge regarding HIV, routes of transmission, prevention and treatment in tribal students.Methods: Questionnaire was used to carry out this study in 120 tribal students enrolled in BA (bachelor of Arts) course in a college of tribal district of Maharashtra.Results: Out of 120 students, 104 students 86.67% completed the self-administered questionnaire. Out of 104 the 62.50% were males and 37.50% were females. 99.03% were aware of the word ‘HIV/AIDS’. 58.65% were aware of all possible routes of HIV transmission. Only 12.5% knew that unprotected anal sex carries high risk for HIV transmission.70.19% knew that HIV infection was not curable. 75% students said that weight loss was the major symptom of AIDS. 49.03% knew that tuberculosis was the principal opportunistic infection. 25% were aware of the ELISA test and 21.03% knew the location of treatment centre. The main sources of this information were television and the internet (72% and 71%).Conclusions: Tribal students have inadequate knowledge regarding routes of HIV transmission and its prevention. It is imperative to increase awareness by various channels of communications such as the mass media.


2020 ◽  
Vol 18 (5) ◽  
pp. 373-380 ◽  
Author(s):  
SeyedAhmad SeyedAlinaghi ◽  
Maryam Ghadimi ◽  
Mahboubeh Hajiabdolbaghi ◽  
Mehrnaz Rasoolinejad ◽  
Ladan Abbasian ◽  
...  

Background: COVID-19 has spread globally with remarkable speed, and currently, there is limited data available exploring any aspect of the intersection between HIV and SARSCoV- 2 co-infection. Objective: To estimate the prevalence of clinical symptoms associated with COVID-19 among people living with HIV (PLWH) in Tehran, Iran. Design: Cross-sectional study. Methods: A total of 200 PLWH were recruited through the positive club via sampling, and completed the symptom-based questionnaire for COVID-19, which was delivered by trained peers. Results: Of 200 participants, respiratory symptoms, including cough, sputum, and shortness of breath, were the most prevalent among participants, but only one person developed symptoms collectively suggested COVID-19 and sought treatments. Conclusions: It appears that existing infection with HIV or receiving antiretroviral treatment (ART) might reduce the susceptibility to the infection with SARS-CoV-2 or decrease the severity of the infection acquired. Further research is needed to understand causal mechanisms.


2020 ◽  
Vol 18 (6) ◽  
pp. 388-395
Author(s):  
Daniel Vargas-Pacherrez ◽  
Helma P. Cotrim ◽  
Leonardo Pires ◽  
Vitor Cunha ◽  
Vitor Coelho ◽  
...  

Introduction: The global prevalence of metabolic syndrome (MS) among people living with HIV/AIDS varies from 20% to 33%. Objective: to estimate the prevalence of metabolic syndrome and associated factors in a group of HIV-infected patients on antiretroviral therapy. Methods: This is a cross-sectional study with HIV-infected patients from a reference center in Bahia, Brazil. We evaluated clinical, socio-demographic and anthropometric data. MS was defined according to the guidelines of International Diabetes Federation. Results: We evaluated 152 patients with mean age of 47.3±11.6 years, 59.2% male. The main comorbidities detected were diabetes (3.3%) hypertriglyceridemia (9.3%) and metabolic syndrome (MS,38.2%). Patients with MS were predominantly women (55.2% vs 31.9%; p=0.005), older [52.1 (10.4) vs 44.3 (11.3); p<0.001], and had overweight (74.1% vs 23.4%; p<0.001). After multivariate analysis MS remained associated with age (OR = 1.076; 95% CI: 1.030 – 1.125), female sex (OR = 2.452; 95% CI: 1.114 – 5.374) and family history of hypertension (OR = 3.678; 95% CI: 1.431 – 9.395). Conclusion: Almost half of the HIV-infected patients in Bahia presents with MS which seems to be driven by classical risk factors.


2020 ◽  
Vol 15 (2) ◽  
pp. 105-110
Author(s):  
Haile Kassahun ◽  
Dugessa Tesfaye

Background: Disposal of pharmaceutical waste among patients is a global challenge especially in developing countries like Ethiopia. Improper medication disposal can lead to health problems and environmental contaminations. Therefore, the present study aimed to assess disposal practices of unused medications among patients in public health centers of Dessie town, Northeast Ethiopia. Methods: A descriptive cross-sectional study was conducted among 263 patients in four public health centers of Dessie town, Ethiopia from March to June, 2019. Face-to-face interviews using structured questionnaires were used to collect data from each study subject. Results: The majority of the respondents, 224 (85.17%) had unused medications at their home during the study period. The most commonly reported disposal method in the present study was flushing down into a toilet 66 (25.09%). None of the respondents practiced returning unused medications to Pharmacy. Moreover, 85 (32.31%) of the respondents reported never disposing their medications and believed that it is acceptable to store medications at home for future use. Conclusion: In the present study, there was a high practice of keeping medications at home and most of the disposal practices were not recommended methods. In addition, most of the respondents did not get advice from pharmacists and other health care professionals on how to dispose off unused medications. Hence, there is a need for proper education and guidance of patients regarding disposal practices of unused medications.


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