A Multinational Longitudinal Study Incorporating Intensive Methods to Examine Caregiver Experiences in the Context of Chronic Health Conditions: Protocol of the ENTWINE-iCohort

Informal caregivers are those who provide unpaid care to a relative or friend with a chronic illness, disability or other long-lasting health or care need. Providing informal care in the context of chronic health conditions presents a significant global challenge. Examination of the determinants of informal caregivers’ behaviour, especially in terms of motivations and willingness to provide/receive care, is crucial to understanding the nature of caregiver and care recipient experiences. A large group of international researchers have co-operated to execute the ENTWINE iCohort-a multinational, transdisciplinary, longitudinal study incorporating intensive methods to examine caregiver experiences in the context of chronic health conditions. The aim of ENTWINE-iCohort is to investigate the broad spectrum of factors, i.e., cultural, personal, geographical, relational, psychological, and economic that may affect motivations, willingness to provide or receive care, among diverse groups of informal caregivers and their care recipients, in different countries that have different care systems. Study questionnaires will be disseminated on-line in nine countries: Germany, Greece, Ireland, Italy, Israel, the Netherlands, Poland, Sweden, and the UK. Cross-sectional and longitudinal multivariate analysis, including intensive longitudinal and dyadic data analysis will be applied to examine the relative contribution of the above factors to caregiver or care recipient wellbeing.

Human Rights Advocacy Evaluation in the Global South: A Critical Review of the Literature

Advocacy evaluation has emerged in the past 20 years as a specialized area of evaluation practice. We offer a review of existing peer-reviewed literature and draw attention to the scarcity of scholarly work on human rights advocacy evaluation in the Global South. The lack of published material in this area is concerning, given the urgent need for human rights advocacy in the Global South and the difficulties of conducting advocacy in contexts in which fundamental human rights are often poorly protected. Based on the review of the literature and our professional experiences in human rights advocacy evaluation in the Global South, we identify themes in the literature that are especially salient in the Global South and warrant more attention. We also offer critical reflections on content areas not addressed in the existing literature and conclude with suggestions as to how activists, evaluators, and other stakeholders can contribute to the development of a field of practice that is responsive to the global challenge of advocacy evaluation.

A call for the library community to deploy best practices toward a database for biocultural knowledge relating to climate change

PurposeIn this paper, a call to the library and information science community to support documentation and conservation of cultural and biocultural heritage has been presentedDesign/methodology/approachBased in existing Literature, this proposal is generative and descriptive—rather than prescriptive—regarding precisely how libraries should collaborate to employ technical and ethical best practices to provide access to vital data, research and cultural narratives relating to climate.FindingsCOVID-19 and climate destruction signal urgent global challenges. Library best practices are positioned to respond to climate change. Literature indicates how libraries preserve, share and cross-link cultural and scientific knowledge. With wildfires, drought, flooding and other extreme or slow-onset weather events presenting dangers, it is imperative that libraries take joint action toward facilitating sustainable and open access to relevant information.Practical implicationsAn initiative could create an easily-accessible, open, linked, curated, secure and stakeholder-respectful database for global biocultural heritage—documenting traditional knowledge, local knowledge and climate adaptation traditions.Social implicationsOngoing stakeholder involvement from the outset should acknowledge preferences regarding whether or how much to share information. Ethical elements must be embedded from concept to granular access and metadata elements.Originality/valueRooted in the best practices and service orientation of library science, the proposal envisions a sustained response to a common global challenge. Stewardship would also broadly assist the global community by preserving and providing streamlined access to information of instrumental value to addressing climate change.

Climate change is raising sea levels in the oceans

Climate change is a global challenge, directly affecting ecosystems, environmental resources, and human life. One of its consequences is the problem of sea and ocean surface area, sea level is increasing day by day. In the long term, global mean sea level will continue to change continuously. The birth of the industrial revolution has made the Earth warmer and warmer, followed by many different causes leading to the rapid increase of global sea level: melting ice, expansion of the sea. water and changes in the Earth's climate system, costing the global economy trillions of dollars with many development consequences.

Use of a language intervention to reduce vaccine hesitancy

Vaccine hesitancy is a major global challenge facing COVID-19 immunization programs. Its main source is low public trust in the safety and effectiveness of the vaccine. In a preregistered experimental study, we investigated how using a foreign language when communicating COVID-19 vaccine information influences vaccine acceptance. Hong Kong Chinese residents (N = 611) received COVID-19 vaccine information either in their native Chinese or in English. English increased trust in the safety and effectiveness of the vaccine and, as a result, reduced vaccine hesitancy. This indicates that language can impact vaccine attitudes and demonstrate the potential of language interventions for a low cost, actionable strategy to curtail vaccine hesitancy amongst bilingual populations. Language interventions could contribute towards achieving the United Nations Sustainable Development Goal of health and well-being.

Two Birds with One Stone: Bioplastics and Food Waste Anaerobic Co-Digestion

Following the BBC’s Blue Planet II nature documentary series on marine ecosystems, plastic packaging has come under public fire, with consumers demanding greener alternatives. The biodegradable properties of some bioplastics have offered a potential solution to the global challenge of plastic pollution, while enabling the capture of food waste through anaerobic digestion as a circular and energy-positive waste treatment strategy. However, despite their increasing popularity, currently bioplastics are being tested in environments that do not reflect real-life waste management scenarios. Bioplastics find their most useful, meaningful and environmentally-sound application in food packaging—why is there so little interest in addressing their anaerobic co-digestion with food waste? Here, we provide a set of recommendations to ensure future studies on bioplastic end-of-life are fit for purpose. This perspective makes the link between the environmental sustainability of bioplastics and the role of food waste anaerobic digestion as we move towards an integrated food–energy–water–waste nexus. It shines light on a novel outlook in the field of bioplastic waste management while uncovering the complexity of a successful path forward. Ultimately, this research strives to ensure that the promotion of bioplastics within a circular economy framework is supported across waste collection and treatment stages.

Role of AmpC-Inducing Genes in Modulating Other Serine Beta-Lactamases in Escherichia coli

The consistently mutating bacterial genotypes appear to have accelerated the global challenge with antimicrobial resistance (AMR); it is therefore timely to investigate certain less-explored fields of targeting AMR mechanisms in bacterial pathogens. One of such areas is beta-lactamase (BLA) induction that can provide us with a collection of prospective therapeutic targets. The key genes (ampD, ampE and ampG) to which the AmpC induction mechanism is linked are also involved in regulating the production of fragmented muropeptides generated during cell-wall peptidoglycan recycling. Although the involvement of these genes in inducing class C BLAs is apparent, their effect on serine beta-lactamase (serine-BLA) induction is little known. Here, by using ∆ampD and ∆ampE mutants of E. coli, we attempted to elucidate the effects of ampD and ampE on the expression of serine-BLAs originating from Enterobacteriaceae, viz., CTX-M-15, TEM-1 and OXA-2. Results show that cefotaxime is the preferred inducer for CTX-M-15 and amoxicillin for TEM-1, whereas oxacillin for OXA-2. Surprisingly, exogenous BLA expressions are elevated in ∆ampD and ∆ampE mutants but do not always alter their beta-lactam susceptibility. Moreover, the beta-lactam resistance is increased upon in trans expression of ampD, whereas the same is decreased upon ampE expression, indicating a differential effect of ampD and ampE overexpression. In a nutshell, depending on the BLA, AmpD amidase moderately facilitates a varying level of serine-BLA expression whereas AmpE transporter acts likely as a negative regulator of serine-BLA.

Lower Rate of Daily Smokers With Symptomatic COVID-19: A Monocentric Self-Report of Smoking Habit Study

Background: Identification of prognostic factors in COVID-19 remains a global challenge. The role of smoking is still controversial.Methods: PCR-positive in- and outpatients with symptomatic COVID-19 from a large French University hospital were systematically interviewed for their smoking status, use of e-cigarette, and nicotinic substitutes. The rates of daily smokers in in- and outpatients were compared using the same smoking habit questionnaire to those in the 2019 French general population, after standardisation for sex and age.Results: The inpatient group was composed of 340 patients, median age of 66 years: 203 men (59.7%) and 137 women (40.3%), median age of both 66 years, with a rate of 4.1% daily smokers (CI 95% [2.3–6.9]) (5.4% of men and 2.2% of women). The outpatient group was composed of 139 patients, median age of 44 years: 62 men (44.6%, median age of 43 years) and 77 women (55.4%, median age of 44 years). The daily smoker rate was 6.1% (CI 95% [2.7–11.6], 5.1% of men and 6.8% of women). Amongst inpatients, daily smokers represented 2.2 and 3.4% of the 45 dead patients and of the 29 patients transferred to ICU, respectively. The rate of daily smokers was significantly lower in patients with symptomatic COVID-19, as compared to that in the French general population after standardisation by age and sex, with standardised incidence ratios (SIRs) of 0.24 [0.12–0.48] for outpatients and 0.24 [0.14–0.40] for inpatients.Conclusions: Daily smoker rate in patients with symptomatic COVID-19 is lower as compared to the French general population

From Local Concerns to Global Challenges: Continuity and Change in Sub-state “Green Nationalism”

Issues related to anthropogenic climate change such as global warming, fossil fuel emissions, and renewable energy have emerged as some of the most important and pertinent political questions today. While the role of the state in the Anthropocene has been explored in academia, there is a severe dearth of research on the relationship between climate change and nationalism, especially at the sub-state level. This paper builds on the concept of “green nationalism” among sub-state nationalist parties in European minority nations. Using a multimodal analysis of selected European Free Alliance (EFA) campaign posters from the past 30 years, the article explores an extensive “frame bridging” where minority nationalist political actors actively seek to link environmental issues to autonomy. Although there is an apparent continuity in minority nationalist support for green policies, earlier initiatives focused on preservation of local territory while EFA parties today frame climate change as a global challenge that requires local solutions, which only they can provide. The frame bridging between territorial belonging and progressive politics has lead to the emergence of an environmentally focused, minority nationalist agenda that advocates for autonomy in order to enact more ambitious green policies, or “green nationalism”. This shows that nationalism in the right ideological environment can be a foundation for climate action, as minority nationalist actors base their environmentally focused agenda to address the global climate crisis precisely on their nationalist ideology.