scholarly journals Eye opening differentially modulates inhibitory synaptic transmission in the developing visual cortex

2017 ◽  
Author(s):  
Wuqiang Guan ◽  
Jun-Wei Cao ◽  
Lin-Yun Liu ◽  
Zhi-Hao Zhao ◽  
Yinghui Fu ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Synaptic Transmission ◽  
Animal Development ◽  
Quantal Size ◽  
Excitatory Neurons ◽  
Artificial Opening ◽  
Eye Opening ◽  
Fast Spiking ◽  
And Function ◽  
Mouse Visual Cortex

AbstractEye opening, a natural and timed event during animal development, influences cortical circuit assembly and maturation; yet, little is known about its precise effect on inhibitory synaptic connections. Here we show that coinciding with eye opening, the strength of unitary inhibitory postsynaptic currents (uIPSCs) from somatostatin-expressing interneurons (SST-INs) to nearby excitatory neurons, but not interneurons, sharply decreases in layer 2/3 of the mouse visual cortex. In contrast, the strength of uIPSCs from fast-spiking interneurons (FS-INs) to excitatory neurons significantly increases during eye opening. More importantly, these developmental changes can be prevented by dark rearing or binocular lid suture, and reproduced by artificial opening of sutured lids. Mechanistically, this differential maturation of synaptic transmission is accompanied by a significant change in the postsynaptic quantal size. Together, our study reveals a differential regulation in GABAergic circuits in the cortex driven by eye opening likely crucial for cortical maturation and function.

scholarly journals Eye opening differentially modulates inhibitory synaptic transmission in the developing visual cortex

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Wuqiang Guan ◽  
Jun-Wei Cao ◽  
Lin-Yun Liu ◽  
Zhi-Hao Zhao ◽  
Yinghui Fu ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Synaptic Transmission ◽  
Animal Development ◽  
Quantal Size ◽  
Excitatory Neurons ◽  
Artificial Opening ◽  
Eye Opening ◽  
Fast Spiking ◽  
And Function ◽  
Mouse Visual Cortex

Eye opening, a natural and timed event during animal development, influences cortical circuit assembly and maturation; yet, little is known about its precise effect on inhibitory synaptic connections. Here, we show that coinciding with eye opening, the strength of unitary inhibitory postsynaptic currents (uIPSCs) from somatostatin-expressing interneurons (Sst-INs) to nearby excitatory neurons, but not interneurons, sharply decreases in layer 2/3 of the mouse visual cortex. In contrast, the strength of uIPSCs from fast-spiking interneurons (FS-INs) to excitatory neurons significantly increases during eye opening. More importantly, these developmental changes can be prevented by dark rearing or binocular lid suture, and reproduced by the artificial opening of sutured lids. Mechanistically, this differential maturation of synaptic transmission is accompanied by a significant change in the postsynaptic quantal size. Together, our study reveals a differential regulation in GABAergic circuits in the cortex driven by eye opening may be crucial for cortical maturation and function.

scholarly journals 3D Clustering of GABAergic Neurons Enhances Inhibitory Actions on Excitatory Neurons in the Mouse Visual Cortex

Cell Reports ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. 1896-1907 ◽  
Author(s):  
Teppei Ebina ◽  
Kazuhiro Sohya ◽  
Itaru Imayoshi ◽  
Shu-Ting Yin ◽  
Rui Kimura ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Gabaergic Neurons ◽  
Excitatory Neurons ◽  
Mouse Visual Cortex

scholarly journals Neocortical layer 4 in adult mouse differs in major cell types and circuit organization between primary sensory areas

2018 ◽  
Author(s):  
F. Scala ◽  
D. Kobak ◽  
S. Shan ◽  
Y. Bernaerts ◽  
S. Laturnus ◽  
...  
Keyword(s):  
Adult Mouse ◽  
Building Blocks ◽  
Cell Types ◽  
Excitatory Input ◽  
Excitatory Neurons ◽  
Layer 4 ◽  
Cell Type Specific ◽  
Fast Spiking ◽  
Mouse Visual Cortex ◽  
Whole Cell Recordings

AbstractLayer 4 (L4) of mammalian neocortex plays a crucial role in cortical information processing, yet a complete census of its cell types and connectivity remains elusive. Using whole-cell recordings with morphological recovery, we identified one major excitatory and seven inhibitory types of neurons in L4 of adult mouse visual cortex (V1). Nearly all excitatory neurons were pyramidal and all somatostatin-positive (SOM+) non-fast-spiking neurons were Martinotti cells. In contrast, in somatosensory cortex (S1), excitatory neurons were mostly stellate and SOM+ neurons were non-Martinotti. These morphologically distinct SOM+ interneurons corresponded to different transcriptomic cell types and were differentially integrated into the local circuit with only S1 neurons receiving local excitatory input. We propose that cell-type specific circuit motifs, such as the Martinotti/pyramidal and non-Martinotti/stellate pairs, are optionally used across the cortex as building blocks to assemble cortical circuits.

scholarly journals A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex

2020 ◽  
Author(s):  
Andreas J. Keller ◽  
Mario Dipoppa ◽  
Morgane M. Roth ◽  
Matthew S. Caudill ◽  
Alessandro Ingrosso ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Vasoactive Intestinal Peptide ◽  
Primary Visual Cortex ◽  
Computational Modelling ◽  
Visual Scene ◽  
Inhibitory Neurons ◽  
Contextual Modulation ◽  
Sensory Stimuli ◽  
Excitatory Neurons ◽  
Mouse Visual Cortex

Context guides perception by influencing the saliency of sensory stimuli. Accordingly, in visual cortex, responses to a stimulus are modulated by context, the visual scene surrounding the stimulus. Responses are suppressed when stimulus and surround are similar but not when they differ. The mechanisms that remove suppression when stimulus and surround differ remain unclear. Here we use optical recordings, manipulations, and computational modelling to show that a disinhibitory circuit consisting of vasoactive-intestinal-peptide-expressing (VIP) and somatostatin-expressing (SOM) inhibitory neurons modulates responses in mouse visual cortex depending on the similarity between stimulus and surround. When the stimulus and the surround are similar, VIP neurons are inactive and SOM neurons suppress excitatory neurons. However, when the stimulus and the surround differ, VIP neurons are active, thereby inhibiting SOM neurons and relieving excitatory neurons from suppression. We have identified a canonical cortical disinhibitory circuit which contributes to contextual modulation and may regulate perceptual saliency.

scholarly journals Stability and plasticity of contextual modulation in the mouse visual cortex

2016 ◽  
Author(s):  
Adam Ranson
Keyword(s):  
Visual Cortex ◽  
Activity Level ◽  
Visual Context ◽  
Contextual Modulation ◽  
Long Term Stability ◽  
Highly Active ◽  
Primary Sensory Cortex ◽  
Excitatory Neurons ◽  
Mouse Visual Cortex

SummaryActivity of neurons in primary sensory cortex is shaped by visual and behavioural context. However the long-term stability of the influence of contextual factors in the mature cortex remains poorly understood. To investigate this we used 2-photon calcium imaging to track the influence of surround suppression and locomotion on individual neurons over 14 days. We found that highly active excitatory neurons and PV+ interneurons exhibited relatively stable modulation by visual context. Similarly most neurons exhibited a stable yet distinct degree modulation by locomotion. In contrast less active excitatory neurons exhibited plasticity in visual context influence resulting in increased suppression. These findings suggest that the mature visual cortex possesses stable subnetworks of neurons, differentiated by cell-type and activity level, which have distinctive and stable interactions with sensory and behavioural context, as well as other less active and more labile neurons which are sensitive to visual experience.

scholarly journals Author response: Eye opening differentially modulates inhibitory synaptic transmission in the developing visual cortex

2017 ◽  
Author(s):  
Wuqiang Guan ◽  
Jun-Wei Cao ◽  
Lin-Yun Liu ◽  
Zhi-Hao Zhao ◽  
Yinghui Fu ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Synaptic Transmission ◽  
Author Response ◽  
Inhibitory Synaptic Transmission ◽  
Eye Opening

scholarly journals Pinpointing Morphology and Projection of Excitatory Neurons in Mouse Visual Cortex

2019 ◽  
Vol 13 ◽  
Author(s):  
Yalun Zhang ◽  
Siqi Jiang ◽  
Zhengchao Xu ◽  
Hui Gong ◽  
Anan Li ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Excitatory Neurons ◽  
Mouse Visual Cortex
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