Abstract
Background: Hypothyroidism in pregnancy is known to be associated with adverse outcomes depending on geographical distribution and diagnostic criteria. We analyze the maternal factors affecting pregnancy outcomes in maternal hypothyroidism for the first time in Pakistan.Methods: We conducted a retrospective study on pregnant women attending obstetric clinics during the year 2008-2016. We noted maternal factors such as maternal age, gestational age at antenatal visit, gestational diabetes mellitus, hypertension, and past obstetric history of miscarriages affecting pregnancy loss or live birth in pregnant hypothyroid women as well as normal healthy pregnant women. Odds ratio was calculated using multivariate logistic regression. Subgroup analysis was carried out to compare women with overt versus subclinical hypothyroidism. All data analysis was performed on Stata version 12.Results: Maternal age, gestational age at antenatal visit, gestational diabetes mellitus, hypertension, and past obstetric history of miscarriages were significantly associated with the outcome at the univariate analysis. At multivariable analysis, maternal age, gestational age at the antenatal visit, and past obstetric history of miscarriages were associated with an increased likelihood of pregnancy loss, whereas, gestational diabetes mellitus and hypothyroidism were found to be counter-protective. Subgroup analysis revealed no difference between women those with overt versus subclinical hypothyroidism.Conclusion: We report maternal factors such as age, gestational age at the antenatal visit, and past obstetric history of miscarriages as significant factors affecting adverse pregnancy outcomes in hypothyroidism for the first time from Pakistan.
Successful Pregnancy Outcome in Unicornuate Uterus