scholarly journals High-resolution analysis of cis -acting regulatory networks at the α-globin locus

2013 ◽  
Vol 368 (1620) ◽  
pp. 20120361 ◽  
Author(s):  
Jim R. Hughes ◽  
Karen M. Lower ◽  
Ian Dunham ◽  
Stephen Taylor ◽  
Marco De Gobbi ◽  
...  
Keyword(s):  
High Resolution ◽  
Gene Cluster ◽  
Regulatory Networks ◽  
Single Gene ◽  
Regulatory Elements ◽  
Circular Chromosome ◽  
Chromosome Conformation ◽  
Cis Acting ◽  
High Resolution Analysis ◽  
Resolution Analysis

We have combined the circular chromosome conformation capture protocol with high-throughput, genome-wide sequence analysis to characterize the cis -acting regulatory network at a single locus. In contrast to methods which identify large interacting regions (10–1000 kb), the 4C approach provides a comprehensive, high-resolution analysis of a specific locus with the aim of defining, in detail, the cis -regulatory elements controlling a single gene or gene cluster. Using the human α-globin locus as a model, we detected all known local and long-range interactions with this gene cluster. In addition, we identified two interactions with genes located 300 kb (NME4) and 625 kb (FAM173a) from the α-globin cluster.

scholarly journals High-resolution analysis of DNA regulatory elements by synthetic saturation mutagenesis

2009 ◽  
Vol 27 (12) ◽  
pp. 1173-1175 ◽  
Author(s):  
Rupali P Patwardhan ◽  
Choli Lee ◽  
Oren Litvin ◽  
David L Young ◽  
Dana Pe'er ◽  
...  
Keyword(s):  
High Resolution ◽  
Regulatory Elements ◽  
Saturation Mutagenesis ◽  
High Resolution Analysis ◽  
Resolution Analysis ◽  
Dna Regulatory Elements

scholarly journals Evolutionary flexibility in flooding response circuitry in angiosperms

Science ◽  
2019 ◽  
Vol 365 (6459) ◽  
pp. 1291-1295 ◽  
Author(s):  
Mauricio A. Reynoso ◽  
Kaisa Kajala ◽  
Marko Bajic ◽  
Donnelly A. West ◽  
Germain Pauluzzi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
High Resolution ◽  
Gene Regulatory Networks ◽  
Wild Species ◽  
Regulatory Networks ◽  
Chromatin Accessibility ◽  
High Resolution Analysis ◽  
Resolution Analysis ◽  
Gene Regulatory

Flooding due to extreme weather threatens crops and ecosystems. To understand variation in gene regulatory networks activated by submergence, we conducted a high-resolution analysis of chromatin accessibility and gene expression at three scales of transcript control in four angiosperms, ranging from a dryland-adapted wild species to a wetland crop. The data define a cohort of conserved submergence-activated genes with signatures of overlapping cis regulation by four transcription factor families. Syntenic genes are more highly expressed than nonsyntenic genes, yet both can have the cis motifs and chromatin accessibility associated with submergence up-regulation. Whereas the flexible circuitry spans the eudicot-monocot divide, the frequency of specific cis motifs, extent of chromatin accessibility, and degree of submergence activation are more prevalent in the wetland crop and may have adaptive importance.

Very High Resolution Analysis of the Dynamics of a Coronal Plasmoid

1994 ◽  
Vol 144 ◽  
pp. 593-596
Author(s):  
O. Bouchard ◽  
S. Koutchmy ◽  
L. November ◽  
J.-C. Vial ◽  
J. B. Zirker
Keyword(s):  
High Resolution ◽  
Solar Eclipse ◽  
Total Solar Eclipse ◽  
Field Of View ◽  
Small Field ◽  
High Resolution Analysis ◽  
Ccd Observations ◽  
Resolution Analysis ◽  
Very High ◽  
Small Field Of View

AbstractWe present the results of the analysis of a movie taken over a small field of view in the intermediate corona at a spatial resolution of 0.5“, a temporal resolution of 1 s and a spectral passband of 7 nm. These CCD observations were made at the prime focus of the 3.6 m aperture CFHT telescope during the 1991 total solar eclipse.

scholarly journals How to Effectively Control Energy Consumption Growth in China’s 29 Provinces: A Paradigm of Multi-Regional Analysis Based on EAALMDI Method

2021 ◽  
Vol 13 (3) ◽  
pp. 1093
Author(s):  
Yunlong Zhao ◽  
Geng Kong ◽  
Chin Hao Chong ◽  
Linwei Ma ◽  
Zheng Li ◽  
...  
Keyword(s):  
Energy Consumption ◽  
High Resolution ◽  
Energy Policy ◽  
Policy Making ◽  
Regional Analysis ◽  
Policy Implications ◽  
Consumption Growth ◽  
High Resolution Analysis ◽  
Resolution Analysis ◽  
Consumption Control

Controlling energy consumption to reduce greenhouse gas emissions has become a global consensus in response to the challenge of climate change. Most studies have focused on energy consumption control in a single region; however, high-resolution analysis of energy consumption and personalized energy policy-making, for multiple regions with differentiated development, have become a complicated challenge. Using the logarithmic mean Divisia index I (LMDI) decomposition method based on energy allocation analysis (EAA), this paper aims to establish a standard paradigm for a high-resolution analysis of multi-regional energy consumption and provide suggestions for energy policy-making, taking 29 provinces of China as the sample. The process involved three steps: (1) determination of regional priorities of energy consumption control by EAA, (2) revealing regional disparity among the driving forces of energy consumption growth by LMDI, and (3) deriving policy implications by comparing the obtained results with existing policies. The results indicated that 29 provinces can be divided into four groups, with different priorities of energy consumption control according to the patterns of coal flows. Most provinces have increasing levels of energy consumption, driven by increasing per capita GDP and improving living standards, while its growth is restrained by decreasing end-use energy intensity, improving energy supply efficiency, and optimization of industrial structures. However, some provinces are not following these trends to the same degree. This indicates that policy-makers must pay more attention to the different driving mechanisms of energy consumption growth among provinces.

scholarly journals A Back Migration from Asia to Sub-Saharan Africa Is Supported by High-Resolution Analysis of Human Y-Chromosome Haplotypes

2002 ◽  
Vol 70 (5) ◽  
pp. 1197-1214 ◽  
Author(s):  
Fulvio Cruciani ◽  
Piero Santolamazza ◽  
Peidong Shen ◽  
Vincent Macaulay ◽  
Pedro Moral ◽  
...  
Keyword(s):  
High Resolution ◽  
Y Chromosome ◽  
Sub Saharan Africa ◽  
High Resolution Analysis ◽  
Resolution Analysis ◽  
Sub Saharan ◽  
Human Y Chromosome
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