Comparison of psychological distress for breast, ovarian and colorectal cancer predisposition in a Spanish sample at high risk of hereditary cancer

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Gema Costa-Requena ◽  
Mercedes Garcia-Garijo ◽  
Paula Richart-Aznar ◽  
Ángel Segura-Huerta
Keyword(s):  
Colorectal Cancer ◽  
Psychological Distress ◽  
High Risk ◽  
Hereditary Cancer ◽  
Cancer Predisposition

Lack of GNAQ germline mutations in uveal melanoma patients with high risk for hereditary cancer predisposition

2010 ◽  
Vol 10 (2) ◽  
pp. 319-321 ◽  
Author(s):  
Mohamed H. Abdel-Rahman ◽  
Robert Pilarski ◽  
James B. Massengill ◽  
Benjamin B. Christopher ◽  
Frederick H. Davidorf
Keyword(s):  
High Risk ◽  
Uveal Melanoma ◽  
Hereditary Cancer ◽  
Germline Mutations ◽  
Cancer Predisposition ◽  
Melanoma Patients ◽  
Hereditary Cancer Predisposition

Melanoma candidate genes CDKN2A/p16/INK4A, p14ARF, and CDK4 sequencing in patients with uveal melanoma with relative high-risk for hereditary cancer predisposition

2011 ◽  
Vol 21 (3) ◽  
pp. 175-179 ◽  
Author(s):  
Mohamed H. Abdel-Rahman ◽  
Robert Pilarski ◽  
James B. Massengill ◽  
Benjamin N. Christopher ◽  
Ryan Noss ◽  
...  
Keyword(s):  
High Risk ◽  
Candidate Genes ◽  
Uveal Melanoma ◽  
Hereditary Cancer ◽  
Cancer Predisposition ◽  
P16 Ink4a ◽  
Hereditary Cancer Predisposition

scholarly journals Multigene Hereditary Cancer Panels Reveal High-Risk Pancreatic Cancer Susceptibility Genes

2018 ◽  
pp. 1-28 ◽  
Author(s):  
Chunling Hu ◽  
Holly LaDuca ◽  
Hermela Shimelis ◽  
Eric C. Polley ◽  
Jenna Lilyquist ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Family History ◽  
High Risk ◽  
Hereditary Cancer ◽  
Odds Ratio ◽  
Cancer Predisposition ◽  
Moderate Risk ◽  
Cancer Susceptibility Genes ◽  
Predisposition Genes ◽  
History Of

Purpose The relevance of inherited pathogenic mutations in cancer predisposition genes in pancreatic cancer is not well understood. We aimed to assess the characteristics of patients with pancreatic cancer referred for hereditary cancer genetic testing and to estimate the risk of pancreatic cancer associated with mutations in panel-based cancer predisposition genes in this high-risk population. Methods Patients with pancreatic cancer (N = 1,652) were identified from a 140,000-patient cohort undergoing multigene panel testing of predisposition genes between March 2012 and June 2016. Gene-level mutation frequencies relative to Exome Aggregation Consortium and Genome Aggregation Database reference controls were assessed. Results The frequency of germline cancer predisposition gene mutations among patients with pancreatic cancer was 20.73%. Mutations in ATM, BRCA2, CDKN2A, MSH2, MSH6, PALB2, and TP53 were associated with high pancreatic cancer risk (odds ratio, > 5), and mutations in BRCA1 were associated with moderate risk (odds ratio, > 2). In a logistic regression model adjusted for age at diagnosis and family history of cancer, ATM and BRCA2 mutations were associated with personal history of breast or pancreatic cancer, whereas PALB2 mutations were associated with family history of breast or pancreatic cancer. Conclusion These findings provide insight into the spectrum of mutations expected in patients with pancreatic cancer referred for cancer predisposition testing. Mutations in eight genes confer high or moderate risk of pancreatic cancer and may prove useful for risk assessment for pancreatic and other cancers. Family and personal histories of breast cancer are strong predictors of germline mutations.

Colorectal cancer knowledge and screening rates are lower than for breast cancer even in individuals at high risk of cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A741-A741
Author(s):  
P ANG ◽  
D SCHRAG ◽  
K SCHNEIDER ◽  
K SHANNON ◽  
J JOHNSON ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
High Risk ◽  
Cancer Knowledge ◽  
Risk Of Cancer

Comparison of Co-Presence of Epstein-Barr Virus and High-Risk Human Papillomaviruses in Colorectal Cancers in the Middle East Region

2020 ◽  
Author(s):  
Karim Nagi ◽  
Ishita Gupta ◽  
Hamda A Al-Thawadi ◽  
Ayesha Jabeen ◽  
Mohammed I. Malk ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Epstein Barr Virus ◽  
Human Papillomaviruses ◽  
Colorectal Cancers ◽  
Barr Virus ◽  
Human Carcinomas ◽  
Epstein Barr ◽  
Invasive Carcinomas ◽  
High Risk Hpv

Background: Several studies have shown the presence of onco viral DNA in colorectal tumor tissues. Viral infection by onco-viruses such as Human papillomaviruses (HPVs) and Epstein–Barr virus (EBV) are well-known to be involved in the onset and/or progression of numerous human carcinomas. Methods: We explored the co-presence of high-risk HPVs and EBV in a cohort of colorectal cancer samples from Lebanon (94) and Syria (102) by PCR, immunohistochemistry and tissue microarray. Results: The results of the study point out that 54% of colorectal cancer cases in Syria are positive for high-risk HPVs, while 30% of the cases in Lebanon are positive for these viruses; the most frequent high-risk HPV types in these populations are 16, 18, 31, 33 and 35. Analysis of LMP1 showed similar results in both populations; 36% of Syrian and 31% of Lebanese samples. Additionally, we report that EBV and high-risk HPVs are co-present in these samples. In Syrian samples, EBV and HPVs are co-present in 16% of the population, however, in the Lebanese samples, 20% of the cases are positive for both EBV and HPVs; their co-presence is associated with high/intermediate grade invasive carcinomas. Conclusion: These data suggest that EBV and high-risk HPVs are co-present in human colorectal cancers where they can cooperate in the progression of these cancers. Nevertheless, further studies are needed to elucidate the role of those oncoviruses in the development of human colorectal carcinomas.

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