Gonadectomy Reverses The Sexually Diergic Patterns Of Circadian and Stress-Induced Hypothalamic-Pituitary-Adrenal Axis Activity In Male and Female Rats

2004 ◽  
Vol 16 (6) ◽  
pp. 516-524 ◽  
Author(s):  
J. V. Seale ◽  
S. A. Wood ◽  
H. C. Atkinson ◽  
E. Bate ◽  
S. L. Lightman ◽  
...  
Keyword(s):  
Hypothalamic Pituitary Adrenal Axis ◽  
Female Rats ◽  
Male And Female ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Male And Female Rats ◽  
Pituitary Adrenal Axis

DIVERGENT RESPONSES OF ARTERIOSCLEROTIC AND NON-ARTERIOSCLEROTIC RATS TO A CATABOLIC DOSE OF CORTISONE

1969 ◽  
Vol 61 (3) ◽  
pp. 509-524 ◽  
Author(s):  
Bernard C. Wexler ◽  
Jack Saroff
Keyword(s):  
Arterial Disease ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Female Rats ◽  
Ground Substance ◽  
Disuse Atrophy ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Male And Female Rats ◽  
Renal Changes ◽  
Pituitary Adrenal Axis

ABSTRACT Male and female rats bred repeatedly develop arteriosclerosis spontaneously. Current information indicates that stimulation of the hypothalamic-pituitary-adrenal axis in association with the active, repeated breeding may be responsible for the increased adrenocortical steroid production which would account for the abnormal lipid, carbohydrate and protein metabolism and arteriosclerosis observed in these animals. Arteriosclerotic breeder rats and non-arteriosclerotic virgin rats were given chronic injections of cortisone. The arteriosclerotic animals showed the most significant catabolic effects due to overdose with steroid, i. e., loss in body weight, disuse atrophy of the adrenal gland, reduced serum corticosterone levels, thymus gland involution, myocardial and renal changes. The excess glucocorticoid caused an acceleration of the usual pattern of development of the arterial disease and increased severity of the pre-existing arteriosclerosis. The excess endogenous steroid did not induce arterial damage in previously non-arteriosclerotic animals. It is believed that the increased activity of the hypothalamic-pituitary-adrenal axis in repeatedly bred rats conditions the arterial wall towards derangement of connective tissue ground substance and elements and the development of arteriosclerosis, i. e., a hormonal basis for the pathogenesis of this model of cardiovascular disease.

Hypothalamic-pituitary-adrenal axis responsivity to an acute novel stress in female rats subjected to the chronic mild stress paradigm

2019 ◽  
Vol 1723 ◽  
pp. 146402
Author(s):  
Guillermo A. Ariza Traslaviña ◽  
Fernanda Pedrosa Torres ◽  
Procópio Cleber Gama de Barcelos Filho ◽  
Fabiana Lucio-Oliveira ◽  
Celso Rodrigues Franci
Keyword(s):  
Chronic Mild Stress ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Female Rats ◽  
Mild Stress ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis
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