scholarly journals Peripheral and central sites of action for the non-selective cannabinoid agonist WIN 55,212-2 in a rat model of post-operative pain

2009 ◽  
Vol 157 (4) ◽  
pp. 645-655 ◽  
Author(s):  
CZ Zhu ◽  
JP Mikusa ◽  
Y Fan ◽  
PR Hollingsworth ◽  
M Pai ◽  
...  
Keyword(s):  
Rat Model ◽  
Post Operative Pain ◽  
Sites Of Action ◽  
Cannabinoid Agonist

Differential Behavioral Effects of Peripheral and Systemic Morphine and Naloxone in a Rat Model of Repeated Acute Inflammation

2001 ◽  
Vol 94 (5) ◽  
pp. 870-875 ◽  
Author(s):  
Serge Perrot ◽  
Gisèle Guilbaud ◽  
Valérie Kayser
Keyword(s):  
Rat Model ◽  
Behavioral Effects ◽  
Endogenous Opioid System ◽  
Endogenous Opioid ◽  
Peripheral Tissues ◽  
Carrageenan Injection ◽  
Antinociceptive Effects ◽  
Intravenous Morphine ◽  
System Activation ◽  
Sites Of Action

Background It has been reported that opioid antinociceptive effects are enhanced in animal models of inflammation, but it remains unclear whether this sensitization to morphine is related to predominant central or peripheral increased effects. Methods The authors compared the behavioral effects of intraplantar and intravenous morphine and naloxone in a rat model of repeated acute carrageenan-induced inflammation in which enhanced responses to noxious stimuli result from sensitization in peripheral tissues or central sensitization. The antinociceptive effects of intraplantar morphine (50, 75, 100, 150, and 200 microg), intravenous morphine (0.3, 0.6, and 1 mg/kg), and the pronociceptive effects of intraplantar naloxone methiodide (150 microg) and intravenous naloxone (1 mg/kg) against noxious pressure (vocalization thresholds to paw pressure) in rats were assessed 3 h after one or two carrageenan plantar injections performed 7 days apart. Results After the first carrageenan injection, intraplantar and intravenous morphine produced significant increase of vocalization thresholds to paw pressure in inflamed but not in noninflamed paws. After the second carrageenan injection, the antinociceptive effects of intraplantar morphine were significantly reduced compared with those obtained after the first carrageenan injection, whereas effects of intravenous morphine were significantly enhanced and present in both hind paws. Intravenous naloxone demonstrated similar pronociceptive patterns after the first and second carrageenan injection. Intraplantar naloxone methiodide produced pronociceptive effects in inflamed hind paw that were significantly enhanced after the second carrageenan injection. Conclusions When inflammation is enhanced by recurrent stimulations, the antinociceptive effects of systemic morphine are enhanced. This increase is more likely related to central than peripheral sites of action, beyond endogenous opioid system activation.

Preoperative housing in an enriched environment significantly reduces the duration of post-operative pain in a rat model of knee inflammation

2010 ◽  
Vol 469 (2) ◽  
pp. 219-223 ◽  
Author(s):  
Anne F. Gabriel ◽  
Marco A.E. Marcus ◽  
Wiel M.M. Honig ◽  
Elbert A.J. Joosten
Keyword(s):  
Rat Model ◽  
Enriched Environment ◽  
Post Operative Pain

scholarly journals Cannabinoid agonist WIN 55,212‐2 improves memory consolidation in a rat model of basal forebrain cholinergic lesion

2021 ◽  
Vol 17 (S9) ◽  
Author(s):  
Iker Bengoetxea de Tena ◽  
Jonatan Martínez‐Gardeazabal ◽  
Marta Moreno‐Rodríguez ◽  
Gorka Pereira‐Castelo ◽  
Iván Manuel ◽  
...  
Keyword(s):  
Rat Model ◽  
Memory Consolidation ◽  
Basal Forebrain ◽  
Cannabinoid Agonist

Antiallodynic Effect of Intrathecal Gabapentin and Its Interaction with Clonidine in a Rat Model of Postoperative Pain

2000 ◽  
Vol 92 (4) ◽  
pp. 1126-1131 ◽  
Author(s):  
Jen-Kun Cheng ◽  
Hui-Lin Pan ◽  
James C. Eisenach
Keyword(s):  
Amino Acid ◽  
Postoperative Pain ◽  
Rat Model ◽  
Mechanical Allodynia ◽  
Intrathecal Injection ◽  
Amino Acid Transporter ◽  
Amino Acid Transporters ◽  
Sprague Dawley ◽  
Acid Transporter ◽  
Sites Of Action

Background Systemic administration of gabapentin was shown previously to attenuate mechanical allodynia in a rat model of postoperative pain. Because intrathecal administration of gabapentin is effective in other hypersensitivity states, the authors tested its effect in the postoperative model, its interaction with another antiallodynic agent (clonidine), and a possible mechanism of gabapentin action (entry into sites of action via an L-amino acid transporter). Methods Male Sprague-Dawley rats were anesthetized with halothane, and an incision of the plantaris muscle of right hind paw induced punctate mechanical allodynia. Withdrawal threshold to von Frey filament application near the incision site was determined before and 2 h after surgery. Then, an intrathecal injection was performed and thresholds were determined every 30 min for 3 h thereafter. Results Paw incision induced a mechanical hypersensitivity (mechanical threshold > 25 g before incision and < 5 g after). Intrathecal gabapentin dose-dependently (10-100 microg) reduced mechanical allodynia. Intrathecal injection of an inhibitor of L-amino acid transporters or a competitor for this transporter, L-leucine, did not reverse the intrathecal effect of gabapentin. The ED50 of intrathecal gabapentin, clonidine, and their combination were 51, 31, and 9 microg, respectively, and isobolographic analysis showed synergy between gabapentin and clonidine. Conclusions Intrathecal gabapentin is effective against tactile allodynia that occurs after paw incision, and interacts synergistically with clonidine. Unlike results in vitro, gabapentin does not obligatorily need to enter cells via the L-amino acid transporter mechanism to achieve its effects in vivo.

The activation of spinal astrocytes contributes to preoperative anxiety-induced persistent post-operative pain in a rat model of incisional pain

2014 ◽  
Vol 19 (5) ◽  
pp. 733-740 ◽  
Author(s):  
Y. Liu ◽  
B. Hou ◽  
W. Zhang ◽  
Y.-E. Sun ◽  
L. Li ◽  
...  
Keyword(s):  
Rat Model ◽  
Preoperative Anxiety ◽  
Post Operative Pain ◽  
Incisional Pain

In vivo evaluation of post-operative pain reduction on rat model after implantation of intraperitoneal PET meshes functionalised with cyclodextrins and loaded with ropivacaine

Biomaterials ◽  
2019 ◽  
Vol 192 ◽  
pp. 260-270 ◽  
Author(s):  
Feng Chai ◽  
Mickael Maton ◽  
Stephanie Degoutin ◽  
Guillaume Vermet ◽  
Nicolas Simon ◽  
...  
Keyword(s):  
Rat Model ◽  
Pain Reduction ◽  
In Vivo Evaluation ◽  
Post Operative Pain

A742 BRADYKININ B2 ANTAGONIST HOE-140 DOES NOT REDUCE HYPERALGESIA IN A RAT MODEL FOR POST-OPERATIVE PAIN

1997 ◽  
Vol 87 (Supplement) ◽  
pp. 742A
Author(s):  
&NA; Leonard ◽  
T.J. Brennan ◽  
D.J. Kramer
Keyword(s):  
Rat Model ◽  
Post Operative Pain ◽  
Hoe 140
Sign in / Sign up

Export Citation Format

Share Document