Increased Expression of Transforming Growth Factor-β1 and Thrombospondin-1 in Congenital Hepatic Fibrosis: Possible Role of the Hepatic Stellate Cell

1999 ◽  
Vol 28 (4) ◽  
pp. 386-392 ◽  
Author(s):  
Mounif El-Youssef ◽  
Yan Mu ◽  
Lijun Huang ◽  
Veronica Stellmach ◽  
Susan E. Crawford
Keyword(s):  
Growth Factor ◽  
Hepatic Fibrosis ◽  
Hepatic Stellate Cell ◽  
Transforming Growth Factor ◽  
Stellate Cell ◽  
Transforming Growth Factor Β1 ◽  
Congenital Hepatic Fibrosis ◽  
Thrombospondin 1

Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor-β1 toward Fibroblast-like Synovial Cells

2015 ◽  
Vol 42 (6) ◽  
pp. 943-947 ◽  
Author(s):  
Takahisa Suzuki ◽  
Naoki Iwamoto ◽  
Satoshi Yamasaki ◽  
Ayako Nishino ◽  
Yoshikazu Nakashima ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Disease Process ◽  
Transforming Growth Factor Β1 ◽  
Joint Disease ◽  
Synovial Cells ◽  
Thrombospondin 1 ◽  
Synovial Tissues ◽  
Tgf Β1

Objective.To investigate the role of thrombospondin 1 (TSP-1) in RA.Methods.Expression of TSP-1 in synovial tissues was determined by immunohistochemistry. Expression of TSP-1 in rheumatoid fibroblast-like synovial cells (FLS) was investigated by quantitative real-time PCR and ELISA. Correlations among the plasma TSP-1 and other variables in patients with RA were examined.Results.Expression of TSP-1 was increased in rheumatoid synovial tissues. Transforming growth factor-β1 (TGF-β1) clearly increased TSP-1 expression in FLS on both mRNA and protein levels. Changes in plasma TSP-1 were associated with those in 28-joint Disease Activity Score-erythrocyte sedimentation rate and plasma TGF-β1.Conclusion.TSP-1 might be critically involved in the disease process of RA through the TGF-β1/TSP-1 axis.

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