Human Immunodeficiency Virus (HIV)-Infected Human Blood Monocytes and Peritoneal Macrophages Have Reduced Anticryptococcal Activity whereas HIV-Infected Alveolar Macrophages Retain Normal Activity

1994 ◽  
Vol 170 (1) ◽  
pp. 60-67 ◽  
Author(s):  
M. L. Cameron ◽  
D. L. Granger ◽  
T. J. Matthews ◽  
J. B. Weinberg
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Blood ◽  
Alveolar Macrophages ◽  
Normal Activity ◽  
Peritoneal Macrophages ◽  
Blood Monocytes ◽  
Immunodeficiency Virus ◽  
Anticryptococcal Activity

scholarly journals Expression and Use of Human Immunodeficiency Virus Type 1 Coreceptors by Human Alveolar Macrophages

1999 ◽  
Vol 73 (7) ◽  
pp. 5865-5874 ◽  
Author(s):  
Stefan Worgall ◽  
Ruth Connor ◽  
Robert J. Kaner ◽  
Elizabeth Fenamore ◽  
Kristine Sheridan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Alveolar Macrophages ◽  
Chemokine Receptors ◽  
Productive Infection ◽  
Blood Monocytes ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) requires, in addition to CD4, coreceptors of the CC or CXC chemokine families for productive infection of T cells and cells of the monocyte-macrophage lineage. Based on the hypothesis that coreceptor expression on alveolar macrophages (AM) may influence HIV-1 infection of AM in the lung, this study analyzes the expression and utilization of HIV-1 coreceptors on AM of healthy individuals. AM were productively infected with five different primary isolates of HIV-1. Levels of surface expression of CCR5, CXCR4, and CD4 were low compared to those of blood monocytes, but CCR3 was not detectable. mRNA for CCR5, CXCR4, CCR2, and CCR3 were all detectable, but to varying degrees and with variability among donors. Expression of CCR5, CXCR4, and CCR2 mRNA was downregulated following stimulation with lipopolysaccharide (LPS). In contrast, secretion of the chemokines RANTES, MIP-1α, and MIP-1β was upregulated with LPS stimulation. Interestingly, HIV-1 replication was diminished following LPS stimulation. Infection of AM with HIV-1 in the presence of the CC chemokines demonstrated blocking of infection. Together, these studies demonstrate that AM can be infected by a variety of primary HIV-1 isolates, AM express a variety of chemokine receptors, the dominant coreceptor used for HIV entry into AM is CCR5, the expression of these receptors is dependent on the state of activation of AM, and the ability of HIV-1 to infect AM may be modulated by expression of the chemokine receptors and by chemokines per se.

scholarly journals Dendritic Cell Precursors Are Permissive to Dengue Virus and Human Immunodeficiency Virus Infection

2005 ◽  
Vol 79 (12) ◽  
pp. 7291-7299 ◽  
Author(s):  
Wing-Hong Kwan ◽  
Anna-Marija Helt ◽  
Concepción Marañón ◽  
Jean-Baptiste Barbaroux ◽  
Anne Hosmalin ◽  
...  
Keyword(s):  
Immune Response ◽  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Dengue Virus ◽  
Blood Monocytes ◽  
Dengue Virus Infection ◽  
Differentiation Potential ◽  
Antiviral Immune Response ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT CD14+ interstitial cells reside beneath the epidermis of skin and mucosal tissue and may therefore play an important role in viral infections and the shaping of an antiviral immune response. However, in contrast to dendritic cells (DC) or blood monocytes, these antigen-presenting cells (APC) have not been well studied. We have previously described long-lived CD14+ cells generated from CD34+ hematopoietic progenitors, which may represent model cells for interstitial CD14+ APC. Here, we show that these cells carry DC-SIGN and differentiate into immature DC in the presence of granulocyte-macrophage colony-stimulating factor. We have compared the CD14+ cells and the DC derived from these cells with respect to dengue virus and human immunodeficiency virus type 1 (HIV-1) infection. Both cell types are permissive to dengue virus infection, but the CD14+ cells secrete the anti-inflammatory cytokine interleukin 10 and no tumor necrosis factor alpha. Regarding HIV, the CD14+ cells are permissive to HIV-1, release higher p24 levels than the derived DC, and more efficiently activate HIV Pol-specific CD8+ memory T cells. The CD14+ DC precursors infected with either virus retain their DC differentiation potential. The results suggest that interstitial CD14+ APC may contribute to HIV-1 and dengue virus infection and the shaping of an antiviral immune response.

Inactivation and Partition of Human Immunodeficiency Virus during Kistler and Nitschmann Fractionation of Human Blood Plasma

Vox Sanguinis ◽  
1988 ◽  
Vol 54 (2) ◽  
pp. 78-83
Author(s):  
Y. Hénin ◽  
V. Maréchal ◽  
F. Barré-Sinoussi ◽  
J.-C. Chermann ◽  
J.-J. Morgenthaler
Keyword(s):  
Human Immunodeficiency Virus ◽  
Blood Plasma ◽  
Human Blood ◽  
Human Blood Plasma ◽  
Immunodeficiency Virus

scholarly journals Differential Effects of Interleukin-13 on Cytomegalovirus and Human Immunodeficiency Virus Infection in Human Alveolar Macrophages

Blood ◽  
1997 ◽  
Vol 89 (9) ◽  
pp. 3443-3450 ◽  
Author(s):  
William C. Hatch ◽  
Andrew R. Freedman ◽  
Deborah M. Boldt-Houle ◽  
Jerome E. Groopman ◽  
Ernest F. Terwilliger
Keyword(s):  
Human Immunodeficiency Virus ◽  
Alveolar Macrophages ◽  
Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Dependent Manner ◽  
Principal Line ◽  
Differential Effects ◽  
Interleukin 13 ◽  
Immunodeficiency Virus ◽  
Hiv 1

Abstract Alveolar macrophages, which form a principal line of defense against a variety of pulmonary pathogens, may themselves be infected by viruses like human immunodeficiency virus-1 (HIV-1), which impair their defensive functions. Interleukin-13 (IL-13), a multifunctional cytokine, has been considered for therapeutic use based on its potent inhibition of HIV-1 in these cells. We have further examined the effects of IL-13 on alveolar macrophages under conditions that reflect those seen in acquired immune deficiency syndrome, where this cell type is often infected by the opportunistic pathogen human cytomegalovirus (HCMV). Alveolar macrophages exposed to both HCMV and HIV-1 consistently exhibited higher levels of HIV-1 replication than cells exposed to HIV-1 alone. HIV-1 production was strongly suppressed in alveolar macrophages treated with IL-13 regardless of whether or not the cultures were coinfected with HCMV. However, IL-13 treatment markedly enhanced the expression of HCMV in otherwise latently infected macrophages in a dose dependent manner. These unexpected differential effects of IL-13 on host-virus interactions are important considerations in guiding its potential therapeutic applications.

Dyscoordinate Expression of Tumor Necrosis Factor-alpha by Human Blood Monocytes and Alveolar Macrophages

1989 ◽  
Vol 139 (4) ◽  
pp. 1010-1016 ◽  
Author(s):  
Elizabeth A. Rich ◽  
James R. Panuska ◽  
Robert S. Wallis ◽  
Christopher B. Wolf ◽  
Michelle L. Leonard ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Human Blood ◽  
Alveolar Macrophages ◽  
Tumor Necrosis ◽  
Blood Monocytes ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor
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