Surfactant-Induced Stratum Corneum Hydration In Vivo: Prediction of the Irritation Potential of Anionic Surfactants

1993 ◽  
Vol 101 (3) ◽  
pp. 310-315 ◽  
Author(s):  
Klaus-P Wilhelm ◽  
Anastasia B Cua ◽  
Helmut H Wolff ◽  
Howard I Maibach
Keyword(s):  
Stratum Corneum ◽  
Anionic Surfactants ◽  
Stratum Corneum Hydration

scholarly journals The Effect of in Vivo Occlusion on Human Stratum Corneum Hydration-Dehydration in Vitro

1973 ◽  
Vol 61 (6) ◽  
pp. 375-379 ◽  
Author(s):  
Robert L. Anderson ◽  
Jean M. Cassidy ◽  
John R. Hansen ◽  
Wilbur Yellin
Keyword(s):  
Stratum Corneum ◽  
Human Stratum Corneum ◽  
Stratum Corneum Hydration

In Vivo Cutaneous and Perceived Comfort Response to Fabric: Part VI: The Effect of Moist Fabrics on Stratum Corneum Hydration

1997 ◽  
Vol 67 (12) ◽  
pp. 926-931 ◽  
Author(s):  
Kathryn L. Hatch ◽  
Harriet H. Prato ◽  
S. Haig Zeronian ◽  
Howard I. Maibach
Keyword(s):  
Moisture Content ◽  
Stratum Corneum ◽  
Water Loss ◽  
Initial Moisture Content ◽  
Polyester Fabric ◽  
Evaporative Water Loss ◽  
Evaporative Water ◽  
Potential Health ◽  
Stratum Corneum Hydration

Materials placed over human skin may change the stratum corneum (sc) hydration level, an important phenomenon because increases in normal levels of sc hydration pose potential health problems. This study examines the relationship between fabric moisture content and level of sc hydration so that the role of fabric moisture on sc hydration may be better understood. Three fabric/moisture treatments are placed on the sc—3.5-denier polyester fabric with an initial moisture content of 35% and cotton fabrics with either 44% or 75% initial moisture content—then covered with an occlusive dome. sc evaporative water loss (ewl) is measured before treatment placement and after 30 and 60 minutes of contact. The amount of moisture in the fabric at time of removal is calculated two different ways, and three analyses of variance are done using the evaporative water loss and two fabric final moisture content data sets. The rate of ewl is significantly higher after 30 minutes of treatment contact with sc than after 60 minutes of contact. The amount of moisture in the fabrics is significantly less at time 60 than at time 30, implying that the sc is more hydrated at 30 minutes than at 60 minutes. However, the fabrics contain less moisture when removed at 60 minutes than at 30 minutes. As fabric moisture content decreases, sc hydration decreases. The question we are not able to answer is “Where does the moisture go that is initially in the fabric?’

Comparative study of five instruments measuring stratum corneum hydration (Corneometer CM 820 and CM 825, Skicon 200, Nova DPM 9003, DermaLab). Part II. In vivo

1999 ◽  
Vol 5 (3) ◽  
pp. 171-178 ◽  
Author(s):  
Joachim W. Fluhr ◽  
Max Gloor ◽  
Sabrina Lazzerini ◽  
Peter Kleesz ◽  
Romano Grieshaber ◽  
...  
Keyword(s):  
Comparative Study ◽  
Stratum Corneum ◽  
Stratum Corneum Hydration

Methodology to measure the transient effect of occlusion on skin penetration and stratum corneum hydration in vivo

1988 ◽  
Vol 119 (3) ◽  
pp. 307-312 ◽  
Author(s):  
K. S. RYATT ◽  
M. MOBAYEN ◽  
J. M. STEVENSON ◽  
H. I. MAIBACH ◽  
R. H. GUY
Keyword(s):  
Stratum Corneum ◽  
Skin Penetration ◽  
Transient Effect ◽  
Stratum Corneum Hydration

In Vivo Cutaneous Response to Fabric Part V: Effect of Fiber Type and Fabric Moisture Content on Stratum Corneum Hydration

1992 ◽  
Vol 62 (11) ◽  
pp. 638-647 ◽  
Author(s):  
Kathryn L. Hatch ◽  
Nancy L. Markee ◽  
Harriet H. Prato ◽  
S. Haig Zeronian ◽  
Howard I. Maibach ◽  
...  
Keyword(s):  
Moisture Content ◽  
Stratum Corneum ◽  
Cotton Fabric ◽  
Fiber Type ◽  
Normal Skin ◽  
Polyester Fabric ◽  
Evaporative Water ◽  
Potential Health ◽  
Stratum Corneum Hydration

Fabric placed over human skin may change the stratum corneum (SC) hydration level, an important phenomenon because increases in normal levels of SC hydration pose potential health problems. The skin becomes more susceptible to abrasive damage, increases in permeability, and is more prone to microbial growth. The purpose of this study was to determine the effect of fiber type and fabric moisture content on SC hydration. Using three similarly constructed knit fabrics, six fabric type/moisture content combinations were selected for the tests. Using an occluded plastic dome, fabric samples were placed on both “normal” and “hydrated” volar forearm skin of subjects for a specified time period, then removed. Two minutes after removal, evaporative water loss and skin temperature were measured. The design of the study was a randomized complete block with all possible treatment combinations applied to each subject. Data were analyzed using analyses of variance on the linear and quadratic coefficients of best fit lines and Bonferroni t tests. For “normal” skin, SC hydration generally increased as fabric moisture content increased. The SC was significantly drier after being in contact with cotton fabric at regain than at the two moisture content levels above regain, and also under polyester fabric. For hydrated skin, the hydration state was significantly lower under the cotton fabric at regain than at 38.6% moisture content and at saturation, but was not significantly different under the polyester fabric at regain and at saturation.

The use of FT-IR for the determination of stratum corneum hydration in vitro and in vivo

1991 ◽  
Vol 9 (10-12) ◽  
pp. 1089-1094 ◽  
Author(s):  
Peter A.D. Edwardson ◽  
Michael Walker ◽  
Ronald S. Gardner ◽  
Elizabeth Jacques
Keyword(s):  
Stratum Corneum ◽  
Stratum Corneum Hydration ◽  
Ft Ir

scholarly journals Opto-thermal technique for in-vivo stratum corneum hydration measurement

1994 ◽  
Vol 04 (C7) ◽  
pp. C7-465-C7-468 ◽  
Author(s):  
R. M.S. Bindra ◽  
R. E. Imhof ◽  
A. Mochan ◽  
G. M. Eccleston
Keyword(s):  
Stratum Corneum ◽  
Stratum Corneum Hydration ◽  
Thermal Technique

scholarly journals Liposome percutaneous penetration in vivo

2017 ◽  
Vol 1 ◽  
pp. 239784731772319 ◽  
Author(s):  
A Lymberopoulos ◽  
C Demopoulou ◽  
M Kyriazi ◽  
MS Katsarou ◽  
N Demertzis ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Rhodamine B ◽  
Transdermal Delivery ◽  
Penetration Enhancers ◽  
Percutaneous Penetration ◽  
Hairless Mice ◽  
Liposomal Form ◽  
Multilamellar Vesicles ◽  
Small Unilamellar Vesicles

Objectives: Liposomes are reported as penetration enhancers for dermal and transdermal delivery. However, little is known about their percutaneous penetration and as to at which level they deliver encapsulated drugs. The penetration of multilamellar vesicles (MLVs) and small unilamellar vesicles (SUVs), in comparison to one of their lipid components, was investigated. Methods: Using the fluorescent lipid, Lissamine Rhodamine B-PE (R), as a constituent, MLV and SUV liposomes were prepared, tested, and R, MLV, or SUV were applied in vivo on the back of hairless mice. Absorption of each was evaluated at the levels of stratum corneum, living skin, and blood by fluorometry. Results: Penetration of the lipid R in stratum corneum in the nonliposomal form exceeded that in the liposomal form and only R penetrates the living skin in a statistically significant manner. No statistical significant absorption into blood was observed with either form. Conclusions: Liposomes size did not play an important role in penetration to stratum corneum. The lipid constituent in the nonliposomal form penetrated at higher rates into stratum corneum and living skin. Even though these liposomes entered stratum corneum, they were not significantly absorbed into viable skin or blood.

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