scholarly journals Cognitive tasks modelization and description in VR environment for Alzheimer’s disease state identification

2020 ◽  
Author(s):  
MARONNAT Florian ◽  
SEGUIN Margaux ◽  
DJEMAL Khalifa
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease State ◽  
Cognitive Tasks ◽  
State Identification

Preclinical Cognitive Trajectories Differ for Alzheimer's Disease and Vascular Dementia

2012 ◽  
Vol 18 (2) ◽  
pp. 191-199 ◽  
Author(s):  
Erika J. Laukka ◽  
Stuart W.S. MacDonald ◽  
Laura Fratiglioni ◽  
Lars Bäckman
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Early Stage ◽  
Block Design ◽  
Word Recall ◽  
Cognitive Tasks ◽  
Control Group ◽  
Age Related ◽  
Preclinical Ad

AbstractWe investigated differences between Alzheimer's disease (AD) and vascular dementia (VaD) from the appearance of the first cognitive symptoms, focusing on both time of onset and rate of accelerated decline for different cognitive functions before dementia diagnosis. Data from a longitudinal population-based study were used, including 914 participants (mean age = 82.0 years, SD = 5.0) tested with a cognitive battery (word recall and recognition, Block Design, category fluency, clock reading) on up to four occasions spanning 10 years. We fit a series of linear mixed effects models with a change point to the cognitive data, contrasting each dementia group to a control group. Significant age-related decline was observed for all five cognitive tasks. Relative to time of diagnosis, the preclinical AD persons deviated from the normal aging curve earlier (up to 9 years) compared to the preclinical VaD persons (up to 6 years). However, once the preclinical VaD persons started to decline, they deteriorated at a faster rate than the preclinical AD persons. The results have important implications for identifying the two dementia disorders at an early stage and for selecting cognitive tasks to evaluate treatment effects for persons at risk of developing AD and VaD. (JINS, 2012, 18, 191–199)

Autonomic impairment in Alzheimer’s disease is revealed by complexity analysis of functional thermal imaging signals during cognitive tasks

2019 ◽  
Vol 40 (3) ◽  
pp. 034002 ◽  
Author(s):  
David Perpetuini ◽  
Daniela Cardone ◽  
Antonio Maria Chiarelli ◽  
Chiara Filippini ◽  
Pierpaolo Croce ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Thermal Imaging ◽  
Complexity Analysis ◽  
Cognitive Tasks

Alterations in Phase-Related Prefrontal Activation During Cognitive Tasks and Nicotinic α4β2 Receptor Availability in Alzheimer’s Disease

2016 ◽  
Vol 53 (3) ◽  
pp. 817-830 ◽  
Author(s):  
Yumi Oboshi ◽  
Mitsuru Kikuchi ◽  
Tatsuhiro Terada ◽  
Etsuji Yoshikawa ◽  
Tomoyasu Bunai ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Tasks

scholarly journals ROLE OF MICROBES IN THE DEVELOPMENT OF ALZHEIMER’S DISEASE: STATE OF THE ART

2017 ◽  
Vol 1 (suppl_1) ◽  
pp. 274-274
Author(s):  
A.E. Barron ◽  
R. Itzhaki ◽  
J. Miklossy
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
State Of The Art ◽  
Disease State

Predicting Progression from Cognitive Impairment to Alzheimer’s Disease with the Disease State Index

2015 ◽  
Vol 12 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Anette Hall ◽  
Jussi Mattila ◽  
Juha Koikkalainen ◽  
Jyrki Lotjonen ◽  
Robin Wolz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Disease State ◽  
State Index

Body-centred and Object-centred Motor Imagery in Alzheimer's Disease

2018 ◽  
Vol 15 (3) ◽  
pp. 247-258 ◽  
Author(s):  
Xavier Corveleyn ◽  
Blampain Justine ◽  
Laurent Ott ◽  
Isabelle Lavenu ◽  
Caroline Delayen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Response Time ◽  
Mental Rotation ◽  
Motor Imagery ◽  
Body Movement ◽  
Peripersonal Space ◽  
Judgment Task ◽  
Cognitive Tasks ◽  
Implicit Motor

Objective: Autonomy in patients with Alzheimer's disease (AD) in daily life depends on the preservation of neurocognitive and motor abilities, which decline over time. So far, very few studies have investigated motor representations and their contribution to perception and cognition in AD. Methods: In the present study, we compared the performance of AD patients to age-matched healthy participants in perceptual and cognitive tasks involving motor imagery. Experiment 1 tested explicit motor and visual imagery through an imagined movement task. Experiment 2 tested body-centred implicit motor imagery through a mental rotation of visual hand task. Finally, Experiment 3 tested object-centred implicit motor imagery through a reachability judgment task. Results: The results showed that, compared to age-matched controls, conscious imagination of a body movement or the movement of a visual stimulus was much longer in AD patients, with no specific difficulty in the motor condition (Experiment 1). Furthermore, response time in AD patients was strongly affected by the angle of rotation of the visual stimuli in the mental rotation of hand task (Experiment 2). Likewise, response time in AD patients increased substantially in the reachability judgment task, but predominantly for stimuli located at the boundary of peripersonal space (Experiment 3). Conclusion: As a whole, the data suggested a decline in AD of implicit, but not explicit, motor imagery capacities affecting processing time, but not performance accuracy, in motor-related perceptual and cognitive tasks.

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