Revised Nodal Staging Integrating Tumor Deposit Counts With Positive Lymph Nodes in Patients With Stage III Colon Cancer

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Dae Hee Pyo ◽  
Seok Hyung Kim ◽  
Sang Yoon Ha ◽  
Seong Hyeon Yun ◽  
Yong Beom Cho ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Stage Iii ◽  
Nodal Staging ◽  
Stage Iii Colon Cancer ◽  
Tumor Deposit ◽  
Positive Lymph Nodes

The Prognostic Superiority of Log Odds of Positive Lymph Nodes in Stage III Colon Cancer

2008 ◽  
Vol 12 (10) ◽  
pp. 1790-1796 ◽  
Author(s):  
Jiping Wang ◽  
James M. Hassett ◽  
Merril T. Dayton ◽  
Mahmoud N. Kulaylat
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
Log Odds ◽  
Positive Lymph Nodes

Should Total Number of Lymph Nodes be Used as a Quality of Care Measure for Stage III Colon Cancer?

2010 ◽  
Vol 251 (1) ◽  
pp. 184-185
Author(s):  
Jiping Wang ◽  
Mahmoud Kulaylat ◽  
James Hassett ◽  
Kelli Bullard Dunn ◽  
Merril Dayton ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Quality Of Care ◽  
Lymph Nodes ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
Care Measure

The role of early postoperative PET-CT in patients with pathological stage III colon cancer: Results from a large single institution study.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 562-562
Author(s):  
Assaf Moore ◽  
Irit Ben-Aharon ◽  
Ofer Purim ◽  
Gali Perl ◽  
Olga Ulitsky ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Metastatic Disease ◽  
Stage Iii ◽  
Individual Risk ◽  
Pathological Stage ◽  
Stage Iii Colon Cancer ◽  
Pet Ct

562 Background: Current staging of patients (pts) with pathological stage III colon cancer is suboptimal; many pts still recur despite unremarkable preoperative staging work-up. We previously reported that early postoperative PET-CT can alter the stage and management of pts with high risk stage III colon cancer in up to 19% of patients. The aim of the current study was to expand the previous one to a larger cohort and to determine the role of early postoperative PET-CT in the general population of stage III colon cancer pts, regardless of their individual risk. Methods: A retrospective chart review of all consecutive pts with stage III colon cancer who underwent early postoperative PET-CT between 2007 and 2016. Demographic and clinicopathological data were collected. Results: 247 pts, 124 (50%) males, with a median age of 66 years (range, 30-92), were included. Pathological stage was IIIA, IIIB and IIIC in 18 (7.3%), 161 (65.1%) and 72 (29.1%) pts, respectively. The median number of lymph nodes retrieved was 15 (range, 6-64) and that of positive lymph nodes was 2 (range, 0-21). High FDG-uptake was observed in 52 (21.0%) pts, including 6 (2.4%) who had clear postoperative changes, 10 (4.0%) who had a false positive abnormal uptake of whom 6 underwent invasive diagnostic procedures. The PET-CT results modified the management of 36 pts (14.5%) who were found to have true positive findings: 30 (12.1%) were proven to have overt metastatic disease and in 6 (2.4%) a second primary was discovered. With the median follow-up of 39.0 months (range 7.2-98.4 months), of the 30 pts found to be metastatic, 10 (33.3%) underwent curative treatments and are currently with no evidence of disease (NED). Updated data, on more patients and a longer follow-up, will be presented at the meeting. Conclusions: Early postoperative PET-CT changed the staging and treatment of 14.5% of resected stage III pts, and has the potential for early detection of curable metastatic disease. We currently evaluate this strategy and its actual impact in a prospective trial.

Should Total Number of Lymph Nodes be Used as a Quality of Care Measure for Stage III Colon Cancer?

2009 ◽  
Vol 249 (4) ◽  
pp. 559-563 ◽  
Author(s):  
Jiping Wang ◽  
Mahmoud Kulaylat ◽  
Howard Rockette ◽  
James Hassett ◽  
Ashwani Rajput ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Quality Of Care ◽  
Lymph Nodes ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
Care Measure

Microsatellite instability and retrieval of lymph nodes in stage III colon cancer: harbinger or hermit?—reply

2012 ◽  
Vol 43 (10) ◽  
pp. 1786
Author(s):  
Erin MacQuarrie ◽  
Thomas Arnason ◽  
Jennette Gruchy ◽  
Sen Yan ◽  
Arik Drucker ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Microsatellite Instability ◽  
Stage Iii ◽  
Stage Iii Colon Cancer

Relation between the size of nonmetastatic and metastatic lymph nodes and outcomes in patients with stage III colon cancer.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 494-494
Author(s):  
Kazutake Okada ◽  
Sotaro Sadahiro ◽  
Yutaro Kamei ◽  
Takashi Ogimi ◽  
Hiroshi Miyakita ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Prognostic Factor ◽  
Lymph Nodes ◽  
Tumor Size ◽  
Venous Invasion ◽  
Stage Iii ◽  
Receiver Operating Characteristic Curves ◽  
Stage Iii Colon Cancer ◽  
Lymph Node Size ◽  
Cell Components

494 Background: In colon cancer, retrieval of less than 12 lymph nodes is a risk factor for recurrence. We previously reported that the long-axis diameter of the largest LNs (maximum LNs) is associated with a higher number of retrieved LNs and better outcomes in stage II disease (Int J Colorectal Dis 2015). Furthermore, the number of natural killer cells in the maximum LNs is associated with the number of retrieved LNs and lymph node size, and is an independent prognostic factor (Oncology 2018). We examined whether the long-axis diameter of maximum LNs with and without metastasis is a prognostic factor in stage III colon cancer. Methods: The study group comprised 190 patients with stage III colon cancer from 2005 to 2014. For each patient, one negative LN and one positive LN with the greatest long-axis diameter were selected, and the diameter was measured on H-E stained specimens. The endpoint of survival analysis was relapse free survival (RFS). The cut-off value (COV) was determined by using receiver operating characteristic curves. Results: The mean long-axis diameter of maximum negative and positive LNs were 8.5 ± 3.7 and 9.9 ± 4.9 mm, respectively. Factors related to the number of retrieved LNs were the tumor size (less than 4.3 cm, 13.5 ± 6.4; 4.3 cm or more, 16.6 ± 7.3; p = 0.004) and the long axis diameter of maximum negative LNs (< 8.1 mm, 13.4 ± 6.9; ≥ 8.1 mm, 17.6 ± 6.6; p < 0.001). Maximum negative LNs with a diameter of ≥ 8.1 mm was associated with significantly better RFS than maximum negative LNs with a diameter of < 8.1 mm (p = 0.020). The diameter of maximum positive LNs was not a prognostic factor. On multivariate analysis, the tumor size (≥ 4.3 cm/< 4.3 cm, HR 3.02; p < 0.001), venous invasion (absent/present, HR 0.41; p = 0.017), the number of LNs (≥ 12/< 12, HR 0.56; p = 0.043), and the diameter of maximum negative LNs (≥ 8.1 mm/< 8.1 mm, HR 0.45; p = 0.008) were independent prognostic factors. Conclusions: In stage III colon cancer, the long-axis diameter of negative maximum LNs was a prognostic factor. Enlarged negative LNs are caused by hyperplasia of cell components in LNs. The size of negative maximum LNs might reflect the tumor immunity of the host.

scholarly journals A Lymph Node Ratio of 10% Is Predictive of Survival in Stage III Colon Cancer: A French Regional Study

2014 ◽  
Vol 99 (4) ◽  
pp. 344-353 ◽  
Author(s):  
Charles Sabbagh ◽  
François Mauvais ◽  
Cyril Cosse ◽  
Lionel Rebibo ◽  
Jean-Paul Joly ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Lymph Nodes ◽  
Lymph Node Ratio ◽  
Disease Free Survival ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
Node Ratio

Abstract Lymph node ratio (LNR) (positive lymph nodes/sampled lymph nodes) is predictive of survival in colon cancer. The aim of the present study was to validate the LNR as a prognostic factor and to determine the optimum LNR cutoff for distinguishing between “good prognosis” and “poor prognosis” colon cancer patients. From January 2003 to December 2007, patients with TNM stage III colon cancer operated on with at least of 3 years of follow-up and not lost to follow-up were included in this retrospective study. The two primary endpoints were 3-year overall survival (OS) and disease-free survival (DFS) as a function of the LNR groups and the cutoff. One hundred seventy-eight patients were included. There was no correlation between the LNR group and 3-year OS (P = 0.06) and a significant correlation between the LNR group and 3-year DFS (P = 0.03). The optimal LNR cutoff of 10% was significantly correlated with 3-year OS (P = 0.02) and DFS (P = 0.02). The LNR was not an accurate prognostic factor when fewer than 12 lymph nodes were sampled. Clarification and simplification of the LNR classification are prerequisites for use of this system in randomized control trials. An LNR of 10% appears to be the optimal cutoff.

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