An Evidence-based Approach to the Medical Management of Fibroids

2016 ◽  
Vol 59 (1) ◽  
pp. 30-52 ◽  
Author(s):  
CHANTAL B. BARTELS ◽  
KAMARIA C. CAYTON ◽  
FARAH S. CHUONG ◽  
KRISTINE HOLTHOUSER ◽  
SARA A. MEHR ◽  
...  
Keyword(s):  
Medical Management ◽  
Evidence Based

Abstract 1803: Catheterization without In-hospital Revascularization is Associated with Increased Long-term Mortality in Patients with Non-ST Elevation Myocardial Infarction and Significant Coronary Artery Disease

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Mark Y Chan ◽  
Kenneth W Mahaffey ◽  
Jie-Lena Sun ◽  
Karen S Pieper ◽  
Harvey D White ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Clinical Features ◽  
Medical Management ◽  
Significant Coronary Artery Disease ◽  
Evidence Based ◽  
St Elevation ◽  
Artery Disease

Background: Despite guidelines recommendations for early invasive management in non-ST-elevation myocardial infarction (NSTEMI), some patients (pts) with significant coronary artery disease (CAD) found on early angiography do not undergo revascularization. The prevalence, clinical features, and long-term prognosis of this population have not been well-characterized. Methods: We evaluated 8225 NSTEMI pts from the SYNERGY trial (2002–2004) with >50% stenosis in at least 1 epicardial artery who received in-hospital percutaneous coronary intervention (PCI), in-hospital coronary artery bypass grafting (CABG), or no revascularization before discharge (medical management). A propensity-adjusted Cox proportional hazards model was used to compare death/MI rates at 6 months and mortality rates at 1 year among the 3 subgroups starting from the time of hospital discharge. Results: A total of 2633 of 8255 pts (32%) were medically managed, 4294 (52%) underwent PCI, and 1298 (16%) underwent CABG. Clinical features and unadjusted outcomes are shown below. Guidelines-recommended discharge medications were used in a large proportion of patients, but those undergoing PCI most commonly received evidence-based therapies. The adjusted risk of 6-month death or MI was 2.19 (95% CI: 1.79–2.67) for medical management compared with PCI, and 3.07 (95% CI: 2.18 – 4.34) for medical management compared with CABG. The adjusted risks of 1-year mortality for medical management were 1.52 (95% CI: 1.07–2.17) and 1.70 (95% CI: 0.96–3.03), respectively. Conclusion: A substantial proportion of NSTEMI pts with significant CAD are managed medically without in-hospital revascularization. These pts have higher-risk clinical characteristics and worse outcomes compared with those who undergo PCI or CABG, despite fairly good use of evidence-based medications. Therefore, innovative treatment strategies are needed to mitigate the increased risk of adverse outcomes in this population. Baseline Characteristics, Discharge Medications, and Unadjusted Clinical Outcomes for the 3 Groups

scholarly journals 3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn’s Disease 2016: Part 1: Diagnosis and Medical Management

2016 ◽  
Vol 11 (1) ◽  
pp. 3-25 ◽  
Author(s):  
Fernando Gomollón ◽  
Axel Dignass ◽  
Vito Annese ◽  
Herbert Tilg ◽  
Gert Van Assche ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Medical Management ◽  
Evidence Based ◽  
Diagnosis And Management

Medical management of urolithiasis in the Middle Ages: Thesaurus Pauperum of Pope John XXI

2019 ◽  
Vol 87 (2) ◽  
pp. 75-79
Author(s):  
Daniele Castellani ◽  
Michele Pucci ◽  
Cristian Cicconetti ◽  
Maria Pia Pavia ◽  
Marco Dellabella
Keyword(s):  
Middle Ages ◽  
Medical Management ◽  
Comprehensive Analysis ◽  
Evidence Based ◽  
Ordinary People ◽  
Review Of The Literature ◽  
Medical Book ◽  
The University ◽  
Based Medicine ◽  
The Middle Ages

Background/Objective: This paper will present a brief description of medicine in the Middle Ages, and more comprehensive analysis of the medical management of urolithiasis in Thesaurus Pauperum, the main text of Pedro Hispano. Method: An in-depth reading of the Italian translation of Thesaurus Pauperum, and a review of the literature of the life of Pedro Rebuli Guiliani, known as Pedro Hispano, was performed. Result: Pedro Hispano was born in Portugal around 1205. He studied philosophy, theology and medicine in Paris. He was named professor of medicine at the University of Siena in 1247 and was elected Pope, as John XXI, in 1276. His primary medical book was Thesaurus Pauperum (‘Treasure of the Poor’), a prescription handbook for common diseases, directed not only to physicians but also to ordinary people. We focused on the description of medical management of urolithiasis in Thesaurus Pauperum. Conclusion: This text is interesting not so much on account of the pharmacopoeia used, but instead, because it is, probably, one of the first medical text reporting therapeutics close to the modern evidence-based medicine.

scholarly journals Evidence-Based Medical Management of Peripheral Artery Disease

2020 ◽  
Vol 40 (3) ◽  
pp. 541-553 ◽  
Author(s):  
Graham H. Bevan ◽  
Khendi T. White Solaru
Keyword(s):  
Peripheral Artery Disease ◽  
Medical Management ◽  
Limb Ischemia ◽  
Evidence Based ◽  
Cholesterol Reduction ◽  
Pressure Management ◽  
Peripheral Artery ◽  
Lifestyle Modifications ◽  
Systemic Complications ◽  
Artery Disease

Peripheral artery disease is an atherosclerotic disease of the lower extremities associated with high cardiovascular mortality. Management of this condition may include lifestyle modifications, medical management, endovascular repair, or surgery. The medical approach to peripheral artery disease is multifaceted and includes cholesterol reduction, antiplatelet therapy, anticoagulation, peripheral vasodilators, blood pressure management, exercise therapy, and smoking cessation. Adherence to this regimen can reduce limb-related complications like critical limb ischemia and amputation, as well as systemic complications of atherosclerosis like stroke and myocardial infarction. Relative to coronary artery disease, peripheral artery disease is an undertreated condition. In this article, we explore the evidence behind medical therapies for the management of peripheral artery disease.

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