Effect of Acetyl Salicylic Acid and Cetraxate on Human Gastric Mucosal Blood Flow: Clinical Application of Laser Doppler Measurement

1995 ◽  
Vol 7 (4) ◽  
pp. 392-396
Author(s):  
Hiroko USUI
Keyword(s):  
Blood Flow ◽  
Salicylic Acid ◽  
Clinical Application ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Laser Doppler ◽  
Acetyl Salicylic Acid ◽  
Doppler Measurement

A New Laser Doppler Interface for the Continuous Measurement of the Rat Gastric Mucosal Blood Flow

1986 ◽  
Vol 18 (1) ◽  
pp. 41-49 ◽  
Author(s):  
M. Durlik ◽  
R. Benichoux ◽  
J.M. Lopez-Gollonet ◽  
G. Karcher
Keyword(s):  
Blood Flow ◽  
Continuous Measurement ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Laser Doppler

Gastric mucosal blood flow measured by laser-Doppler velocimetry

1985 ◽  
Vol 249 (4) ◽  
pp. G539-G545 ◽  
Author(s):  
J. W. Kiel ◽  
G. L. Riedel ◽  
G. R. DiResta ◽  
A. P. Shepherd
Keyword(s):  
Blood Flow ◽  
Laser Doppler Velocimetry ◽  
Reactive Hyperemia ◽  
Arterial Occlusion ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Laser Doppler ◽  
Doppler Velocimetry ◽  
Blood Flows ◽  
Ldv Measurement

To determine the feasibility of measuring gastric mucosal blood flow by laser-Doppler velocimetry (LDV), we utilized two LDV flowmeters to monitor blood flow in mucosa and serosa of chambered canine stomach. In isolated, nonautoregulating gastric segments vasodilated with isoproterenol, LDV mucosal and muscularis blood flows were both linearly related to total electromagnetic blood flow during step increases in perfusion pressure. To assess the depth of the LDV measurement, we recorded reactive hyperemia following arterial occlusion. Reactive hyperemia was frequently registered in the mucosa but rarely in muscularis. Placing a layer of nonperfused mucosa-submucosa between the probe and the perfused mucosa abolished the resting LDV mucosal flow signal and attenuated the recording of peak hyperemia by 85%. Furthermore, intra-arterial infusions of both adenosine and isoproterenol frequently increased LDV mucosal flow and decreased LDV muscularis flow, although total flow was consistently increased. These findings indicate that our LDV instruments yield linear, superficial measurements of gastric blood flow in either mucosa or muscularis. Although calibration in absolute units remains to be achieved, our results demonstrate that LDV is a practical means of studying the gastric mucosal microcirculation.

Laser-Doppler measurement of tracheal mucosal blood flow: comparison with tracheal arterial flow

1991 ◽  
Vol 70 (1) ◽  
pp. 274-281 ◽  
Author(s):  
D. R. Corfield ◽  
M. E. Deffebach ◽  
I. Erjefalt ◽  
R. O. Salonen ◽  
S. E. Webber ◽  
...  
Keyword(s):  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Laser Doppler ◽  
Doppler Measurement ◽  
Tracheal Mucosa ◽  
Doppler Flowmetry ◽  
Arterial Perfusion ◽  
Arterial Inflow ◽  
Electromagnetic Flow Probe ◽  
Tracheal Mucosal Blood Flow

Blood flow in the tracheal mucosa (Qm) has been measured by laser-Doppler flowmetry in anesthetized sheep and dogs. The values have been compared with tracheal arterial inflow (Qtr) by use of an electromagnetic flow probe and with tracheal arterial perfusion pressure (Ptr) produced by mechanical perfusion. Changes in blood flow were caused by injections of methacholine, phenylephrine, and histamine into the perfusion circuit. These interventions produced a range of measurements for each animal. Correlations of Qm against Qtr were significant in two of five animals (R = 0.03–0.93); correlations of Qm against Ptr were significant in two of four animals (R = 0.56–0.96). Percent changes in Qtr were generally much larger than those of Qm, and there was considerable variability between Qm and either Qtr or Ptr. Qm reflected the same vascular changes as Ptr or Qtr in 28 interventions and showed an opposing change in 4 cases. In 11 interventions, changes measured by Ptr or Qtr were not reflected by any changes in Qm. Thus qualitative changes in tracheal perfusion measured with these methods were usually the same; quantitatively the three methods showed great differences. These differences may reflect different regulatory mechanisms in various components of the tracheal vasculature or different technical aspects of the methods used.

Gastric mucosal blood flow after smoking in healthy human beings assessed by laser Doppler flowmetry

1993 ◽  
Vol 39 (3) ◽  
pp. 400-403 ◽  
Author(s):  
Tadashi Iwao ◽  
Atsushi Toyonaga ◽  
Motoki Ikegami ◽  
Kazuhiko Oho ◽  
Michihiro Sumino ◽  
...  
Keyword(s):  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Laser Doppler ◽  
Human Beings ◽  
Healthy Human ◽  
Doppler Flowmetry

Observer Agreement and Variability in Measuring Gastric Mucosal Blood Flow by Laser Doppler Flowmetry in Humans

Endoscopy ◽  
1993 ◽  
Vol 25 (04) ◽  
pp. 274-277 ◽  
Author(s):  
T. Iwao ◽  
A. Toyonaga ◽  
M. Ikegami ◽  
K. Oho ◽  
M. Sumino ◽  
...  
Keyword(s):  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Laser Doppler ◽  
Observer Agreement ◽  
Doppler Flowmetry

Limitations of laser-Doppler velocimetry and reflectance spectrophotometry in estimating gastric mucosal blood flow

1992 ◽  
Vol 263 (5) ◽  
pp. G810-G815 ◽  
Author(s):  
M. Casadevall ◽  
J. Panes ◽  
J. M. Pique ◽  
J. Bosch ◽  
J. Teres ◽  
...  
Keyword(s):  
Blood Flow ◽  
Gastric Mucosa ◽  
Reference Method ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Hydrogen Gas ◽  
Laser Doppler ◽  
Reflectance Spectrophotometry ◽  
Doppler Flowmetry ◽  
Normovolemic Anemia

This study investigated the accuracy of laser-Doppler flowmetry (LDV) and reflectance spectrophotometry (RS) measurements as an index of blood flow in the gastric mucosa of the rat, in experimental conditions such as pharmacologically induced vasoconstriction, hypoxia, hyperoxia, and acute normovolemic anemia. Hydrogen gas clearance was used as a reference method. After vasopressin infusion, LDV signal and indexes of hemoglobin (IHb) and oxygen (ISO2) content in the gastric mucosa estimated by RS significantly decreased in parallel with the reduction of gastric mucosal blood flow (GMBF). Neither hypoxia (5% O2 administration) nor hyperoxia (100% O2) affected GMBF or LDV signal. However, both IHb and ISO2 significantly decreased or increased after hypoxia or hyperoxia, respectively. Acute normovolemic anemia induced a significant increase in GMBF, while LDV signal and ISO2 remained unchanged. IHb significantly decreased in linear relationship with the decrements in the hematocrit. It is concluded that 1) in pharmacologically induced GMBF changes, LDV and RS correlate with GMBF; 2) when changes in hemoglobin saturation are induced, LDV but not RS reflects GMBF; and 3) in acute normovolemic anemia, neither LDV nor RS reflects changes in GMBF.

scholarly journals Laser Doppler measurement of rectal mucosal blood flow

Gut ◽  
1999 ◽  
Vol 45 (1) ◽  
pp. 64-69 ◽  
Author(s):  
A V Emmanuel ◽  
M A Kamm
Keyword(s):  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Laser Doppler ◽  
Doppler Measurement
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