Plasma and Platelet Transfusion Strategies in Critically Ill Children Following Severe Trauma, Traumatic Brain Injury, and/or Intracranial Hemorrhage: From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding

2022 ◽  
Vol 23 (Supplement 1 1S) ◽  
pp. e14-e24 ◽  
Author(s):  
Robert Russell ◽  
David F. Bauer ◽  
Susan M. Goobie ◽  
Thorsten Haas ◽  
Marianne E. Nellis ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Critically Ill ◽  
Intracranial Hemorrhage ◽  
Platelet Transfusion ◽  
Severe Trauma ◽  
Critically Ill Children

scholarly journals Early hyperoxemia is associated with lower adjusted mortality after severe trauma: results from a French registry

Critical Care ◽  
2020 ◽  
Vol 24 (1) ◽  
Author(s):  
Josefine S. Baekgaard ◽  
◽  
Paer-Selim Abback ◽  
Marouane Boubaya ◽  
Jean-Denis Moyer ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Propensity Score ◽  
Hospital Mortality ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Univariate Analysis ◽  
Severe Trauma ◽  
Arterial Oxygen ◽  
Trauma Patients

Abstract Background Hyperoxemia has been associated with increased mortality in critically ill patients, but little is known about its effect in trauma patients. The objective of this study was to assess the association between early hyperoxemia and in-hospital mortality after severe trauma. We hypothesized that a PaO2 ≥ 150 mmHg on admission was associated with increased in-hospital mortality. Methods Using data issued from a multicenter prospective trauma registry in France, we included trauma patients managed by the emergency medical services between May 2016 and March 2019 and admitted to a level I trauma center. Early hyperoxemia was defined as an arterial oxygen tension (PaO2) above 150 mmHg measured on hospital admission. In-hospital mortality was compared between normoxemic (150 > PaO2 ≥ 60 mmHg) and hyperoxemic patients using a propensity-score model with predetermined variables (gender, age, prehospital heart rate and systolic blood pressure, temperature, hemoglobin and arterial lactate, use of mechanical ventilation, presence of traumatic brain injury (TBI), initial Glasgow Coma Scale score, Injury Severity Score (ISS), American Society of Anesthesiologists physical health class > I, and presence of hemorrhagic shock). Results A total of 5912 patients were analyzed. The median age was 39 [26–55] years and 78% were male. More than half (53%) of the patients had an ISS above 15, and 32% had traumatic brain injury. On univariate analysis, the in-hospital mortality was higher in hyperoxemic patients compared to normoxemic patients (12% versus 9%, p < 0.0001). However, after propensity score matching, we found a significantly lower in-hospital mortality in hyperoxemic patients compared to normoxemic patients (OR 0.59 [0.50–0.70], p < 0.0001). Conclusion In this large observational study, early hyperoxemia in trauma patients was associated with reduced adjusted in-hospital mortality. This result contrasts the unadjusted in-hospital mortality as well as numerous other findings reported in acutely and critically ill patients. The study calls for a randomized clinical trial to further investigate this association.

Management of critically ill children with traumatic brain injury

2008 ◽  
Vol 18 (6) ◽  
pp. 455-461 ◽  
Author(s):  
GILLES A. ORLIAGUET ◽  
PHILIPPE G. MEYER ◽  
THOMAS BAUGNON
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Critically Ill ◽  
Critically Ill Children

Serum Biomarkers Help Predict Attention Problems in Critically Ill Children With Traumatic Brain Injury

2016 ◽  
Vol 17 (7) ◽  
pp. 638-648 ◽  
Author(s):  
Amy A. Wilkinson ◽  
Nevena Simic ◽  
Helena Frndova ◽  
Margot J. Taylor ◽  
Karen Choong ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Critically Ill ◽  
Attention Problems ◽  
Serum Biomarkers ◽  
Critically Ill Children

scholarly journals Evaluation of development of diabetes insipidus in the early phase following traumatic brain injury in critically ill patients

Critical Care ◽  
2008 ◽  
Vol 12 (Suppl 2) ◽  
pp. P130 ◽  
Author(s):  
V Karali ◽  
E Massa ◽  
G Vassiliadou ◽  
I Chouris ◽  
I Rodin ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Diabetes Insipidus ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Early Phase
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