Testosterone Stimulates Follicle-Stimulating Hormone β Transcription via Activation of Extracellular Signal-Regulated Kinase: Evidence in Rat Pituitary Cells1

2005 ◽  
Vol 72 (3) ◽  
pp. 523-529 ◽  
Author(s):  
D.J. Haisenleder ◽  
L.L. Burger ◽  
K.W. Aylor ◽  
A.C. Dalkin ◽  
H.E. Walsh ◽  
...  
Keyword(s):  
Follicle Stimulating Hormone ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Rat Pituitary ◽  
Stimulating Hormone

EFFECT OF TESTOSTERONE PROPIONATE ON THE RELEASE OF FSH FROM THE PITUITARY GLAND

1968 ◽  
Vol 57 (2) ◽  
pp. 289-295 ◽  
Author(s):  
E. Steinberger ◽  
G. Duckett
Keyword(s):  
Pituitary Gland ◽  
Leydig Cell ◽  
Testosterone Propionate ◽  
Follicle Stimulating Hormone ◽  
Inhibitory Effect ◽  
Blood Levels ◽  
Rat Pituitary ◽  
Pituitary Glands ◽  
Marked Drop ◽  
Stimulating Hormone

ABSTRACT On the basis of a study of changes in follicle stimulating hormone (FSH) levels in rat pituitary glands, obtained at various times after orchiectomy, it has been previously suggested that the Leydig cell secretions may regulate the release of FSH from the pituitary gland (Steinberger & Duckett 1966). This hypothesis was put to test in the present study. FSH levels have been determined in the pituitary gland and plasma of normal, testosterone-treated, orchiectomized, and orchiectomized testosteronetreated rats. A marked drop of pituitary FSH levels, associated with an elevation of plasma FSH levels, was observed in orchiectomized rats. Administration of testosterone to orchiectomized rats prevented the drop in pituitary FSH levels and rendered the blood levels undetectable. These results are interpreted as supporting the hypothesis that testosterone has an inhibitory effect on the release of FSH from the pituitary gland.

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