scholarly journals Biofoundries are a Nucleating Hub for Industrial Translation

2021 ◽  
Author(s):  
Tabasum Farzaneh ◽  
Paul S Freemont

Abstract Contemporary synthetic biology embraces the entire innovation pipeline; it’s a transformative technology platform impacting new applications and improving existing industrial products and processes. However, challenges still emerge at the interface of up-stream and down-stream processes, integral to the value chain. It is now clear that biofoundries have a key role to play in addressing this; they provide unique and accessible infrastructure to drive the standardization necessary to deliver systematic design and engineering of biological systems and workflows. As for other biofoundries, the success of the London Biofoundry has been in part due to its expertise in establishing channels for industrial translation through its extensive strategic collaborations. It has also become cemented as a key component of various consortia and partnerships that serve the broader bioeconomy and industrial strategies. Adopting a networked approach enables links to be made between infrastructure, researchers, industrialists and policy makers to de-risk the economic challenges of scale-up, as well as contribute to the growing bioeconomy.

Phycology ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 27-48
Author(s):  
Hazel A. Oxenford ◽  
Shelly-Ann Cox ◽  
Brigitta I. van Tussenbroek ◽  
Anne Desrochers

Over the last decade, the Caribbean has seen massive, episodic influxes of pelagic sargassum negatively impacting coastal ecosystems, people’s livelihoods and climate-sensitive sectors. Addressing this issue solely as a hazard has proven extremely costly and attention is slowly turning towards the potential opportunities for sargassum reuse and valorization. However, turning the ‘sargassum crisis into gold’ is not easy. In this study we use a multi-method approach to learn from sargassum stakeholders (researchers, entrepreneurs and established businesses) across the Caribbean about the constraints and challenges they are facing. These can be grouped into five broad categories: (1) unpredictable supply of sargassum; (2) issues related with the chemical composition of the seaweed; (3) harvest, transport and storage; (4) governance; and (5) funding. Specific issues and potential solutions associated with each of these categories are reviewed in detail and recommended actions are mapped to five entry points along a generalized value chain to demonstrate how these actions can contribute to the development of sustainable sargassum value chains that promote economic opportunities and could help alleviate impacts of massive influxes. This paper offers guidance to policy makers and funding agencies on existing gaps and challenges that need to be addressed in order to scale-up successful and sustainable solutions to the sargassum crisis.


Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2975
Author(s):  
Long Liu ◽  
Xinge Guo ◽  
Weixin Liu ◽  
Chengkuo Lee

With the fast development of energy harvesting technology, micro-nano or scale-up energy harvesters have been proposed to allow sensors or internet of things (IoT) applications with self-powered or self-sustained capabilities. Facilitation within smart homes, manipulators in industries and monitoring systems in natural settings are all moving toward intellectually adaptable and energy-saving advances by converting distributed energies across diverse situations. The updated developments of major applications powered by improved energy harvesters are highlighted in this review. To begin, we study the evolution of energy harvesting technologies from fundamentals to various materials. Secondly, self-powered sensors and self-sustained IoT applications are discussed regarding current strategies for energy harvesting and sensing. Third, subdivided classifications investigate typical and new applications for smart homes, gas sensing, human monitoring, robotics, transportation, blue energy, aircraft, and aerospace. Lastly, the prospects of smart cities in the 5G era are discussed and summarized, along with research and application directions that have emerged.


2022 ◽  
Vol 5 (1) ◽  
Author(s):  
Fengyu Zhang ◽  
Yanhong Sun ◽  
Yihao Zhang ◽  
Wenting Shen ◽  
Shujing Wang ◽  
...  

AbstractSynthetic Biology aims to create predictable biological circuits and fully operational biological systems. Although there are methods to create more stable oscillators, such as repressilators, independently controlling the oscillation of reporter genes in terms of their amplitude and period is only on theoretical level. Here, we introduce a new oscillator circuit that can be independently controlled by two inducers in Escherichia coli. Some control components, including σECF11 and NahR, were added to the circuit. By systematically tuning the concentration of the inducers, salicylate and IPTG, the amplitude and period can be modulated independently. Furthermore, we constructed a quantitative model to forecast the regulation results. Under the guidance of the model, the expected oscillation can be regulated by choosing the proper concentration combinations of inducers. In summary, our work achieved independent control of the oscillator circuit, which allows the oscillator to be modularized and used in more complex circuit designs.


2020 ◽  
Vol 110 (06) ◽  
pp. 363-367
Author(s):  
Tobias Kaufmann ◽  
Soumen Ganguly ◽  
Daniel Trauth ◽  
Wolfgang Maas ◽  
Thomas Bergs

Industrielle Güter durchlaufen eine Vielzahl von Bearbeitungsschritten, während der Bauteilwert sich entlang dieser Wertschöpfungskette steigert. Eine robuste und Edge-KI-basierte Vorhersage von Prozessergebnissen befähigt Maschinenbediener durch abgeleitete Handlungsempfehlungen aktiv bei ihrer Entscheidungsfindung. Dies ermöglicht nicht nur eine vorausschauend effiziente, sondern auch eine nachhaltige Produktion.   Industrial products pass through a multitude of processing steps, and their value is increased along this value chain. With a resilient and edge-ai-based prediction of process results, machine operators are significantly empowered in their decision-making process through recommendations for action. This enables not only a foresighted and efficient but also a sustainable production.


2017 ◽  
Vol 1 (3) ◽  
pp. 241-243
Author(s):  
Jeffrey Skolnick

As is typical of contemporary cutting-edge interdisciplinary fields, computational biology touches and impacts many disciplines ranging from fundamental studies in the areas of genomics, proteomics transcriptomics, lipidomics to practical applications such as personalized medicine, drug discovery, and synthetic biology. This editorial examines the multifaceted role computational biology plays. Using the tools of deep learning, it can make powerful predictions of many biological variables, which may not provide a deep understanding of what factors contribute to the phenomena. Alternatively, it can provide the how and the why of biological processes. Most importantly, it can help guide and interpret what experiments and biological systems to study.


2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Karen Lee ◽  
Femke van Nassau ◽  
Anne Grunseit ◽  
Kathleen Conte ◽  
Andrew Milat ◽  
...  

Abstract Background While known efficacious preventive health interventions exist, the current capacity to scale up these interventions is limited. In recent years, much attention has focussed on developing frameworks and methods for scale-up yet, in practice, the pathway for scale-up is seldom linear and may be highly dependent on contextual circumstances. Few studies have examined the process of scaling up from decision to implementation nor examined the sustainability of scaled-up interventions. This study explores decision-makers’ perceptions from real-world scaled-up case studies to examine how scale-up decisions were made and describe enablers of successful scale-up and sustainability. Methods This qualitative study included 29 interviews conducted with purposively sampled key Australian policy-makers, practitioners and researchers experienced in scale-up. Semi-structured interview questions obtained information regarding case studies of scaled-up interventions. The Framework Analysis method was used as the primary method of analysis of the interview data to inductively generate common and divergent themes within qualitative data across cases. Results A total of 31 case studies of public health interventions were described by interview respondents based on their experiences. According to the interviewees’ perceptions, decisions to scale up commonly occurred either opportunistically, when funding became available, or when a deliberate decision was made and funding allocated. The latter scenario was more common when the intervention aligned with specific political or strategic goals. Decisions to scale up were driven by a variety of key actors such as politicians, senior policy-makers and practitioners in the health system. Drivers of a successful scale-up process included good governance, clear leadership, and adequate resourcing and expertise. Establishing accountability structures and appropriate engagement mechanisms to encourage the uptake of interventions were also key enablers. Sustainability was influenced by evidence of impact as well as good acceptability among the general or target population. Conclusions Much like Kingdon’s Multiple Streams Theory of ‘policy windows’, there is a conceptually similar ‘window for scale-up’, driven by a complex interplay of factors such as political need, strategic context, funding and key actors. Researchers and policy-makers need to consider scalability from the outset and prepare for when the window for scale-up opens. Decision-makers need to provide longer term funding for scale-up to facilitate longer term sustainability and build on the resources already invested for the scale-up process.


2020 ◽  
Vol 11 (1) ◽  
pp. 23-31
Author(s):  
Maxwell S. DeNies ◽  
Allen P. Liu ◽  
Santiago Schnell

AbstractThe ability to construct a functional system from its individual components is foundational to understanding how it works. Synthetic biology is a broad field that draws from principles of engineering and computer science to create new biological systems or parts with novel function. While this has drawn well-deserved acclaim within the biotechnology community, application of synthetic biology methodologies to study biological systems has potential to fundamentally change how biomedical research is conducted by providing researchers with improved experimental control. While the concepts behind synthetic biology are not new, we present evidence supporting why the current research environment is conducive for integration of synthetic biology approaches within biomedical research. In this perspective we explore the idea of synthetic biology as a discovery science research tool and provide examples of both top-down and bottom-up approaches that have already been used to answer important physiology questions at both the organismal and molecular level.


Science ◽  
2011 ◽  
Vol 333 (6047) ◽  
pp. 1252-1254 ◽  
Author(s):  
Petra Schwille

How synthetic can “synthetic biology” be? A literal interpretation of the name of this new life science discipline invokes expectations of the systematic construction of biological systems with cells being built module by module—from the bottom up. But can this possibly be achieved, taking into account the enormous complexity and redundancy of living systems, which distinguish them quite remarkably from design features that characterize human inventions? There are several recent developments in biology, in tight conjunction with quantitative disciplines, that may bring this literal perspective into the realm of the possible. However, such bottom-up engineering requires tools that were originally designed by nature’s greatest tinkerer: evolution.


Author(s):  
Abdi Etafa Regassa

This paper analyzed the factors determining participation in irrigation project on agro pastoral household and their perception towards the scheme. The study result depends on cross-sectional data collected from a sample of 144 households of which 72 irrigation users and 72 non-users using a combination of multistage, stratified and random sampling. The data were analyzed using descriptive statistics and logistic regression to assess factors that affect participation in irrigation. Result revealed that agro pastoralists do have medium to very strong perception towards different aspects of irrigation performance indicator variable. It is observed that among the variables in logistic regression age, sex, income, input use and participation in cooperative organization have affected participation significantly and positively, while, farm experience, distance to the district market, and total livestock unit, affected participation in irrigation significantly and negatively. The study has also substantiated that irrigation in the study area has significant role on income and recommend that it shall be great and rewarding if policy makers, designers, implementers, and any funding agencies with similar interest. Further, capitalize and scale up the project to achieve the development plan and objective.Int. J. Agril. Res. Innov. & Tech. 5 (2): 44-50, December, 2015


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