Elderly Patients at Risk for Coronary Heart Disease or Stroke: Selecting an Ideal Product for Lipid Lowering

Abstract BackgroundIt has been reported chemokine CC-motif ligand 17 (CCL17), an inflammatory mediator modulating T cells function to affect formation and stableness of atherosclerotic plaque and is associated with the severity of coronary heart disease (CHD). This research aims to further explore the relationship between serum CCL17 and the prognosis of patients at risk for CHD.MethodThis study retrospectively enrolled 495 patients receiving coronary angiogram at Peking Union Medical College Hospital from January 2012 to December 2013. Serum CCL17 was measured on admission and annual routine telephone follow-up was carried out till December 2020. The prognosis of patients was evaluated by the incidence of major adverse cardiovascular events (MACE). Cox survival analysis have been applied for univariate and multivariate models setting., Machine learning and data imbalance methods were also added to improve the model performance.ResultsCompared with patients with low serum CCL17 level, patients with medium and high serum CCL17 demonstrated elevated risk to develop MACE, with the hazard ratio (HR) being 4.53 [95% confidence interval (CI) 2.08-9.88] and 6.38 (95% CI 3.07-13.28) respectively. CCL17 served as an independent risk factor to predict the incidence of MACE and the addition of CCL17 to the baseline risk model significantly increase the predictive ability for MACE (Area under curve: baseline risk model 0.803±0.021 vs baseline risk model+CCL17 0.836±0.021, p for comparison<0.001).ConclusionsElevated CCL17 functions as an independent predictor for MACE in patients at risk for CHD and the potential mechanisms deserved more exploration in the future.

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Association between serum chemokine CC-motif ligand 17 and prognosis of patients at risk for coronary heart disease

10.21203/rs.3.rs-154494/v1 ◽

2021 ◽

Author(s):

Siqin Feng ◽

Lei Wang ◽

Yifei Wang ◽

Yiyang Wang ◽

Yuxiong Chen ◽

...

Keyword(s):

At Risk ◽

Coronary Heart Disease ◽

Heart Disease ◽

Risk Model ◽

Model Performance ◽

High Serum ◽

Baseline Risk ◽

Major Adverse Cardiovascular Events ◽

College Hospital ◽

Patients At Risk

Abstract Background It has been reported chemokine CC-motif ligand 17 (CCL17), an inflammatory mediator modulating T cells function to affect formation and stableness of atherosclerotic plaque and is associated with the severity of coronary heart disease (CHD). This research aims to further explore the relationship between serum CCL17 and the prognosis of patients at risk for CHD. Method This study retrospectively enrolled 495 patients receiving coronary angiogram at Peking Union Medical College Hospital from January 2012 to December 2013. Serum CCL17 was measured on admission and annual routine telephone follow-up was carried out till December 2020. The prognosis of patients was evaluated by the incidence of major adverse cardiovascular events (MACE). Cox survival analysis have been applied for univariate and multivariate models setting., Machine learning and data imbalance methods were also added to improve the model performance. Results Compared with patients with low serum CCL17 level, patients with medium and high serum CCL17 demonstrated elevated risk to develop MACE, with the hazard ratio (HR) being 4.53 [95% confidence interval (CI) 2.08-9.88] and 6.38 (95% CI 3.07-13.28) respectively. CCL17 served as an independent risk factor to predict the incidence of MACE and the addition of CCL17 to the baseline risk model significantly increase the predictive ability for MACE (Area under curve: baseline risk model 0.803±0.021 vs baseline risk model+CCL17 0.836±0.021, p for comparison<0.001). Conclusions Elevated CCL17 functions as an independent predictor for MACE in patients at risk for CHD and the potential mechanisms deserved more exploration in the future.

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