Is it possible that playing a video game might help you improve your computational thinking abilities?

In this research, we looked at the cognitive and behavioral effects of playing Penguin Go, a video game that was created to help middle school kids improve their computational thinking (CT) abilities. Apart from the general efficacy of the game, we looked at the effects of a single game feature—constraints on the amount of blocks that may be used in a solution. Students' CT abilities increased dramatically after playing Penguin Go for fewer than two hours, according to the findings, but the extra limits had no meaningful effect on learning. Furthermore, although the game as a whole had no effect on students' views toward computer science, the limitations condition of the game had a detrimental effect on students' attitudes toward computer science. The outcomes of this study, as well as suggested possibilities for future research in the area of employing these sorts of games to build computational thinking abilities, are reviewed.

Psychosocial Effects of COVID-19 Measures on (Pre-)Dementia Patients During Second Lockdown

Background: The COVID-19 pandemic poses enormous social challenges, especially during lockdown. People with cognitive decline and their caregivers are particularly at risk of lockdown consequences. Objective: To investigate psychosocial effects in (pre-)dementia patients and caregivers during second lockdown and compare effects between first and second lockdown. Methods: We included n = 511 (pre-)dementia patients and n = 826 caregivers from the Amsterdam Dementia Cohort and via Alzheimer Nederland. All respondents completed a self-designed survey on psychosocial effects of COVID-19. We examined relations between experienced support and psychosocial and behavioral symptoms using logistic regression. In a subset of patients and caregivers we compared responses between first and second lockdown using generalized estimating equation. Results: The majority of patients (≥58%) and caregivers (≥60%) reported that family and friends, hobbies, and music helped them cope. Support from family and friends was strongly related to less negative feelings in patients (loneliness: OR = 0.3[0.1–0.6]) and caregivers (loneliness: OR = 0.2[0.1–0.3]; depression: OR = 0.4[0.2–0.5]; anxiety: OR = 0.4[0.3–0.6]; uncertainty: OR = 0.3[0.2–0.5]; fatigue: OR = 0.3[0.2–0.4]; stress: OR = 0.3[0.2–0.5]). In second lockdown, less psychosocial and behavioral symptoms were reported compared to first lockdown (patients; e.g., anxiety: 22% versus 13%, p = 0.007; apathy: 27% versus 8%, p < 0.001, caregivers; e.g., anxiety: 23% versus 16%, p = 0.033; patient’s behavioral problems: 50% versus 35%, p < 0.001). Patients experienced more support (e.g., family and friends: 52% versus 93%, p < 0.001; neighbors: 28% versus 66%, p < 0.001). Conclusion: During second lockdown, patients and caregivers adapted to challenges posed by lockdown, as psychosocial and behavioral effects decreased, while patients experienced more social support compared to first lockdown. Support from family and friends is a major protective factor for negative outcomes in patients and caregivers.

Assessment of the Behavioural Effects of Cartoon Viewing among Parents of Under-Five Children

Background of the Study: Cartoons are the most popular entertainment for the Children. Mostly children begin watching cartoons on television at the early age of six months, and by the age of two or three children become enthusiastic viewers. Objectives: The main objective of the study is to assess the behavioral effects of cartoon viewing among the parents of under-five children. Methodology: Descriptive study design was used to conduct the study in selected tertiary care hospital. As per the inclusion criteria 50 samples were selected by using non probability purposive sampling technique. Self structured questionnaire was used to collect data and the behavioral effects of cartoon viewing among the parents of under-five children. Results: The study findings revealed that, among 50 samples 32% of the Children had mild effects on behaviour, 66% had moderate effects on behaviour and 2% of the Children had sever effects on behaviour. The mean and standard deviation score of the study was 54.72+0.8571. There was a significant association between the behavioral effects of cartoon viewing and the age of the Children (χ2 = 7.6364 , P<0.05). Conclusion: The study concluded that, 32% of the children had mild effects on behaviour, 66% had moderate effects on behavior and 2% of the children had sever effects on behaviour. Keywords: Cartoons, behavioral effects, under five children, parents.

Interactions Between Opioids and Dextroamphetamine on Locomotor Activity: Influence of an Opioid's Relative Efficacy at the Mu Receptor

Opioids and stimulants are often used in combination for both recreational and non-recreational purposes. High-efficacy mu opioid agonists generally increase the behavioral effects of stimulants, whereas opioid receptor antagonists generally attenuate the behavioral effects of stimulants; however, less is known regarding the interactions between stimulants and opioids possessing low to intermediate efficacy at the mu receptor. The purpose of this study was to examine the role of an opioid's relative efficacy at the mu receptor in altering the behavioral effects of dextro(d-)amphetamine. To this end, opioids possessing a range of relative efficacy at the mu receptor were examined alone and in combination with cumulative doses of d-amphetamine on a test of open-field, locomotor activity in male rats. Levorphanol, buprenorphine, butorphanol, nalbuphine, (-)-pentazocine, (-)-metazocine, (-)-cyclazocine, (-)-NANM, and nalorphine increased the locomotor effects of d-amphetamine in either an additive or greater-than-additive manner according to an effect-additive model. Only the selective, high-efficacy kappa agonist, spiradoline, and the non-selective opioid receptor antagonist, naloxone, failed to increase the effects of d-amphetamine under the conditions examined. These data indicate that opioids possessing a large range of relative efficacy at the mu receptor, including those possessing very low relative efficacy, significantly increase the locomotor effects of d-amphetamine.

It's All About the Heart

This chapter aimed to provide responses, within the issue of cardiovascular health, to the effectiveness of the relation between the message's content (“what”) and form (“how”) and the triad of (cognitive-affective-behavioral) effects. The qualitative content analysis, concretely thematic and rhetorical types, was applied to a corpus of five ads from international campaigns (2015-2019) and three static Portuguese ads (2018-2019). One online survey of Portuguese university students (N = 55) was conducted. The findings show that the ads' issues vary from irreparable losses to the encouragement of healthy behaviors. The pathos tends to elicit various reactions (e.g., alarm, call to action, empathy, fear, guilt, hurt, worry). The logos are constructed of discursive devices (e.g., construction of a narrative, use of questions, selection of colors with connotative purposes, descriptions of concepts), evidence, and stylistic devices. Most of the respondents recognize the cognitive and affective influence, but not the behavioral effects.

Comparison of an Addictive Potential of μ-Opioid Receptor Agonists with G Protein Bias: Behavioral and Molecular Modeling Studies

Among different approaches to the search for novel—safer and less addictive—opioid analgesics, biased agonism has received the most attention in recent years. Some μ-opioid receptor agonists with G protein bias, including SR compounds, were proposed to induce diminished side effects. However, in many aspects, behavioral effects of those compounds, as well as the mechanisms underlying differences in their action, remain unexplored. Here, we aimed to evaluate the effects of SR-14968 and SR-17018, highly G protein-biased opioid agonists, on antinociception, motor activity and addiction-like behaviors in C57BL/6J mice. The obtained results showed that the compounds induce strong and dose-dependent antinociception. SR-14968 causes high, and SR-17018 much lower, locomotor activity. Both agonists develop reward-associated behavior and physical dependence. The compounds also cause antinociceptive tolerance, however, developing more slowly when compared to morphine. Interestingly, SR compounds, in particular SR-17018, slow down the development of antinociceptive tolerance to morphine and inhibit some symptoms of morphine withdrawal. Therefore, our results indicate that SR agonists possess rewarding and addictive properties, but can positively modulate some symptoms of morphine dependence. Next, we have compared behavioral effects of SR-compounds and PZM21 and searched for a relationship to the substantial differences in molecular interactions that these compounds form with the µ-opioid receptor.

Do Implicit Racial Biases Have Significant Discriminatory Effects?

This article investigates whether implicit racial biases have significant discriminatory effects. To this end, it evaluates meta-analyses of studies on measures of implicit bias and behavioral effects to which they are correlated. On balance, I maintain, the best interpretation of these meta-analyses and relevant surrounding research supports the conclusion that implicit racial biases are significantly correlated to racially biased behaviors, with effects that are consequential at both the individual and group levels. This conclusion is compatible with, but does not entail, the proposition that implicit racial biases in fact cause such effects. In consequence, I consider the contribution implicit bias research might make to our best accounts of racial discrimination and inequality on both a casual and non-causal construal. I argue it is plausible that research on implicit racial bias, on either construal, will play a substantive role in such accounts.

Adolescent THC Treatment Does Not Potentiate the Behavioral Effects in Adulthood of Maternal Immune Activation

Both in utero exposure to maternal immune activation and cannabis use during adolescence have been associated with increased risk for the development of schizophrenia; however, whether these exposures exert synergistic effects on brain function is not known. In the present study, mild maternal immune activation (MIA) was elicited in mice with prenatal exposure to polyinosinic-polycytidylic acid (poly(I:C)), and ∆9-tetrahydrocannabinol (THC) was provided throughout adolescence in cereal (3 mg/kg/day for 5 days). Neither THC nor MIA pretreatments altered activity in assays used to characterize hyperdopaminergic states in adulthood: amphetamine hyperlocomotion and prepulse inhibition of the acoustic startle reflex. Adolescent THC treatment elicited deficits in spatial memory and enhanced spatial reversal learning in adult female mice in the Morris water maze, while exposure to MIA elicited female-specific deficits in fear extinction learning in adulthood. There were no effects in these assays in adult males, nor were there interactions between THC and MIA in adult females. While doses of poly(I:C) and THC were sufficient to elicit behavioral effects, particularly relating to cognitive performance in females, there was no evidence that adolescent THC exposure synergized with the risk imposed by MIA to worsen behavioral outcomes in adult mice of either sex.