scholarly journals Single Burst Depth-Resolving Raman Spectrometer Based on a SPAD Array with an On-Chip TDC to Analyse Heterogenous Liquid Samples

Author(s):  
Jere Kekkonen ◽  
Ilkka Nissinen
2015 ◽  
Vol 7 (19) ◽  
pp. 8472-8477 ◽  
Author(s):  
Jennifer Campbell ◽  
Nira R. Pollock ◽  
Andre Sharon ◽  
Alexis F. Sauer-Budge

We present a lab-on-a-chip and associated instrument for heterogeneous enzyme-linked immunosorbent assay (ELISA)-based detection of proteins from liquid samples.


1970 ◽  
Vol 110 (4) ◽  
pp. 61-66
Author(s):  
A. T. Giannitsis ◽  
T. Parve ◽  
M. Min

Lab-on-chip devices comprise a class of bioelectronic miniaturized devices that incorporate microfluidic and biosensing apparatuses on a single chip. They are dedicated for analyzing and processing biochemical liquid samples, which may consist of enzymes, proteins, nucleotides, or even cells and viruses. Furthermore, lab-on-chips may enhance synthesis of biochemical products. The importance of lab-on-chip devices lies on their potentiality of advancing the development of environmental monitoring sensors and also point-of-care analyzers in medicine. This article presents the usual microfabrication methods for manufacturing lab-on-chip devices, with emphasis on the integration of the biosensor, the biocompatibility of the sensing element of the biosensor, and the essential electronics. Three major types of biosensors are analyzed: optical, impedimetric and electrochemical ones. Ill. 7, bibl. 28 (in English; abstracts in English and Lithuanian).http://dx.doi.org/10.5755/j01.eee.110.4.288


Author(s):  
Manabu Tokeshi ◽  
Kazuteru Kanda ◽  
Akihide Hibara ◽  
Takehiko Kitamori

2020 ◽  
Vol 477 (14) ◽  
pp. 2679-2696
Author(s):  
Riddhi Trivedi ◽  
Kalyani Barve

The intestinal microbial flora has risen to be one of the important etiological factors in the development of diseases like colorectal cancer, obesity, diabetes, inflammatory bowel disease, anxiety and Parkinson's. The emergence of the association between bacterial flora and lungs led to the discovery of the gut–lung axis. Dysbiosis of several species of colonic bacteria such as Firmicutes and Bacteroidetes and transfer of these bacteria from gut to lungs via lymphatic and systemic circulation are associated with several respiratory diseases such as lung cancer, asthma, tuberculosis, cystic fibrosis, etc. Current therapies for dysbiosis include use of probiotics, prebiotics and synbiotics to restore the balance between various species of beneficial bacteria. Various approaches like nanotechnology and microencapsulation have been explored to increase the permeability and viability of probiotics in the body. The need of the day is comprehensive study of mechanisms behind dysbiosis, translocation of microbiota from gut to lung through various channels and new technology for evaluating treatment to correct this dysbiosis which in turn can be used to manage various respiratory diseases. Microfluidics and organ on chip model are emerging technologies that can satisfy these needs. This review gives an overview of colonic commensals in lung pathology and novel systems that help in alleviating symptoms of lung diseases. We have also hypothesized new models to help in understanding bacterial pathways involved in the gut–lung axis as well as act as a futuristic approach in finding treatment of respiratory diseases caused by dysbiosis.


1983 ◽  
Vol 44 (C6) ◽  
pp. C6-165-C6-170
Author(s):  
G. Rousset ◽  
J. P. Monchalin ◽  
L. Bertrand

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