Estimated trans-lamina cribrosa pressure difference versus intraocular pressure as biomarker for open-angle glaucoma. The Beijing Eye Study 2011

2014 ◽  
Vol 93 (1) ◽  
pp. e7-e13 ◽  
Author(s):  
Jost B. Jonas ◽  
Ning Li Wang ◽  
Ya Xing Wang ◽  
Qi Sheng You ◽  
Xiao Bin Xie ◽  
...  
Author(s):  
Avinash Ayyalasomayajula ◽  
Jonathan P. Vande Geest

There is a general consensus that elevation in intraocular pressure (IOP), due to a reduced outflow of aqueous humor, is a major factor leading to primary open-angle glaucoma (POAG). Studies indicated that the damage of the optic nervehead (ONH), due to the biomechanical environment in and around the lamina cribrosa (LC), could be an important event leading to POAG [Morgan]. Since experimentally testing tissues of such small dimensions is difficult, many researchers resorted to computationally model the biomechincal environment inside the eye [Avatar, Kobayashi, Sigal, Uchio, Xu, Tandon]. It also gives the flexibility to parametrically study and isolate the effects of individual tissues on the IOP and LC. Many of these studies involve stress analysis on a hypothetical geometry (for e.g. spherical or axisymmetric hemisphere) using a variety of constitutive models (for e.g. elastic, biphasic etc) to study the static, and dynamic response of the IOP [Tandon, Sigal].


PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e82284 ◽  
Author(s):  
Jost B. Jonas ◽  
Vinay Nangia ◽  
Ningli Wang ◽  
Karishma Bhate ◽  
Prabhat Nangia ◽  
...  

Author(s):  
E. N. Simakova ◽  
O. V. Stenkova

Introduction. Glaucoma is one of the most significant eye diseases. It is often diagnosed, not always amenable to therapy, and can lead to a complete loss of visual functions. In recent years, the method of osteopathic correction has become widespread as one of the effective methods of treatment and rehabilitation of patients with pathologies of various body systems. In the pathogenesis of glaucoma, it is customary to distinguish a dystrophic concept, which considers primary open-angle glaucoma as a result of dystrophic changes in the connective tissue, as well as in the endothelial lining of the trabeculae and Schlemm′s canal, especially destructive changes in mitochondria and the alteration of their functional activity. A vascular concept is also distinguished. According to this concept, the central link in the pathogenesis of glaucoma is circulatory disorder in the ciliary vessels, ocular artery, and major vessels of the head and neck, it can be assumed that osteopathic correction in the treatment of patients with open-angle glaucoma will be pathogenetically substantiated and will have a positive effect on intraocular pressure and trophicity of the optic nerve. The goal of research — to study the influence of in osteopathic correction on the nature of unoperated glaucoma (stage IIA) and to substantiate the possibility of using osteopathic correction in the complex treatment of patients with this pathology.Materials and methods. A prospective controlled randomized study was conducted at 52 city polyclinics, branch 3, Moscow, from January 2018 to January 2019. 40 patients (70 eyes) aged 50 to 75 years with primary open-angle glaucoma IIA stage were examined. At this stage of the disease, patients most often seek medical care and the issue of conservative management is primarily considered. All patients were divided into two groups of 20 people: the main group and the control group. The treatment in the main group included hypotensive drug therapy and osteopathic correction. Patients of the control group received only drug therapy. All patients underwent ophthalmic (visometry, tonometry, perimetry) and osteopathic examination twice: before the treatment and after 3 months.Results. For patients with primary open-angle IIA non-operated glaucoma, regional (most often regions of the head, neck, dura mater) and local (abdominal diaphragm, iliac bones, hip and knee joints) somatic dysfunctions were the most typical. In the main group a statistically significant decrease in the frequency and severity of dysfunctions at all levels was stated. Also, in patients receiving osteopathic correction, a significant decrease in the level of intraocular pressure and perimetric indices was noted. In patients of the control group, no reliable changes in these indicators were obtained.Conclusion. The results obtained indicate that osteopathic correction is clinically effective in the complex treatment of patients with primary open-angle II A glaucoma.


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