Storing CO2 in geological formations is an important component of reducing greenhouse gases emissions. The Carbon Capture and Storage (CCS) industry is now in its establishing phase, and if successful, massive storage volumes would be needed. It will hence be important to utilize each storage site to its maximum, without challenging the formation integrity. For different reasons, supply of CO2 to the injection sites may be periodical or unstable, often considered as a risk element reducing the overall efficiency and economics of CCS projects. In this paper we present outcomes of investigations focusing on a variety of positive aspects of periodic CO2 injection, including pressure management and storage capacity, also highlighting reservoir monitoring opportunities. A feasibility study of periodic injection into an infinite saline aquifer using a mechanistic reservoir model has indicated significant improvement in storage capacity compared to continuous injection. The reservoir pressure and CO2 plume behavior were further studied revealing a ‘CO2 expansion squeeze’ effect that governs the improved storage capacity observed in the feasibility study. Finally, the improved pressure measurement and storage capacity by periodic injection was confirmed by field-scale simulations based on a real geological set-up. The field-scale simulations have confirmed that ‘CO2 expansion squeeze’ governs the positive effect, which is also influenced by well location in the geological structure and aquifer size, while CO2 dissolution in water showed minor influence. Additional reservoir effects and risks not covered in this paper are then highlighted as a scope for further studies. The value of the periodic injection with intermittent CO2 supply is finally discussed in the context of deployment and integration of this technology in the establishing CCS industry.