Clinical Significance of the Antinuclear Antibody Test in Selected Children with Idiopathic Thrombocytopenic Purpura

1997 ◽  
Vol 19 (4) ◽  
pp. 297-303 ◽  
Author(s):  
Sherri A. Zimmerman ◽  
Russell E. Ware
Keyword(s):  
Clinical Significance ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Antinuclear Antibody ◽  
Antibody Test ◽  
Thrombocytopenic Purpura

The Clinical Significance of the Antinuclear Antibody Test as a Screening Procedure for DNA Antibodies in SLE

1980 ◽  
Vol 25 (4) ◽  
pp. 293-298 ◽  
Author(s):  
A. E. El-Ghobarey ◽  
D. J. P. Sloane ◽  
K. Whaley
Keyword(s):  
Dna Binding ◽  
Clinical Significance ◽  
Antinuclear Antibody ◽  
Antibody Test ◽  
Diagnostic Value ◽  
Screening Procedure ◽  
Dna Antibodies ◽  
Screening Procedures

During the two-year period (1st October 1974–30th September 1976), 2979 sera were tested for DNA antibodies by the Farr test. One thousand six hundred and ninety-five of these were tested because they had high ANA titres (1/256 or greater). In this group 285 sera were found to have raised DNA binding capacities (DNA-bc), 86 of which were found in patients having diagnoses other than SLE. When the diagnoses were reviewed following the finding of a raised DNA-bc, 55 of these patients were found to be suffering from SLE. Of the 1284 sera tested for DNA antibodies without the prior ANA screening procedures, 288 were positive, 36 of which came from patients not considered to have SLE; 30 of these patients were subsequently shown to have SLE. Thus the DNA-bc test is an important tool in the diagnos is of SLE, and the ANA test appears to be a valuable screening procedure. The level of DNA-bc was not of any diagnostic value.

Prevalence of Autoantibodies Related to Some Autoimmune Disorders in Patients With Chronic Idiopathic Thrombocytopenic Purpura

2010 ◽  
Vol 17 (6) ◽  
pp. E114-E118 ◽  
Author(s):  
Cengiz Demir ◽  
Ramazan Esen ◽  
Murat Atmaca ◽  
Servet Efe
Keyword(s):  
Idiopathic Thrombocytopenic Purpura ◽  
Antinuclear Antibody ◽  
Tissue Transglutaminase ◽  
Clinical Importance ◽  
Healthy Controls ◽  
Chronic Idiopathic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura ◽  
Antibody Positivity ◽  
Long Term Impact

We investigated the prevalence of antinuclear antibody (ANA), thyroid antimicrosomal (AMA) and antithyroglobulin (ATA), antigliadin (AGA) immunoglobulin G (IgG)-A, anti-endomisium (EMA) IgG-A, and tissue transglutaminase (tTG) IgG-A in 87 patients with chronic idiopathic thrombocytopenic purpura (cITP) and in 95 healthy controls. Antinuclear antibody positivity was found in 13 of 87 patients and 3 of 95 controls ( P = .007). Antithyroglobulin positivity was found in 27 of patients and in 7 of the controls (P < .001). AMA positivity was found in 20 of patients and 8 of the controls (P = 0.008). Antigliadin IgG was positive in 17 patients and 1 controls (P < .001) whereas Antigliadin IgA was positive in 9 of patients and in 1 of the controls (P = .007). Anti-endomisium (IgG and IgA were not different between both groups. Tissue transglutaminase IgG was detected in 7 of patients and in 1 of the controls (P = .029). Tissue transglutaminase IgA was detected in 5 of patients and in none of the controls (P = .023). We believe that larger studies are needed to determine the long-term impact and clinical importance of these autoantibodies.

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