scholarly journals Arabidopsis Contains Nine Long-Chain Acyl-Coenzyme A Synthetase Genes That Participate in Fatty Acid and Glycerolipid Metabolism

2002 ◽  
Vol 129 (4) ◽  
pp. 1710-1722 ◽  
Author(s):  
Jay M. Shockey ◽  
Martin S. Fulda ◽  
John A. Browse
Keyword(s):  
Fatty Acid ◽  
Coenzyme A ◽  
Chain Acyl ◽  
Acyl Coenzyme A ◽  
Long Chain

scholarly journals Acyl Coenzyme A Thioesterase 7 Regulates Neuronal Fatty Acid Metabolism To Prevent Neurotoxicity

2013 ◽  
Vol 33 (9) ◽  
pp. 1869-1882 ◽  
Author(s):  
Jessica M. Ellis ◽  
G. William Wong ◽  
Michael J. Wolfgang
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Coenzyme A ◽  
Neurological Diseases ◽  
Conditional Knockout ◽  
Neurological Dysfunction ◽  
Chain Acyl ◽  
Acyl Coenzyme A ◽  
Long Chain

Numerous neurological diseases are associated with dysregulated lipid metabolism; however, the basic metabolic control of fatty acid metabolism in neurons remains enigmatic. Here we have shown that neurons have abundant expression and activity of the long-chain cytoplasmic acyl coenzyme A (acyl-CoA) thioesterase 7 (ACOT7) to regulate lipid retention and metabolism. Unbiased and targeted metabolomic analysis of fasted mice with a conditional knockout of ACOT7 in the nervous system, Acot7 N−/− , revealed increased fatty acid flux into multiple long-chain acyl-CoA-dependent pathways. The alterations in brain fatty acid metabolism were concomitant with a loss of lean mass, hypermetabolism, hepatic steatosis, dyslipidemia, and behavioral hyperexcitability in Acot7 N − / − mice. These failures in adaptive energy metabolism are common in neurodegenerative diseases. In agreement, Acot7 N − / − mice exhibit neurological dysfunction and neurodegeneration. These data show that ACOT7 counterregulates fatty acid metabolism in neurons and protects against neurotoxicity.

Roles of Long-chain Acyl Coenzyme A Synthetase in Absorption and Transport of Fatty Acid

2016 ◽  
Vol 31 (1) ◽  
pp. 62-64 ◽  
Author(s):  
Fan Gao ◽  
Xue-feng Yang ◽  
Nian Fu ◽  
Yang Hu ◽  
Yan Ouyang ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Coenzyme A ◽  
Chain Acyl ◽  
Acyl Coenzyme A ◽  
Long Chain

scholarly journals Mechanism of the control of (Na+ + K+)-ATPase by long-chain acyl coenzyme A

1989 ◽  
Vol 264 (5) ◽  
pp. 2605-2608
Author(s):  
W H Huang ◽  
Y Wang ◽  
A Askari
Keyword(s):  
Coenzyme A ◽  
Chain Acyl ◽  
Acyl Coenzyme A ◽  
Long Chain
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