Impact of μ-map Processing and Transmission Scan Count Statistics on Quantification of PET Pig Brain Scans - and Temporal Variation of Scatter Correction Induced by μ-map Mismatch

Author(s):  
Sune H. Keller ◽  
Bjorg Vigfsdottir ◽  
Jonas Villadsen ◽  
Louise Moller Jorgensen ◽  
Hanne D. Hansen ◽  
...  
2007 ◽  
Vol 46 (03) ◽  
pp. 101-106 ◽  
Author(s):  
J. Hashimoto ◽  
K. Ogawa ◽  
A. Kubo ◽  
A. Fukunaga ◽  
S. Onozuka ◽  
...  

SummaryThe aim of this study was to evaluate the effect of scatter and attenuation correction in region of interest (ROI) analysis of brain perfusion single-photon emission tomography (SPECT), and to assess the influence of selecting the reference area on the calculation of lesion-to-reference count ratios. Patients, methods: Data were collected from a brain phantom and ten patients with unilateral internal carotid artery stenosis. A simultaneous emission and transmission scan was performed after injecting 123I-iodoamphetamine. We reconstructed three SPECT images from common projection data: with scatter correction and nonuniform attenuation correction, with scatter correction and uniform attenuation correction, and with uniform attenuation correction applied to data without scatter correction. Regional count ratios were calculated by using four different reference areas (contralateral intact side, ipsilateral cerebellum, whole brain and hemisphere). Results: Scatter correction improved the accuracy of measuring the count ratios in the phantom experiment. It also yielded marked difference in the count ratio in the clinical study when using the cerebellum, whole brain or hemisphere as the reference. Difference between nonuniform and uniform attenuation correction was not significant in the phantom and clinical studies except when the cerebellar reference was used. Calculation of the lesion-to-normal count ratios referring the same site in the contralateral hemisphere was not dependent on the use of scatter correction or transmission scan-based attenuation correction. Conclusion: Scatter correction was indispensable for accurate measurement in most of the ROI analyses. Nonuniform attenuation correction is not necessary when using the reference area other than the cerebellum.


Nature ◽  
2003 ◽  
Author(s):  
Geoff Brumfiel
Keyword(s):  

2004 ◽  
Vol 43 (06) ◽  
pp. 185-189 ◽  
Author(s):  
J. T. Kuikka

Summary Aim: Serotonin transporter (SERT) imaging can be used to study the role of regional abnormalities of neurotransmitter release in various mental disorders and to study the mechanism of action of therapeutic drugs or drugs’ abuse. We examine the quantitative accuracy and reproducibility that can be achieved with high-resolution SPECT of serotonergic neurotransmission. Method: Binding potential (BP) of 123I labeled tracer specific for midbrain SERT was assessed in 20 healthy persons. The effects of scatter, attenuation, partial volume, mis-registration and statistical noise were estimated using phantom and human studies. Results: Without any correction, BP was underestimated by 73%. The partial volume error was the major component in this underestimation whereas the most critical error for the reproducibility was misplacement of region of interest (ROI). Conclusion: The proper ROI registration, the use of the multiple head gamma camera with transmission based scatter correction introduce more relevant results. However, due to the small dimensions of the midbrain SERT structures and poor spatial resolution of SPECT, the improvement without the partial volume correction is not great enough to restore the estimate of BP to that of the true one.


2013 ◽  
Vol 485 ◽  
pp. 91-103 ◽  
Author(s):  
A Perea-Blázquez ◽  
SK Davy ◽  
B Magana-Rodríguez ◽  
JJ Bell

1988 ◽  
Vol 117 (4_Suppl) ◽  
pp. S112-S113
Author(s):  
N. PARVIZI
Keyword(s):  

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