Altered matrix metalloproteinase 9 and tissue inhibitor of metalloproteinases 1 levels in children with primary hypertension

2016 ◽  
Vol 34 (9) ◽  
pp. 1815-1822 ◽  
Author(s):  
Anna Niemirska ◽  
Mieczysław Litwin ◽  
Joanna Trojanek ◽  
Lidia Gackowska ◽  
Izabela Kubiszewska ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Primary Hypertension ◽  
Tissue Inhibitor Of Metalloproteinases ◽  
Tissue Inhibitor ◽  
Metalloproteinase 9

scholarly journals Levels of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 mRNAs in Patients with Primary Hypertension or Hypertension-Induced Atherosclerosis

2012 ◽  
Vol 40 (3) ◽  
pp. 986-994 ◽  
Author(s):  
W Su ◽  
F Gao ◽  
J Lu ◽  
W Wu ◽  
G Zhou ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Atherosclerotic Plaque ◽  
Matrix Metalloproteinase 9 ◽  
Primary Hypertension ◽  
Mrna Levels ◽  
Tissue Inhibitor ◽  
Hypertensive Patients ◽  
Matrix Metalloproteinase 1 ◽  
Normotensive Subjects ◽  
Metalloproteinase 9

OBJECTIVE: Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) affect degradation of vascular elastin, collagen remodelling and formation of atherosclerotic plaque. This cross-sectional study investigated the levels of MMP-9 and TIMP-1 mRNAs in the blood of patients with primary hypertension with and without hypertension-induced carotid atherosclerosis. METHODS: Hypertensive patients with and without atherosclerosis and age- and gender-matched normotensive subjects were enrolled. MMP-9 and TIMP-1 mRNA were quantified using real-time reverse transcription—polymerase chain reaction. RESULTS: Hypertensive patients ( n = 86) had significantly lower levels of TIMP-1 mRNA than normotensive subjects ( n = 43). Hypertensive patients with atherosclerosis ( n = 42) showed significantly elevated levels of MMP-9 mRNA compared with both normotensive subjects and hypertensive patients without atherosclerosis ( n = 44). CONCLUSIONS: Primary hypertension resulted in decreased TIMP-1 mRNA levels, suggesting a potential mechanism contributing to the degradation of elastin. Hypertension-induced atherosclerosis was associated with significantly increased levels of MMP-9 mRNA, which may enhance both the deposition of types I and III collagen and atherosclerotic plaque formation.

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