scholarly journals Resting Parasympathetic Nervous System Activity is Associated with Greater Antiviral Gene Expression

2021 ◽  
Author(s):  
Danny Rahal ◽  
Sarah M Tashjian ◽  
Maira Karan ◽  
Naomi Eisenberger ◽  
Adriana Galván ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nervous System ◽  
Parasympathetic Nervous System ◽  
Type I ◽  
Sinus Arrhythmia ◽  
System Activity ◽  
Nervous System Activity ◽  
Parasympathetic Nervous System Activity ◽  
Nervous System Function ◽  
Antiviral Gene

Parasympathetic nervous system activity can downregulate inflammation, but it remains unclear how parasympathetic nervous system activity relates to antiviral activity. The present study examined associations between parasympathetic nervous system activity and cellular antiviral gene regulation in 90 adolescents (Mage = 16.3, SD = 0.7; 51.1% female) who provided blood samples and measures of cardiac respiratory sinus arrhythmia (RSA), twice, five weeks apart. Using a multilevel analytic framework, we found that higher RSA (an indicator of higher parasympathetic nervous system activity) - both at rest and during paced breathing - was associated with higher expression of Type I interferon (IFN) response genes in circulating leukocytes, even after adjusting for demographic and biological covariates. RSA was not associated with a parallel measure of inflammatory gene expression. These results identify a previously unrecognized immunoregulatory aspect of autonomic nervous system function and highlight a potential biological pathway by which parasympathetic nervous system activity may relate to health.

scholarly journals Resting parasympathetic nervous system activity is associated with greater antiviral gene expression

2021 ◽  
Vol 98 ◽  
pp. 310-316
Author(s):  
Danny Rahal ◽  
Sarah M. Tashjian ◽  
Maira Karan ◽  
Naomi Eisenberger ◽  
Adriana Galván ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nervous System ◽  
Parasympathetic Nervous System ◽  
System Activity ◽  
Nervous System Activity ◽  
Parasympathetic Nervous System Activity ◽  
Antiviral Gene

scholarly journals Music Attenuated a Decrease in Parasympathetic Nervous System Activity after Exercise

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0148648 ◽  
Author(s):  
Tiantian Jia ◽  
Yoshiko Ogawa ◽  
Misa Miura ◽  
Osamu Ito ◽  
Masahiro Kohzuki
Keyword(s):  
Nervous System ◽  
Parasympathetic Nervous System ◽  
System Activity ◽  
Nervous System Activity ◽  
Parasympathetic Nervous System Activity

Poincaré Plot of Heart Rate Variability Allows Quantitative Display of Parasympathetic Nervous Activity in Humans

1996 ◽  
Vol 91 (2) ◽  
pp. 201-208 ◽  
Author(s):  
Peter Walter Kamen ◽  
Henry Krum ◽  
Andrew Maxwell Tonkin
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Parasympathetic Nervous System ◽  
Poincaré Plot ◽  
System Activity ◽  
Nervous System Activity ◽  
Quartile Range ◽  
Short Period ◽  
Parasympathetic Nervous System Activity

1. Time domain summary statistics and frequency domain parameters can be used to measure heart rate variability. More recently, qualitative methods including the Poincaré plot have been used to evaluate heart rate variability. The aim of this study was to validate a novel method of quantitative analysis of the Poincaré plot using conventional statistical techniques. 2. Beat-to-beat heart rate variability was measured over a relatively short period of time (10–20 min) in 12 healthy subjects aged between 20 and 40 years (mean 30 ± 7 years) during (i) supine rest, (ii) head-up tilt (sympathetic activation, parasympathetic nervous system activity withdrawal), (iii) intravenous infusion of atropine (parasympathetic nervous system activity withdrawal), and (iv) after overnight administration of low-dose transdermal scopolamine (parasympathetic nervous system augmentation). 3. The ‘width’ of the Poincaré plot, as quantified by SD delta R—R (the difference between successive R—R intervals), was determined at rest (median 48.9, quartile range 20 ms) and found to be significantly reduced during tilt (median 19.1, quartile range 13.7 ms, P < 0.01) and atropine administration (median 7.1, quartile range 5.7 ms, P < 0.01) and increased by scopolamine (median 79.3, quartile range 33 ms, P < 0.01). Furthermore, log variance of delta R—R intervals correlated almost perfectly with log high-frequency (0.15–0.4 Hz) power (r = 0.99, P < 0.01). 4. These findings strongly suggest that the ‘width’ of the Poincaré plot is a measure of parasympathetic nervous system activity. The Poincaré plot is therefore a quantitative visual tool which can be applied to the analysis of R—R interval data gathered over relatively short time periods.

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