scholarly journals IMU-derived kinematics detect gait differences with age or knee osteoarthritis but differ from marker-derived inverse kinematics

2022 ◽  
Author(s):  
Jocelyn F Hafer ◽  
Julien A Mihy ◽  
Andrew Hunt ◽  
Ronald F Zernicke ◽  
Russell T Johnson
Keyword(s):  
Older Adults ◽  
Knee Osteoarthritis ◽  
Real World ◽  
Inverse Kinematics ◽  
Plantar Flexion ◽  
Group Differences ◽  
Overground Walking ◽  
Gait Mechanics ◽  
Measurement Units ◽  
Derived Data

Common in-lab, marker-based gait analyses may not represent daily, real-world gait. Real-world gait analyses may be feasible using inertial measurement units (IMUs), especially with recent advancements in open-source methods (e.g., OpenSense). Before using OpenSense to study real-world gait, we must determine whether these methods: (1) estimate joint kinematics similarly to traditional marker-based motion capture (MoCap) and (2) differentiate groups with clinically different gait mechanics. Healthy young and older adults and older adults with knee osteoarthritis completed this study. We captured MoCap and IMU data during overground walking at self-selected and faster speeds. MoCap and IMU kinematics were computed with appropriate OpenSim workflows. We tested whether sagittal kinematics differed between MoCap- and IMU-derived data, whether tools detected between-group differences similarly, and whether kinematics differed between tools by speed. MoCap data showed more flexion than IMU data (hip: 0-47 and 65-100% stride, knee: 0-38 and 58-91% stride, ankle: 18-100% stride). Group kinematics differed at the hip (young extension > knee osteoarthritis at 30-47% stride) and ankle (young plantar flexion > older healthy at 62-65% stride). Group-by-tool interactions occurred at the hip (61-63% stride). Significant tool-by-speed interactions were found, with hip and knee flexion increasing more for MoCap than IMU data with speed (hip: 12-15% stride, knee: 60-63% stride). While MoCap- and IMU-derived kinematics differed, our results suggested that the tools similarly detected clinically meaningful differences in gait. Results of the current study suggest that IMU-derived kinematics with OpenSense may enable the valid and reliable evaluation of gait in real-world, unobserved settings.

scholarly journals CAPTURING REAL-WORLD LOSSES OF BALANCE AND RECOVERY RESPONSES IN OLDER ADULTS AT RISK FOR FALLS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S9-S9
Author(s):  
Neil Alexander ◽  
Shirley Handelzalts-Pereg ◽  
Linda Nyquist ◽  
Debbie Strasburg ◽  
Nicholas Mastruserio ◽  
...  
Keyword(s):  
Older Adults ◽  
At Risk ◽  
Real World ◽  
Trunk Motion ◽  
Falls In Older Adults ◽  
Measurement Units ◽  
Near Falls ◽  
Voice Recorder ◽  
The Voice ◽  
Full Body

Abstract Losses of balance (LOBs) such as trips can lead to falls in older adults; what actually happens during real-world LOBs is unclear. With 4 wearable inertial measurement units (IMUs), we recorded feet, trunk and wrist movements over 2 weeks. Using a wrist voice recorder to report the LOBs, we applied our IMU processing algorithms and reconstructed the full body LOB and recovery motions. We recruited 7 at-risk older adults (M=76 yrs) who reported 114 LOBs of which we reconstructed over 90%. Using a rating system, 52% of the LOBs involved a significant trip, stumble, recovery step, and/or large trunk motion. 25% involved double or stutter steps and smaller trunk motions. The other 23% had less striking associated motions. These data suggest that most, but not all, self-reported real world LOBs involve substantial postural destabilization and near falls. Analyses of the voice-recorded context under which the LOBs occurred are ongoing.

Effects of Long-Term Aerobic or Weight Training Regimens on Gait in an Older, Osteoarthritic Population

1997 ◽  
Vol 13 (2) ◽  
pp. 205-225 ◽  
Author(s):  
Stephen P. Messier ◽  
Christopher D. Thompson ◽  
Walter H. Ettinger
Keyword(s):  
Older Adults ◽  
Health Education ◽  
Knee Osteoarthritis ◽  
Knee Pain ◽  
Exercise Intervention ◽  
Weight Training ◽  
Plantar Flexion ◽  
Long Term Effects ◽  
Education Group

The purpose of this study was to determine the long-term effects of aerobic walking and weight training interventions on gait mechanics and knee pain in older adults with knee osteoarthritis (OA). One hundred three older adults (age ≥60 years) with radio-graphic evidence of knee OA were randomized to one of three treatment groups: aerobic walking, health education control, or weight training. Both exercise intervention groups exercised 3 days · week-1 for 18 months. The aerobic group significantly improved temporal components of gait as well as knee and ankle joint kinematics relative to the health education group across the 18-month intervention. Moreover, the weight training group exhibited significantly greater ankle plantar flexion velocity. Analysis of the ground reaction forces indicated that the aerobic group exhibited significantly greater force relative to the health education group. Finally, both exercise groups exhibited significantly less knee pain than the health education group. The results suggest that long-term aerobic walking and, to a lesser extent, weight training regimens improve walking mechanics in older adults with knee osteoarthritis. These improvements in gait are associated with a reduction in knee pain during activities of daily living.

Studying Multilingualism and Group Differences in Adult Communication

2010 ◽  
Vol 17 (3) ◽  
pp. 59-64
Author(s):  
Loraine K. Obler
Keyword(s):  
Older Adults ◽  
Research Center ◽  
Group Differences ◽  
Aging Brain

The focus of this article is on the study of bilingual and multilingual adults at the Howard Goodglass Aphasia Research Center and the Language in the Aging Brain Laboratory by Drs. Obler and Albert along with former students and colleagues. Summaries of studies examining research in healthy bilingual adults, healthy monolingual older adults, and monolingual and bilingual individuals with aphasia are presented.

scholarly journals Reliability of Bi-Axial Ankle Stiffness Measurement in Older Adults

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1162
Author(s):  
Hogene Kim ◽  
Sangwoo Cho ◽  
Hwiyoung Lee
Keyword(s):  
Older Adults ◽  
Range Of Motion ◽  
Angular Displacement ◽  
Plantar Flexion ◽  
Significant Negative Correlation ◽  
Talocrural Joint ◽  
Ankle Foot Orthosis ◽  
Ankle Stiffness ◽  
Ankle Movement ◽  
Test Retest Reliability

This study involves measurements of bi-axial ankle stiffness in older adults, where the ankle joint is passively moved along the talocrural and subtalar joints using a custom ankle movement trainer. A total of 15 elderly individuals participated in test–retest reliability measurements of bi-axial ankle stiffness at exactly one-week intervals for validation of the angular displacement in the device. The ankle’s range of motion was also compared, along with its stiffness. The kinematic measurements significantly corresponded to results from a marker-based motion capture system (dorsi-/plantar flexion: r = 0.996; inversion/eversion: r = 0.985). Bi-axial ankle stiffness measurements showed significant intra-class correlations (ICCs) between the two visits for all ankle movements at slower (2.14°/s, ICC = 0.712) and faster (9.77°/s, ICC = 0.879) speeds. Stiffness measurements along the talocrural joint were thus shown to have significant negative correlation with active ankle range of motion (r = −0.631, p = 0.012). The ankle movement trainer, based on anatomical characteristics, was thus used to demonstrate valid and reliable bi-axial ankle stiffness measurements for movements along the talocrural and subtalar joint axes. Reliable measurements of ankle stiffness may help clinicians and researchers when designing and fabricating ankle-foot orthosis for people with upper-motor neuron disorders, such as stroke.

scholarly journals EEG Measures of Value-Directed Strategic Processing in Older Adults With and Without Mild Cognitive Impairment

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 292-293
Author(s):  
Lydia Nguyen ◽  
Shraddha Shende ◽  
Daniel Llano ◽  
Raksha Mudar
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Aging ◽  
Spectral Power ◽  
Group Differences ◽  
Cognitive Resources ◽  
Alpha Power ◽  
Strategic Processing ◽  
Unique Word

Abstract Value-directed strategic processing is important for daily functioning. It allows selective processing of important information and inhibition of irrelevant information. This ability is relatively preserved in normal cognitive aging, but it is unclear if mild cognitive impairment (MCI) affects strategic processing and its underlying neurophysiological mechanisms. The current study examined behavioral and EEG spectral power differences between 16 cognitively normal older adults (CNOA; mean age: 74.5 ± 4.0 years) and 16 individuals with MCI (mean age: 77.1 ± 4.3 years) linked to a value-directed strategic processing task. The task used five unique word lists where words were assigned high- or low-value based on letter case and were presented sequentially while EEG was recorded. Participants were instructed to recall as many words as possible after each list to maximize their score. Results revealed no group differences in recall of low-value words, but individuals with MCI recalled significantly fewer high-value words and total number of words relative to CNOA. Group differences were observed in theta and alpha bands for low-value words, with greater synchronized theta power for CNOA than MCI and greater desynchronized alpha power for MCI than CNOA. Collectively, these findings demonstrate that more effortful neural processing of low-value words in the MCI group, relative to the CNOA group, allowed them to match their behavioral performance to the CNOA group. Individuals with MCI appear to utilize more cognitive resources to inhibit low-value information and might show memory-related benefits if taught strategies to focus on high-value information processing.

scholarly journals 1012. Efficacy, safety and tolerability of switching to bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in HIV-1 infected virologically-suppressed older adults in a real-world setting

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S534-S535
Author(s):  
Charlotte-Paige M Rolle ◽  
Vu Nguyen ◽  
Kiran Patel ◽  
Dan Cruz ◽  
Federico Hinestrosa ◽  
...  
Keyword(s):  
Older Adults ◽  
Drug Interactions ◽  
Real World ◽  
Research Study ◽  
Panel Member ◽  
Median Number ◽  
Research Support ◽  
Review Panel ◽  
Study Investigator ◽  
Hiv 1

Abstract Background Approximately 50% of people living with HIV (PLWH) in the United States are ≥50 years old. Efforts are ongoing to identify antiretrovirals associated with fewer drug-drug interactions (DDIs) and long-term side effects in this group. Clinical trials of B/F/TAF demonstrated favorable efficacy and safety in older adults, however, data from real-word settings are needed to validate these results. Methods This retrospective analysis evaluated records from PLWH aged ≥ 50 years at the Orlando Immunology Center who were switched to B/F/TAF between 2/7/2018 and 5/31/2019. Eligible patients had baseline HIV-1 RNA< 50 copies/mL and were followed for 48 weeks post-switch. The primary endpoint was maintenance of HIV-1 RNA< 50 copies/mL at week 48. The impact of switching to B/F/TAF on DDIs, adverse events (AEs) and safety parameters were analyzed throughout the study. Results 306 patients met inclusion criteria. 62 (20%) were female, 126 (41%) were non-white, median age was 58 years (range [r] 50-81), median duration of HIV infection was 19.5 years (r 2-40), median number of chronic co-morbid conditions was 5 (r 0-20), and median number of baseline concomitant medications was 4 (r 0-23). 159 (52%) patients were switched from regimens containing ritonavir or cobicistat. The most commonly documented reason for switch was simplification (Table 1). At Week 48, 287 (94%) patients maintained an HIV-1 RNA< 50 copies/ml and 19 (6%) had an HIV-1 RNA between 50-200 copies/mL (Figure 1). 1 patient discontinued due to lack of efficacy. A total of 123 potential DDIs were identified in 104 (34%) patients taking a boosting agent or rilpivirine at baseline (Table 2). At Week 48, there was a significant median decline in total cholesterol (15.5 mg/dL, 95% confidence interval [CI]: 9.5; 21.5), LDL cholesterol (9.5 mg/dL, 95% CI: 4; 15.5) and triglycerides (20 mg/dL, 95% CI: 9.5; 32.5), and median weight increased by 2.5 pounds (95% CI: 1.5; 3.5). Treatment-related AEs occurred in 33 (11%) patients (all Grade 1-2) and led to 7 (2%) discontinuations. Table 1-Baseline demographic and clinical characteristics Table 2-Avoidance of Drug-Drug Interactions (DDIs) following switch to B/F/TAF Figure 1-Subgroup analysis of virologic outcomes at Week 48 Conclusion In this real-world cohort, switching to B/F/TAF was associated with maintenance of virologic control, improvement in lipid parameters, and avoidance of DDIs in a large proportion of patients. These data support use of B/F/TAF as a treatment option in older PLWH. Disclosures Charlotte-Paige M. Rolle, MD MPH, Gilead Sciences (Grant/Research Support, Scientific Research Study Investigator, Speaker’s Bureau)Janssen Infectious Disease (Grant/Research Support)ViiV Healthcare (Grant/Research Support, Scientific Research Study Investigator, Advisor or Review Panel member, Speaker’s Bureau) Kiran Patel, PharmD, Gilead Sciences (Employee) Federico Hinestrosa, MD, AbbVie (Speaker’s Bureau)Gilead Sciences (Speaker’s Bureau)Merck (Speaker’s Bureau)Theratechnologies (Speaker’s Bureau) Edwin DeJesus, MD, Gilead Sciences (Advisor or Review Panel member)

scholarly journals Effects of aging on emotion recognition from dynamic multimodal expressions and vocalizations

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Diana S. Cortes ◽  
Christina Tornberg ◽  
Tanja Bänziger ◽  
Hillary Anger Elfenbein ◽  
Håkan Fischer ◽  
...  
Keyword(s):  
Older Adults ◽  
Emotion Recognition ◽  
Positive Emotions ◽  
Negative Emotions ◽  
Group Differences ◽  
Significant Group ◽  
Positivity Effect ◽  
Video Recordings ◽  
Age Related ◽  
Effects Of Aging

AbstractAge-related differences in emotion recognition have predominantly been investigated using static pictures of facial expressions, and positive emotions beyond happiness have rarely been included. The current study instead used dynamic facial and vocal stimuli, and included a wider than usual range of positive emotions. In Task 1, younger and older adults were tested for their abilities to recognize 12 emotions from brief video recordings presented in visual, auditory, and multimodal blocks. Task 2 assessed recognition of 18 emotions conveyed by non-linguistic vocalizations (e.g., laughter, sobs, and sighs). Results from both tasks showed that younger adults had significantly higher overall recognition rates than older adults. In Task 1, significant group differences (younger > older) were only observed for the auditory block (across all emotions), and for expressions of anger, irritation, and relief (across all presentation blocks). In Task 2, significant group differences were observed for 6 out of 9 positive, and 8 out of 9 negative emotions. Overall, results indicate that recognition of both positive and negative emotions show age-related differences. This suggests that the age-related positivity effect in emotion recognition may become less evident when dynamic emotional stimuli are used and happiness is not the only positive emotion under study.

scholarly journals Performance in complex life situations: effects of age, cognition, and walking speed in virtual versus real life environments

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Michal Kafri ◽  
Patrice L. Weiss ◽  
Gabriel Zeilig ◽  
Moshe Bondi ◽  
Ilanit Baum-Cohen ◽  
...  
Keyword(s):  
Older Adults ◽  
Heart Rate ◽  
Virtual Environment ◽  
Real World ◽  
Age Groups ◽  
Age Effects ◽  
Shopping Mall ◽  
Complex Task ◽  
The Real ◽  
Gait Parameters

Abstract Background Virtual reality (VR) enables objective and accurate measurement of behavior in ecologically valid and safe environments, while controlling the delivery of stimuli and maintaining standardized measurement protocols. Despite this potential, studies that compare virtual and real-world performance of complex daily activities are scarce. This study aimed to compare cognitive strategies and gait characteristics of young and older healthy adults as they engaged in a complex task while navigating in a real shopping mall and a high-fidelity virtual replica of the mall. Methods Seventeen older adults (mean (SD) age = 71.2 (5.6) years, 64% males) and 17 young adults (26.7 (3.7) years, 35% males) participated. In two separate sessions they performed the Multiple Errands Test (MET) in a real-world mall or the Virtual MET (VMET) in the virtual environment. The real-world environment was a small shopping area and the virtual environment was created within the CAREN™ (Computer Assisted Rehabilitation Environment) Integrated Reality System. The performance of the task was assessed using motor and physiological measures (gait parameters and heart rate), MET or VMET time and score, and navigation efficiency (cognitive performance and strategy). Between (age groups) and within (environment) differences were analyzed with ANOVA repeated measures. Results There were no significant age effects for any of the gait parameters but there were significant environment effects such that both age groups walked faster (F(1,32) = 154.96, p < 0.0001) with higher step lengths (F(1,32) = 86.36, p < 0.0001), had lower spatial and temporal gait variability (F(1,32) = 95.71–36.06, p < 0.0001) and lower heart rate (F(1,32) = 13.40, p < 0.01) in the real-world. There were significant age effects for MET/VMET scores (F(1,32) = 19.77, p < 0.0001) and total time (F(1,32) = 11.74, p < 0.05) indicating better performance of the younger group, and a significant environment effect for navigation efficiency (F(1,32) = 7.6, p < 0.01) that was more efficient in the virtual environment. Conclusions This comprehensive, ecological approach in the measurement of performance during tasks reminiscent of complex life situations showed the strengths of using virtual environments in assessing cognitive aspects and limitations of assessing motor aspects of performance. Difficulties by older adults were apparent mainly in the cognitive aspects indicating a need to evaluate them during complex task performance.

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