scholarly journals The Imbalance between Matrix Metalloproteinase-9, -2 and Tissue Inhibitor of Metalloproteinases-1 in Acute Phase Kawasaki Disease

2003 ◽  
Vol 53 (1) ◽  
pp. 170-170 ◽  
Author(s):  
Kyoko Sekiguchi ◽  
Takashi Ishikita ◽  
Kuriko Nakamura ◽  
Hiroshi Hoshida ◽  
Tomotaka Nakayama ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Matrix Metalloproteinase ◽  
Acute Phase ◽  
Matrix Metalloproteinase 9 ◽  
Tissue Inhibitor Of Metalloproteinases ◽  
Tissue Inhibitor ◽  
Metalloproteinase 9

scholarly journals Elevated Levels of Matrix Metalloproteinase 9 and Tissue Inhibitor of Metalloproteinase 1 during the Acute Phase of Kawasaki Disease

2003 ◽  
Vol 10 (2) ◽  
pp. 308-314 ◽  
Author(s):  
Pong Kian Chua ◽  
Marian E. Melish ◽  
Qigui Yu ◽  
Richard Yanagihara ◽  
Kara S. Yamamoto ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Matrix Metalloproteinase ◽  
Acute Phase ◽  
Matrix Metalloproteinase 9 ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Unknown Etiology ◽  
Tissue Inhibitor ◽  
Protein Levels ◽  
Aneurysm Formation ◽  
Metalloproteinase 9

ABSTRACT Kawasaki disease (KD) is an acute, self-limiting, multisystem vasculitis of unknown etiology affecting infants and young children. Unless treated promptly with high-dose intravenous gamma globulin and aspirin, patients frequently develop coronary aneurysms. Previously, matrix metalloproteinase 9 (MMP-9), which is secreted complexed to tissue inhibitor of metalloproteinase 1 (TIMP-1), has been implicated in abdominal aortic aneurysm formation. Since the clinical and pathological features of KD include inflammation and weakening of blood vessels, we analyzed acute- and convalescent-phase paired plasma or serum samples from 31 KD patients, 7 patients who did not completely meet the criteria for KD, and 26 non-KD controls (9 febrile and 17 afebrile patients) for pro-MMP-9 (92 kDa) enzyme activity by gelatin zymography and for active MMP-9 (83 kDa), pro-MMP-9, and TIMP-1 protein levels by enzyme-linked immunosorbent assay. Statistical analysis was performed by using Student t tests, linear regression, and the Wilcoxon rank-sum test. Markedly elevated pro-MMP-9 enzymatic activity, pro-MMP-9 protein levels, and TIMP-1 protein levels were found during the acute phase of illness in patients with clinically established KD and in patients who were suspected of having KD but did not meet all of the criteria. There was no significant difference in active MMP-9 levels. Furthermore, pro-MMP-9 and TIMP-1 protein levels were significantly elevated among KD patients, compared to those of febrile and afebrile non-KD controls. The significantly elevated pro-MMP-9 enzyme and protein levels during the acute phase of KD may reflect vascular remodeling or an inflammatory response to a microbial agent, suggesting a pathophysiological role for MMP-9 in coronary aneurysm formation.

Altered matrix metalloproteinase 9 and tissue inhibitor of metalloproteinases 1 levels in children with primary hypertension

2016 ◽  
Vol 34 (9) ◽  
pp. 1815-1822 ◽  
Author(s):  
Anna Niemirska ◽  
Mieczysław Litwin ◽  
Joanna Trojanek ◽  
Lidia Gackowska ◽  
Izabela Kubiszewska ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Primary Hypertension ◽  
Tissue Inhibitor Of Metalloproteinases ◽  
Tissue Inhibitor ◽  
Metalloproteinase 9
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