scholarly journals Impaired glucose metabolism in patients with diabetes, prediabetes and obesity is associated with severe Covid-19

2020 ◽  
Author(s):  
Stephen M. Smith ◽  
Avinash Boppana ◽  
Julie A. Traupman ◽  
Enrique Unson ◽  
Daniel A. Maddock ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Glucose Metabolism ◽  
Clinical Characteristics ◽  
Severe Disease ◽  
Impaired Glucose Metabolism ◽  
Disease Pathogenesis ◽  
Patients With Diabetes ◽  
Persistent Hyperglycemia ◽  
Hba1c Levels

AbstractBackgroundIdentification of risk factors of severe Covid-19 is critical for improving therapies and understanding SARS-CoV-2 pathogenesis.MethodsWe analyzed 184 patients hospitalized for Covid-19 in Livingston, New Jersey for clinical characteristics associated with severe disease.ResultsThe majority of Covid-19 patients had diabetes mellitus (DM) (62.0%), Pre-DM (23.9%) with elevated FBG, or a BMI > 30 with normal HbA1C (4.3%). SARS-CoV-2 infection was associated with new and persistent hyperglycemia in 29 patients, including several with normal HbA1C levels. Forty-four patients required intubation, which occurred significantly more often in patients with DM as compared to non-diabetics.ConclusionsSevere Covid-19 occurs in the presence of impaired glucose metabolism in patients with SARS-CoV-2 infection. The association of dysregulated glucose metabolism and severe Covid-19 suggests a previously unrecognized manifestation of primary SARS-CoV-2 infection. Exploration of pathways by which SARS-CoV-2 impacts glucose metabolism is critical for understanding disease pathogenesis and developing therapies.

Effects of Acute Hyperglycemia on Endothelium-Dependent Vasodilation in Patients with Diabetes Mellitus or Impaired Glucose Metabolism

Endothelium ◽  
2003 ◽  
Vol 10 (2) ◽  
pp. 65-70 ◽  
Author(s):  
Sang-Hyun Kim ◽  
Kyung-Woo Park ◽  
Yong-Seok Kim ◽  
Seil Oh ◽  
In-Ho Chae ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Metabolism ◽  
Impaired Glucose Metabolism ◽  
Acute Hyperglycemia ◽  
Patients With Diabetes

scholarly journals FEATURES OF GLYCEMIA INDICES DYNAMICS IN THE COURSE OF SURGICAL TREATMENT OF PATIENTS WITH LOCAL WOUNDS AND DIABETES MELLITUS

2016 ◽  
pp. 53-59
Author(s):  
I. A. Slavnikov ◽  
Z. A. Dundarov
Keyword(s):  
Diabetes Mellitus ◽  
Surgical Treatment ◽  
Carbohydrate Metabolism ◽  
Conservative Therapy ◽  
Impaired Glucose Metabolism ◽  
Antihyperglycemic Therapy ◽  
Different Types ◽  
Patients With Diabetes ◽  
Long Acting ◽  
Persistent Hyperglycemia

Objective: to determine regularities of the dynamics of carbohydrate metabolism indices in the application of various techniques of the treatment for local wounds in patients with diabetes mellitus. Material and methods. We studied the glycemia dynamics in 83 patients with different types and duration of diabetes mellitus who had local wounds of various genesis and limitation period. We applied various ways of conservative therapy and surgical treatment of wound defects and also their combinations in the out-patient conditions of hospital. Hypocarbohydrate diet, various schemes of insulin therapy with short and long acting preparations, oral application of antihyperglycemic preparations of biguanide and sulfonylurea groups, and also their combination were applied as antihyperglycemic therapy. Results. Elimination of local wound defects with a small amount of necrotic mass or its absence in patients with different types of diabetes mellitus by means of various conservative techniques and operative treatment leads to the decrease of prandial glucose concentration in capillary blood. Patients with significant volume of wound detritus did not reveal such a relation. Conclusion. Necrotizing tissues in the area of a local wound defect in patients with impaired glucose metabolism are the cause of persistent hyperglycemia in these patients. This is an unfavorable factor for medicinal compensation of carbohydrate metabolism.

Risk Factors for Hypoglycemia in Patients with Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2271-PUB
Author(s):  
ASAKO MIZOGUCHI
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Patients With Diabetes

scholarly journals When Uncontrolled Diabetes Mellitus and Severe COVID-19 Converge: The Perfect Storm for Mucormycosis

2021 ◽  
Vol 7 (4) ◽  
pp. 298
Author(s):  
Teny M. John ◽  
Ceena N. Jacob ◽  
Dimitrios P. Kontoyiannis
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Clinical Features ◽  
The Other ◽  
Diabetic Patients ◽  
Epidemiological Factors ◽  
Uncontrolled Diabetes ◽  
Diagnostic Certainty ◽  
Patients With Diabetes ◽  
Perfect Storm

Mucormycosis (MCR) has been increasingly described in patients with coronavirus disease 2019 (COVID-19) but the epidemiological factors, presentation, diagnostic certainty, and outcome of such patients are not well described. We review the published COVID-19-associated mucormycosis (CAMCR) cases (total 41) to identify risk factors, clinical features, and outcomes. CAMCR was typically seen in patients with diabetes mellitus (DM) (94%) especially the ones with poorly controlled DM (67%) and severe or critical COVID-19 (95%). Its presentation was typical of MCR seen in diabetic patients (mostly rhino-orbital and rhino-orbital-cerebral presentation). In sharp contrast to reported COVID-associated aspergillosis (CAPA) cases, nearly all CAMCR infections were proven (93%). Treating physicians should have a high suspicion for CAMCR in patients with uncontrolled diabetes mellitus and severe COVID-19 presenting with rhino-orbital or rhino-cerebral syndromes. CAMR is the convergence of two storms, one of DM and the other of COVID-19.

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