scholarly journals Firing-Rate Based Network Modeling of the dLGN Circuit: Effects of Cortical Feedback on Spatiotemporal Response Properties of Relay Cells

2018 ◽  
Author(s):  
Milad Hobbi Mobarhan ◽  
Geir Halnes ◽  
Pablo Martínez-Cañada ◽  
Torkel Hafting ◽  
Marianne Fyhn ◽  
...  
Keyword(s):  
Firing Rate ◽  
Visual Responses ◽  
Cortical Cells ◽  
Feedback Effects ◽  
Difference Of Gaussians ◽  
Cortical Feedback ◽  
Inhibitory Feedback ◽  
Pass Through ◽  
Flow Of Information

AbstractVisual signals originating in the retina pass through the dorsal geniculate nucleus (dLGN), the visual part of thalamus, on the way to the visual cortex. This is however not a simple feedforward flow of information: there is a significant feedback from cortical cells back to both relay cells and interneurons in the dLGN. Despite four decades of experimental and theoretical studies, the functional role of this feedback is still debated. Here we use a firing-rate model, the extended difference-of-gaussians (eDOG) model, to explore cortical feedback effects on visual responses of dLGN relay cells. For this model the responses are found by direct evaluation of two- or three-dimensional integrals allowing for fast and comprehensive studies of putative effects of different candidate organizations of the cortical feedback. Our analysis identifies a special mixed configuration of excitatory and inhibitory cortical feedback which seems to best account for available experimental data. This configuration consists of a slow (long-delay) and spatially widespread inhibitory feedback, combined with a fast (short-delayed) and spatially narrow excitatory feedback, where (iii) the excitatory/inhibitory ON-ON connections are accompanied respectively by inhibitory/excitatory OFF-ON connections, i.e. following a phase-reversed arrangement. The recent development of optogenetic and pharmacogenetic methods has provided new tools for more precise manipulation and investigation of the thalamocortical circuit, in particular for mice. Such data will expectedly allow the eDOG model to be better constrained by data from specific animal model systems than has been possible until now for cat. We have therefore made the Python tool pyLGN which allows for easy adaptation of the eDOG model to new situations.Author SummaryOn route from the retina to primary visual cortex, visually evoked signals have to pass through the dorsal lateral geniculate nucleus (dLGN). However, this is not an exclusive feed forward flow of information as feedback exists from neurons in the cortex back to both relay cells and interneurons in the dLGN. The functional role of this feedback remains mostly unresolved. Here, we use a firing-rate model, the extended difference-of-gaussians (eDOG) model, to explore cortical feedback effects on visual responses of dLGN relay cells. Our analysis indicates that a particular mix of excitatory and inhibitory cortical feedback agrees best with available experimental observations. In this configuration ON-center relay cells receive both excitatory and (indirect) inhibitory feedback from ON-center cortical cells (ON-ON feedback) where the excitatory feedback is fast and spatially narrow while the inhibitory feedback is slow and spatially widespread. In addition to the ON-ON feedback, the connections are accompanied by OFF-ON connections following a so-called phase-reversed (push-pull) arrangement. To facilitate further applications of the model, we have made the Python tool pyLGN which allows for easy modification and evaluation of the a priori quite general eDOG model to new situations.

Suppression of NMDA Receptor Function Using Antisense DNA Blocks Ocular Dominance Plasticity While Preserving Visual Responses

1998 ◽  
Vol 80 (3) ◽  
pp. 1021-1032 ◽  
Author(s):  
Elizabeth B. Roberts ◽  
M. Alex Meredith ◽  
Ary S. Ramoa
Keyword(s):  
Nmda Receptor ◽  
Nmda Receptors ◽  
Ocular Dominance ◽  
Receptor Function ◽  
Visual Responses ◽  
Ocular Dominance Plasticity ◽  
Cortical Cells ◽  
Nmda Receptor Function ◽  
Sensory Responses

Roberts, Elizabeth B., M. Alex Meredith, and Ary S. Ramoa. Suppression of NMDA receptor function using antisense DNA blocks ocular dominance plasticity while preserving visual responses. J. Neurophysiol. 80: 1021–1032, 1998. Pioneering work has shown that pharmacological blockade of the N-methyl-d-aspartate (NMDA) receptor channel reduces ocular dominance plasticity. However, the results also show that doses of NMDA receptor antagonists that have an effect on ocular dominance plasticity profoundly reduce sensory responses and disrupt stimulus selectivity of cortical cells. It is, therefore, not possible to determine whether effects of NMDA receptor blockade on visual plasticity result from a specific role of NMDA receptors or from the reduction in sensory response. We have used an alternate approach to examine this question. We performed knockdown experiments using antisense oligodeoxynucleotides (ODNs) complementary to mRNA coding the NR1 subunit of the NMDA receptor. After 5 days of antisense, but not sense, ODN treatment NMDA receptor–mediated synaptic transmission was reduced markedly relative to the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor response, as indicated by whole cell patch-clamp recordings in the cortical slice preparation. This suppression of NMDA receptor–mediated currents was due to a selective reduction in the NR1 protein near the injection site relative to the untreated hemisphere in the same animal, as indicated by immunocytochemistry and Western blotting. In contrast, AMPA receptors were not affected by the antisense ODN treatment indicating specificity of effects. Another major effect of this treatment was to decrease ocular dominance plasticity. Ferrets that were monocularly deprived 1 wk during the antisense ODN treatment had ocular dominance histograms similar to those found in untreated, nondeprived animals. In contrast, ferrets treated with sense ODN and monocularly deprived had ocular dominance histograms resembling those of untreated, monocularly deprived animals. The effects on ocular dominance plasticity did not result from a disruption of sensory responses because maximum responses as well as orientation and direction selectivity of cortical cells were not affected by the treatment. In conclusion, the present results show that antisense techniques can accomplish more selective manipulations of cortical function than is possible with traditional pharmacological agents. Use of this approach also provides unambiguous evidence for a specific role of NMDA receptors in visual plasticity.

scholarly journals Circulating Secretin Activates Supraoptic Nucleus Oxytocin and Vasopressin Neurons via Noradrenergic Pathways in the Rat

Endocrinology ◽  
2010 ◽  
Vol 151 (6) ◽  
pp. 2681-2688 ◽  
Author(s):  
Sathya Velmurugan ◽  
Paula J. Brunton ◽  
Gareth Leng ◽  
John A. Russell
Keyword(s):  
Amino Acid ◽  
Firing Rate ◽  
Noradrenaline Release ◽  
Supraoptic Nucleus ◽  
Female Rats ◽  
Adrenoceptor Antagonist ◽  
Intracerebroventricular Infusion ◽  
Neuroendocrine Neurons ◽  
Vasopressin Neurons

Secretin is a 27-amino acid brain-gut peptide from duodenal S-cells. We tested the effects of systemic administration of secretin to simulate its postprandial release on neuroendocrine neurons of the supraoptic nucleus (SON) in urethane-anesthetized female rats. Secretin dose-dependently increased the firing rate of oxytocin neurons, more potently than cholecystokinin, and dose-dependently increased plasma oxytocin concentration. The effect of secretin on SON vasopressin neurons was also predominantly excitatory, in contrast to the inhibitory actions of cholecystokinin. To explore the involvement of noradrenergic inputs in secretin-induced excitation, benoxathian, an α1-adrenoceptor antagonist, was infused intracerebroventricularly. Benoxathian intracerebroventricular infusion blocked the excitation by secretin of both oxytocin and vasopressin neurons. To test the role of local noradrenaline release in the SON, benoxathian was microdialyzed onto the SON. The basal firing rate of oxytocin neurons was slightly reduced and the secretin-induced excitation was attenuated during benoxathian microdialysis. Hence, noradrenergic pathways mediate the excitation by systemic secretin of oxytocin neurons via α1-adrenoceptors in the SON. As both systemic secretin and oxytocin are involved in regulating gastrointestinal functions and natriuresis, systemically released secretin might act partly through oxytocin.

The influence of discourse context on children's provision of auxiliary BE

2008 ◽  
Vol 35 (1) ◽  
pp. 129-158 ◽  
Author(s):  
ANNA L. THEAKSTON ◽  
ELENA V. M. LIEVEN
Keyword(s):  
Language Acquisition ◽  
Word Order ◽  
Current Paper ◽  
Discourse Context ◽  
Linguistic Representations ◽  
Prior Use ◽  
Single Child ◽  
Pass Through ◽  
Children's Speech

ABSTRACTChildren pass through a stage in development when they produce utterances that contain auxiliary BE (he's playing) and utterances where auxiliary BE is omitted (he playing). One explanation that has been put forward to explain this phenomenon is the presence of questions in the input that model S-V word order (Theakston, Lieven & Tomasello, 2003). The current paper reports two studies that investigate the role of the input in children's use and non-use of auxiliary BE in declaratives. In Study 1, 96 children aged from 2 ; 5 to 2 ; 10 were exposed to known and novel verbs modelled in questions only or declaratives only. In Study 2, naturalistic data from a dense database from a single child between the ages of 2 ; 8 to 3 ; 2 were examined to investigate the influence of (1) declaratives and questions in the input in prior discourse, and (2) the child's immediately previous use of declaratives where auxiliary BE was produced or omitted, on his subsequent use or non-use of auxiliary BE. The results show that in both the experimental and naturalistic contexts, the presence of questions in the input resulted in lower levels of auxiliary provision in the children's speech than in utterances following declaratives in the input. In addition, the children's prior use or non-use of auxiliary BE influenced subsequent use. The findings are discussed in the context of usage-based theories of language acquisition and the role of the language children hear in their developing linguistic representations.

Leukocyte kinetics in the human lung: role of exercise and catecholamines

1984 ◽  
Vol 57 (3) ◽  
pp. 711-719 ◽  
Author(s):  
A. L. Muir ◽  
M. Cruz ◽  
B. A. Martin ◽  
H. Thommasen ◽  
A. Belzberg ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Peripheral Blood ◽  
Human Lung ◽  
Work Load ◽  
Low Flow ◽  
Epinephrine Infusion ◽  
First Pass ◽  
Pass Through

In six normal supine subjects epinephrine infusion produced a greater leukocytosis with smaller changes in heart rate and blood pressure than did norepinephrine or isoproterenol. Upright exercise in those subjects produced a greater leukocytosis than supine exercise at the same work load. To determine the lung's participation in these events, indium-labeled neutrophils (PMN) were given to four of the subjects. We found that 20–25% were retained in the first pass through the lung when compared with technetium-labeled erythrocytes. The number of labeled PMN in the lung gradually decreased and the number in the spleen and the liver increased. Exercise and catecholamine infusion caused an acceleration in the release of labeled cells from the lung, an increase in both labeled and unlabeled cells in the peripheral blood, and an increase in the number of labeled cells in the liver and spleen. This suggests that increased perfusion of low-flow areas in the lung may contribute to the increased leukocytosis seen in association with both exercise and catecholamine infusion.

Corticosterone regulates behavioral effects of lipopolysaccharide and interleukin-1 beta in mice

1995 ◽  
Vol 269 (1) ◽  
pp. R154-R159 ◽  
Author(s):  
E. Goujon ◽  
P. Parnet ◽  
A. Aubert ◽  
G. Goodall ◽  
R. Dantzer
Keyword(s):  
Interleukin 1 ◽  
Behavioral Effects ◽  
Protective Effects ◽  
Interleukin 1 Beta ◽  
Social Exploration ◽  
Inhibitory Feedback ◽  
Adrenal Response ◽  
Acute Injection ◽  
Progesterone Antagonist

The modulatory role of endogenous corticoids in the behavioral effects of lipopolysaccharide (LPS) and recombinant human interleukin-1 beta (IL-1 beta) was studied in mice. Adrenalectomy enhanced the depression of social exploration induced by subcutaneous injection of 200 ng of IL-1 beta or 2 micrograms of LPS. This effect was mimicked by an acute injection of the progesterone antagonist RU-38486 (0.25-1 mg). Chronic replacement with a 15-mg corticosterone pellet abrogated the enhanced susceptibility of adrenalectomized animals to 200 ng of IL-1 beta but had only partial protective effects on their response to 400 ng of IL-1 beta and LPS. These results suggest that the pituitary-adrenal response to cytokines exerts an inhibitory feedback on the cell targets that mediate the behavioral effects of LPS and IL-1 beta.

Influence and Information Flow in Online Social Networks

2017 ◽  
Vol 9 (4) ◽  
pp. 1-17
Author(s):  
Afrand Agah ◽  
Mehran Asadi
Keyword(s):  
Social Networks ◽  
Online Social Networks ◽  
Large Data ◽  
Marketing Strategies ◽  
Large Data Sets ◽  
Divide And Conquer ◽  
Data Sets ◽  
Divide And Conquer Algorithm ◽  
Flow Of Information

This article introduces a new method to discover the role of influential people in online social networks and presents an algorithm that recognizes influential users to reach a target in the network, in order to provide a strategic advantage for organizations to direct the scope of their digital marketing strategies. Social links among friends play an important role in dictating their behavior in online social networks, these social links determine the flow of information in form of wall posts via shares, likes, re-tweets, mentions, etc., which determines the influence of a node. This article initially identities the correlated nodes in large data sets using customized divide-and-conquer algorithm and then measures the influence of each of these nodes using a linear function. Furthermore, the empirical results show that users who have the highest influence are those whose total number of friends are closer to the total number of friends of each node divided by the total number of nodes in the network.

Effect of longer periods of dark rearing on NMDA receptors in cat visual cortex

1994 ◽  
Vol 72 (3) ◽  
pp. 1220-1226 ◽  
Author(s):  
D. Czepita ◽  
S. N. Reid ◽  
N. W. Daw
Keyword(s):  
Visual Cortex ◽  
Nmda Receptor ◽  
Firing Rate ◽  
Spontaneous Activity ◽  
Visual Response ◽  
Visual Responses ◽  
Level Of Activity ◽  
Direction Of Movement ◽  
Excitatory Drive ◽  
Dark Rearing

1. Cats were reared in the dark to 3, 5, and 11 mo. We studied the N-methyl-D-aspartate (NMDA) receptor contribution to the visual response in the cortex, defined as the percentage reduction in visual response after application of 2-amino-5-phosphonovaleric acid (APV). We also studied the firing rate in response to the optimal visual stimulus and the spontaneous activity. We made comparisons of all these properties between light-reared and dark-reared animals. 2. The NMDA receptor contribution to the visual response in layers IV, V, and VI of dark-reared animals was substantially above that in light-reared animals at all ages tested. 3. The specificity of receptive field properties in dark-reared animals showed some degeneration between 6 wk and 3 mo of age. At > or = 3 mo, almost no cells were specific for orientation and direction of movement. 4. Firing rate was lower in dark-reared animals at all ages, suggesting a decrease in excitatory drive to the visual cortex. 5. Spontaneous activity was equal in dark- and light-reared animals, suggesting that the overall level of activity (including visual responses as well as spontaneous activity) in light-reared animals is higher than in dark-reared animals. This should tend to upregulate glutamate receptors in general in dark-reared animals.

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