scholarly journals Impact of SARS-CoV-2 Vaccines on Covid-19 Incidence and Mortality in the United States

2021 ◽  
Author(s):  
Fang Fang ◽  
John David Clemens ◽  
Zuo-Feng Zhang ◽  
Timothy F. Brewer
Keyword(s):  
Negative Binomial ◽  
Herd Immunity ◽  
The United States ◽  
Vaccination Rate ◽  
Vaccine Hesitancy ◽  
Percentage Increase ◽  
Protective Effects ◽  
Vaccination Rates ◽  
Incidence And Mortality ◽  
Before And After

Background: Despite safe and effective vaccines to prevent Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infections and disease, a substantial minority of the US remains resistant to getting vaccinated. It is imperative to know if expanding vaccination rates could reduce community-wide Coronavirus 2019 (COVID-19) disease, not just among those vaccinated. Methods: Negative binomial models were used to estimate associations between U.S. county-level vaccination rates and county-wide COVID-19 incidence and mortality between April 23rd and September 30th, 2021. A two-week lag and a four-week lag were introduced to assess vaccination rate impact on incidence and mortality, respectively. Stratified analyses were performed for county vaccination rates >40%, and before and after Delta became the dominant variant. Findings: Among 3,070 counties, each percentage increase in population vaccination rates reduced county-wide COVID-19 incidence by 0.9% (relative risk (RR) 0.9910 (95% CI: 0.9869, 0.9952)) and mortality by 1.9% (RR 0.9807 (95% CI: 0.9745, 0.9823)). Among counties with vaccination coverage >40%, each percentage increase in vaccination rates reduced COVID-19 disease by 1.5%, RR 0.9850 (95% CI: 0.9793, 0.9952) and mortality by 2.7% (RR 0.9727 (95% CI: 0.9632, 0.9823)). These associations were not observed among counties with <40% vaccination rates. Increasing vaccination rates from 40% to 80% would have reduced COVID-19 cases by 45.4% (RR 0.5458 (95% CI: 0.4335, 0.6873)) and deaths by 67.0% (RR 0.3305 (95% CI: 0.2230, 0.4898)). An estimated 5,989,952 COVID-19 cases could have been prevented and 127,596 lives saved had US population vaccination rates increased from 40% to 80%. Interpretations: Increasing U.S. SARS-CoV-2 vaccination rates results in population-wide reductions in COVID-19 incidence and mortality. Furthermore, increasing vaccination rates above 40% has protective effects among non-vaccinated persons. Given ongoing vaccine hesitancy in the U.S., increasing vaccination rates could better protect the entire community and potentially reach herd immunity. Funding: National Cancer Institute

scholarly journals The Effect of Vaccination Rates on the Infection of COVID-19 under the Vaccination Rate below the Herd Immunity Threshold

2021 ◽  
Vol 18 (14) ◽  
pp. 7491
Author(s):  
Yi-Tui Chen
Keyword(s):  
Infection Rate ◽  
Herd Immunity ◽  
The United States ◽  
Vaccination Rate ◽  
Infection Rates ◽  
Vaccination Rates ◽  
The United Kingdom ◽  
The World ◽  
Almost All ◽  
The Impact

Although vaccination is carried out worldwide, the vaccination rate varies greatly. As of 24 May 2021, in some countries, the proportion of the population fully vaccinated against COVID-19 has exceeded 50%, but in many countries, this proportion is still very low, less than 1%. This article aims to explore the impact of vaccination on the spread of the COVID-19 pandemic. As the herd immunity of almost all countries in the world has not been reached, several countries were selected as sample cases by employing the following criteria: more than 60 vaccine doses per 100 people and a population of more than one million people. In the end, a total of eight countries/regions were selected, including Israel, the UAE, Chile, the United Kingdom, the United States, Hungary, and Qatar. The results find that vaccination has a major impact on reducing infection rates in all countries. However, the infection rate after vaccination showed two trends. One is an inverted U-shaped trend, and the other is an L-shaped trend. For those countries with an inverted U-shaped trend, the infection rate begins to decline when the vaccination rate reaches 1.46–50.91 doses per 100 people.

scholarly journals Getting personal: how vaccination exemptions shape herd immunity

2018 ◽  
Author(s):  
Emma R Nedell ◽  
Romain Garnier ◽  
Saad B Omer ◽  
Shweta Bansal
Keyword(s):  
Policy Change ◽  
Spatial Clustering ◽  
Vaccine Coverage ◽  
Herd Immunity ◽  
The United States ◽  
Vaccine Preventable Diseases ◽  
Vaccination Rates ◽  
Before And After ◽  
Exemption Policy ◽  
Epidemiological Effects

Background: State-mandated school entry immunization requirements in the United States play an important role in achieving high vaccine coverage and preventing outbreaks of vaccine-preventable diseases. Most states allow non-medical exemptions that let children remain unvaccinated on the basis of personal beliefs. However, the ease of obtaining such exemptions varies, resulting in a patchwork of state vaccination exemption laws, contributing to heterogeneity in vaccine coverage across the country. In this study, we evaluate epidemiological effects and spatial variations in non-medical exemption rates in the context of vaccine policies. Methods and Findings: We first analyzed the correlation between non-medical exemption rates and vaccine coverage for three significant childhood vaccinations and found that higher rates of non-medical exemptions were associated with lower vaccination rates of school-aged children in all cases. We then identified a subset of states where exemption policy has recently changed and found that the effects on statewide non-medical exemption rates varied widely. Focusing further on Vermont and California, we illustrated how the decrease in non-medical exemptions due to policy change was concurrent to an increase in medical exemptions (in CA) or religious exemptions (in VT). Finally, a spatial clustering analysis was performed for Connecticut, Illinois, and California, identifying clusters of high non-medical exemption rates in these states before and after a policy change occurred. The clustering analyses show that policy changes affect spatial distribution of non-medical exemptions within a state. Conclusions: Our work suggests that vaccination policies have significant impacts on patterns of herd immunity. Our findings can be used to develop evidence-based vaccine legislation.

scholarly journals COVID-19 Vaccination Rates Are Lowest among Political Outsiders in the United States

2021 ◽  
Author(s):  
Byungkyu Lee ◽  
James Chu
Keyword(s):  
United States ◽  
Presidential Elections ◽  
The United States ◽  
Vaccination Rate ◽  
Longitudinal Survey ◽  
Vaccine Hesitancy ◽  
Vaccination Rates ◽  
Longitudinal Survey Data ◽  
Nationally Representative ◽  
The U.S

Vaccine hesitancy is a critical barrier to widespread vaccination uptake and containment of the COVID-19 pandemic. In the United States, vaccines have become politically polarized, with high rates of vaccine hesitancy observed among Republicans. In contrast to prior research focusing on partisan gaps, we investigate vaccination attitudes and uptake among a group overlooked in prior research: those who are eligible to vote but did not register in the presidential elections. Drawing on nationally representative and longitudinal survey data from April 2020 to October 2021, we show that this group – whom we call “political outsiders” – represents about 16% of the U.S. population. They had the lowest vaccination rate (47%) by 2021 October, significantly lower than Republican (65%), Independent (76%), and Democratic voters (88%). Further, we find that political outsiders are less likely to trust physicians compared to other partisan groups. Because the sources they trust differ from partisans, existing public health messaging may be less likely to reach them successfully. Finally, we find that political outsiders experience more socio-economic hardships and are less integrated into society. Hence, our results underscore the importance of targeted efforts to reach this highly vulnerable population.

scholarly journals COVID-19 and Historic Influenza Vaccinations in the United States: A Comparative Analysis

Vaccines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1284
Author(s):  
Pranav Mirpuri ◽  
Richard A. Rovin
Keyword(s):  
Influenza Vaccination ◽  
The United States ◽  
Vaccination Rate ◽  
Primary Objective ◽  
Vaccine Uptake ◽  
Vaccine Hesitancy ◽  
County Level ◽  
Vaccination Rates ◽  
Global Challenge ◽  
Us Counties

The COVID-19 vaccination effort is a monumental global challenge. Recognizing and addressing the causes of vaccine hesitancy will improve vaccine uptake. The primary objective of this study was to compare the COVID-19 vaccination rates in US counties to historical vaccination rates for influenza in persons aged 65 and older. The secondary objective was to identify county-level demographic, socioeconomic, and political factors that influence vaccination rates. County level data were obtained from publicly available databases for comparison and to create predictive models. Overall, in US counties the COVID-19 vaccination rate exceeded influenza vaccination rates amongst those aged 65 or older (69.4.0% vs. 44%, p < 0.0001). 2690 (83.4%) of 3224 counties had vaccinated 50% or more of their 65 and older residents in the first seven months of the COVID-19 vaccination roll out. There were 467 (14.5%) of 3223 counties in which the influenza vaccination rate exceeded the COVID-19 vaccination rate. Most of these counties were in the Southern region, were considered politically “red” and had a significantly higher non-Hispanic Black resident population (14.4% vs. 8.2%, p < 0.0001). Interventions intended to improve uptake should account for nuances in vaccine access, confidence, and consider factual social media messaging, especially in vulnerable counties.

scholarly journals Factors That Influence Risk Perceptions and Successful COVID-19 Vaccination Communication Campaigns With American Indians

2021 ◽  
pp. 107554702110569
Author(s):  
Amanda D. Boyd ◽  
Dedra Buchwald
Keyword(s):  
American Indians ◽  
Risk Perceptions ◽  
Herd Immunity ◽  
The United States ◽  
Vaccine Hesitancy ◽  
Future Research ◽  
Vaccination Rates ◽  
Culturally Congruent ◽  
Communication Campaigns ◽  
The Impact

COVID-19 vaccinations are the primary tool to end the pandemic. However, vaccine hesitancy continues to be a barrier to herd-immunity in the United States. American Indians (AI) often have higher levels of distrust in western medicine and lower levels of satisfaction with health care when compared to non-Hispanic Whites. Yet AIs have high COVID-19 vaccination rates. We discuss factors that influence AI risk perceptions of COVID-19 vaccinations including the impact of COVID-19 on AI Elders, community, and culture. We conclude with future research needs on vaccination communication and how culturally congruent communication campaigns may have contributed to high COVID-19 vaccination rates.

scholarly journals COVID-19 Vaccination Rates by Global Universal Health Care Coverage Status

2021 ◽  
Vol 5 (1) ◽  
pp. 33-36
Author(s):  
Deepa Dongarwar ◽  
Hamisu M. Salihu
Keyword(s):  
Health Care ◽  
Herd Immunity ◽  
Vaccination Rate ◽  
Universal Health Care ◽  
Vaccination Rates ◽  
Creative Commons ◽  
Universal Health Care Coverage ◽  
Universal Health ◽  
Open Access Article ◽  
Better Than

Healthcare coverage and the type of insurance have always played huge roles in public health outcomes. With coronavirus disease-2019 (COVID-19) vaccination now available across the world, we sought to determine vaccination rates across countries with Universal Health Care (UHC) coverage versus those without. We utilized the vaccination information from the Coronavirus (COVID-19) Vaccinations website, and calculated early vaccination rate for each country as of January, 13, 2021 by dividing the total number of vaccinations given to the total population of the country. We observed that the average early vaccination rate for countries with UHC was 1.55%, whereas that for countries without UHC was 0.51%. Countries with UHC are performing much better than those without UHC in this initial race for providing herd immunity across the globe.   Copyright © 2021 Dongarwar and Salihu. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.

scholarly journals Demographics, perceptions, and socioeconomic factors affecting influenza vaccination among adults in the United States

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5171 ◽  
Author(s):  
Kaja M. Abbas ◽  
Gloria J. Kang ◽  
Daniel Chen ◽  
Stephen R. Werre ◽  
Achla Marathe
Keyword(s):  
United States ◽  
Health Insurance ◽  
Influenza Vaccination ◽  
Vaccine Efficacy ◽  
Herd Immunity ◽  
The United States ◽  
Vaccine Cost ◽  
Factors Affecting ◽  
Vaccination Rates ◽  
Healthy People 2020

Objective The study objective is to analyze influenza vaccination status by demographic factors, perceived vaccine efficacy, social influence, herd immunity, vaccine cost, health insurance status, and barriers to influenza vaccination among adults 18 years and older in the United States. Background Influenza vaccination coverage among adults 18 years and older was 41% during 2010–2011 and has increased and plateaued at 43% during 2016–2017. This is below the target of 70% influenza vaccination coverage among adults, which is an objective of the Healthy People 2020 initiative. Methods We conducted a survey of a nationally representative sample of adults 18 years and older in the United States on factors affecting influenza vaccination. We conducted bivariate analysis using Rao-Scott chi-square test and multivariate analysis using weighted multinomial logistic regression of this survey data to determine the effect of demographics, perceived vaccine efficacy, social influence, herd immunity, vaccine cost, health insurance, and barriers associated with influenza vaccination uptake among adults in the United States. Results Influenza vaccination rates are relatively high among adults in older age groups (73.3% among 75 + year old), adults with education levels of bachelor’s degree or higher (45.1%), non-Hispanic Whites (41.8%), adults with higher incomes (52.8% among adults with income of over $150,000), partnered adults (43.2%), non-working adults (46.2%), and adults with internet access (39.9%). Influenza vaccine is taken every year by 76% of adults who perceive that the vaccine is very effective, 64.2% of adults who are socially influenced by others, and 41.8% of adults with health insurance, while 72.3% of adults without health insurance never get vaccinated. Facilitators for adults getting vaccinated every year in comparison to only some years include older age, perception of high vaccine effectiveness, higher income and no out-of-pocket payments. Barriers for adults never getting vaccinated in comparison to only some years include lack of health insurance, disliking of shots, perception of low vaccine effectiveness, low perception of risk for influenza infection, and perception of risky side effects. Conclusion Influenza vaccination rates among adults in the United States can be improved towards the Healthy People 2020 target of 70% by increasing awareness of the safety, efficacy and need for influenza vaccination, leveraging the practices and principles of commercial and social marketing to improve vaccine trust, confidence and acceptance, and lowering out-of-pocket expenses and covering influenza vaccination costs through health insurance.

scholarly journals ImmunizziAMO: A School-Based Field Trial to Teach New Generations the Importance of Vaccination through Games and to Fight Vaccine Hesitancy in Italy

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 280
Author(s):  
Giuseppe La Torre ◽  
Valeria D’Egidio ◽  
Cristina Sestili ◽  
Rosario Andrea Cocchiara ◽  
Sara Cianfanelli ◽  
...  
Keyword(s):  
Elementary School ◽  
Field Trial ◽  
Herd Immunity ◽  
Immunological Response ◽  
Knowledge Score ◽  
First Grade ◽  
Vaccine Hesitancy ◽  
School Based ◽  
Before And After ◽  
First Contact

Background: Vaccines simulate the first contact with infectious agents and evoke the immunological response without causing the disease and its complications. High rates of immunization among the population guarantee the interruption of the transmission chain of infectious diseases. Therefore, the population should be aware of the value of vaccination and motivated. In order to implement the spread of a correct culture about these issues, schools were recognized as a privileged operational setting. The aim of this project was to transmit knowledge and convey educational messages on the importance of vaccines, through the use of games, in elementary school children, their families and teachers. Materials and Methods: A field trial study was implemented between April and October 2019. Sample size calculations highlighted the need to recruit at least 136 students in the schools. The intervention involved 10 classes (five first grade and five s grade classes) and was structured in frontal teaching sessions and gaming sessions. Knowledge was assessed comparing the results of a questionnaire administered before and after the intervention. The questionnaires referred to the following items: dangerousness of bacteria and viruses; capability of defending from microorganisms; the role of antibodies; functioning of the vaccine in a child; type of disease for which a vaccine is efficacious; duration of a vaccine; mother- child transmission of antibodies; herd immunity. Results: 143 children participated in all the phases of the study. The comparison between the scores at the beginning and end of the intervention showed a significant increase in the knowledge about vaccines and immunity. The mean knowledge score arose from 3.52 (SD = 1.67) to 5.97 (SD = 1.81). Conclusions: This study suggests that the use of games in an elementary school effectively increase the knowledge related to the important topic of vaccination starting at childhood.

scholarly journals Spatial Modeling of COVID-19 Vaccine Hesitancy in the United States

2021 ◽  
Vol 18 (18) ◽  
pp. 9488
Author(s):  
Abolfazl Mollalo ◽  
Moosa Tatar
Keyword(s):  
United States ◽  
Healthcare Providers ◽  
Vulnerability Index ◽  
The United States ◽  
Vaccine Hesitancy ◽  
Social Vulnerability Index ◽  
Vaccination Programs ◽  
Public Health Decision ◽  
Vaccination Rates ◽  
The Impact

Vaccine hesitancy refers to delay in acceptance or refusal of vaccines despite the availability of vaccine services. Despite the efforts of United States healthcare providers to vaccinate the bulk of its population, vaccine hesitancy is still a severe challenge that has led to the resurgence of COVID-19 cases to over 100,000 people during early August 2021. To our knowledge, there are limited nationwide studies that examined the spatial distribution of vaccination rates, mainly based on the social vulnerability index (SVI). In this study, we compiled a database of the percentage of fully vaccinated people at the county scale across the continental United States as of 29 July 2021, along with SVI data as potential significant covariates. We further employed multiscale geographically weighted regression to model spatial nonstationarity of vaccination rates. Our findings indicated that the model could explain over 79% of the variance of vaccination rate based on Per capita income and Minority (%) (with positive impacts), and Age 17 and younger (%), Mobile homes (%), and Uninsured people (%) (with negative effects). However, the impact of each covariate varied for different counties due to using separate optimal bandwidths. This timely study can serve as a geospatial reference to support public health decision-makers in forming region-specific policies in monitoring vaccination programs from a geographic perspective.

scholarly journals COVID-19: Cross Reactive Immunity, Herd Immunity, and Convalescent Serum Therapy

2021 ◽  
pp. 387-402
Author(s):  
Nahla Khamis Ibrahim ◽  
Hala Abubaker A. Bagabir
Keyword(s):  
Prevention And Control ◽  
Herd Immunity ◽  
Oral Polio Vaccine ◽  
Therapeutic Effects ◽  
Protective Effects ◽  
Mmr Vaccine ◽  
Incidence And Mortality ◽  
Serum Therapy ◽  
Cross Immunity ◽  
And Control

Objective: To present various types of vaccines and viral infections which can induce cross-reactive immunity against COVID-19. In addition, this article discusses the role of herd immunity and convalescent serum therapy in preventing and controlling SARS CoV-2. The study also determined the claims and counterclaims about their protective and therapeutic effects. Method: Non-systematic review was done using different articles done on cross-reactive immunity against COVID-19 through vaccinations, previous infections, herd immunity and the therapeutic effects of convalescence serum. The search was done on the PubMed, Google Scholar, and Science Direct, WHO, Euro-surveillance, CDC databases.   Results: Many observational correlational studies reported that BCG decreases the incidence and mortality from COVID-19. Furthermore, homology between the COVID-19 virus and the measles, mumps, and rubella (MMR) viruses was discovered. Few studies suggested the presence of cross-immunity between MMR vaccine and SARS-CoV-2. Similarly, few studies suggested protective effects of Oral Polio Vaccine (OPV) against SARS-CoV-2; since both viruses are positive-single-strand RNA (+ssRNA). Diphtheria, pertussis, and tetanus (DPT) vaccines, particularly those that include inactivated whole pertussis vaccine, might induce B and T cell cross-reactive immunity against SARS-CoV-2. Other vaccines against Streptococcus pneumonia, Haemophilus influenza, and Meningococcal meningitis vaccines are suggested also to induce some immunity against Covid-19.  It is hypothesized that infections with other Coronaviruses may cause protection against SARS-CoV-2. However, the studies done on these suggestions were mostly observational that can carry a high chance of inherent biases. There are also claims and counterclaims about the effect of herd immunity and convalescence serum on the prevention and control of Covid-19. So, appropriately designed RCTs are needed to prove or disprove their protective and therapeutic effects. Conclusions: There are claims and counterclaims about the protective effects of different vaccines, previous infections, and herd immunity and regarding the therapeutic effects of convalescence serum. Comparing with other vaccines, BCG was suggested to have the highest cross-reactive epitopes against SARS-Cov-2 virus. MMR, OPV, DPT, Influenza, Pneumococcal and meningococcal vaccines are suggested to protect against Covid-19. Previous infection with other Corona viruses, herd immunity and convalescence serum may play roles in the prevention and control of Covid-19. Many large clinical trials are undergoing nowadays and their results are needed to prove or disprove the cross-immunity related to SARS-CoV-2 and the effect of convalescence serum.

Sign in / Sign up

Export Citation Format

Share Document